EMAL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMAL1_HUMAN
• UniProt AC: O00423
• Protein Name: Echinoderm microtubule-associated protein-like 1
• Gene Name: EML1
• Organism: Homo sapiens (Human).
• Sequence Length: 815
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Detected in cytoplasmic punctae. Co-localizes with microtubules (PubMed:24859200). Enriched in perinuclear regions during interphase and in the region of spindle microtubules durin
• Protein Description: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se..
• Protein Sequence: MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	KARPLMQTLPLRTTV CCCCCHHCCCCEEEE	19.17	23312004
100	Phosphorylation	LRTTVNNGTVLPKKP CEEEEECCEECCCCC	16.40	32142685
108	Phosphorylation	TVLPKKPTGSLPSPS EECCCCCCCCCCCCC	48.56	23403867
110	Phosphorylation	LPKKPTGSLPSPSGV CCCCCCCCCCCCCCC	39.32	23927012
113	Phosphorylation	KPTGSLPSPSGVRKE CCCCCCCCCCCCCCC	36.67	26055452
113 (in isoform 3)	Phosphorylation	-	36.67	25849741
115	Phosphorylation	TGSLPSPSGVRKETA CCCCCCCCCCCCCCC	55.01	30266825
127	Phosphorylation	ETAVPATKSNIKRTS CCCCCCCCCCCCCCC	43.54	32645325
132 (in isoform 3)	Phosphorylation	-	35.72	22210691
133	Phosphorylation	TKSNIKRTSSSERVS CCCCCCCCCCCCCCC	28.14	20363803
134 (in isoform 3)	Phosphorylation	-	35.58	22210691
134	Phosphorylation	KSNIKRTSSSERVSP CCCCCCCCCCCCCCC	35.58	26699800
135	Phosphorylation	SNIKRTSSSERVSPG CCCCCCCCCCCCCCC	35.29	20363803
136	Phosphorylation	NIKRTSSSERVSPGG CCCCCCCCCCCCCCC	29.23	26699800
140	Phosphorylation	TSSSERVSPGGRRES CCCCCCCCCCCCCCC	24.85	20363803
144 (in isoform 3)	Phosphorylation	-	45.14	22210691
145 (in isoform 3)	Phosphorylation	-	55.78	22210691
147	Phosphorylation	SPGGRRESNGDSRGN CCCCCCCCCCCCCCC	44.28	30242111
151	Phosphorylation	RRESNGDSRGNRNRT CCCCCCCCCCCCCCC	43.41	26699800
154 (in isoform 3)	Phosphorylation	-	36.62	25849741
158	Phosphorylation	SRGNRNRTGSTSSSS CCCCCCCCCCCCCCC	38.75	26699800
159	Phosphorylation	RGNRNRTGSTSSSSS CCCCCCCCCCCCCCC	26.20	32645325
159 (in isoform 3)	Phosphorylation	-	26.20	25849741
160	Phosphorylation	GNRNRTGSTSSSSSG CCCCCCCCCCCCCCC	25.22	26657352
161	Phosphorylation	NRNRTGSTSSSSSGK CCCCCCCCCCCCCCC	33.69	26699800
162	Phosphorylation	RNRTGSTSSSSSGKK CCCCCCCCCCCCCCC	29.89	26699800
163	Phosphorylation	NRTGSTSSSSSGKKN CCCCCCCCCCCCCCC	34.04	26699800
171	Phosphorylation	SSSGKKNSESKPKEP CCCCCCCCCCCCCCC	52.72	29214152
173	Phosphorylation	SGKKNSESKPKEPVF CCCCCCCCCCCCCCE	54.82	23186163
181	Phosphorylation	KPKEPVFSAEEGYVK CCCCCCEECCCCEEE	34.70	23186163
186	Phosphorylation	VFSAEEGYVKMFLRG CEECCCCEEEEEECC	10.52	19060867
202	Acetylation	PVTMYMPKDQVDSYS EEEEECCHHHCCCCE	44.24	10534121
222	Ubiquitination	ELPTKRLKLEWVYGY ECCCCCEEEEEEEEE	48.68	-
396	Phosphorylation	TCGKSHLYFWTLEGS EECCCEEEEEEEECC	7.52	-
448	Phosphorylation	ILVWGKGTNRISYAV EEEECCCCCCEEEEE	25.47	-
452	Phosphorylation	GKGTNRISYAVQGAH CCCCCCEEEEEECCH	12.10	-
453	Phosphorylation	KGTNRISYAVQGAHE CCCCCEEEEEECCHH	14.39	-
473	Phosphorylation	LCMLRDGTLVSGGGK EEEEECCEEECCCCC	28.42	-
476	Phosphorylation	LRDGTLVSGGGKDRK EECCEEECCCCCCCE	34.53	-
486	Phosphorylation	GKDRKLISWSGNYQK CCCCEEEECCCCHHH	26.14	29083192
488	Phosphorylation	DRKLISWSGNYQKLR CCEEEECCCCHHHHC	15.46	29083192
491	Phosphorylation	LISWSGNYQKLRKTE EEECCCCHHHHCCCC	15.56	29083192
532	Phosphorylation	FVLQGTLSGDFTPIT EEEECEECCCCEECC	35.83	22210691
536	Phosphorylation	GTLSGDFTPITQGHT CEECCCCEECCCCCC	20.65	22210691
755	Phosphorylation	AHEKKLLSTGDDFGK HHHHHEECCCCCCCC	40.56	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMAL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMAL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMAL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I20L2_HUMAN	ISG20L2	physical	16189514
I20L2_HUMAN	ISG20L2	physical	19060904
TBA1B_HUMAN	TUBA1B	physical	24706829
TBB3_HUMAN	TUBB3	physical	24706829
EMAL1_HUMAN	EML1	physical	25740311
TBA1A_HUMAN	TUBA1A	physical	25740311
TBB3_HUMAN	TUBB3	physical	25740311
FBX28_HUMAN	FBXO28	physical	28514442
TBB2A_HUMAN	TUBB2A	physical	28514442
EMAL4_HUMAN	EML4	physical	28514442
TBB2B_HUMAN	TUBB2B	physical	28514442
TBB5_HUMAN	TUBB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.