| UniProt ID | RB40C_HUMAN | |
|---|---|---|
| UniProt AC | Q96S21 | |
| Protein Name | Ras-related protein Rab-40C | |
| Gene Name | RAB40C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 281 | |
| Subcellular Localization |
Cell membrane Lipid-anchor Cytoplasmic side . |
|
| Protein Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.. | |
| Protein Sequence | MGSQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGGGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSQGSPVKS -----CCCCCCCCCC | 30.03 | 29255136 | |
| 6 | Phosphorylation | --MGSQGSPVKSYDY --CCCCCCCCCCHHH | 20.91 | 29255136 | |
| 10 | Phosphorylation | SQGSPVKSYDYLLKF CCCCCCCCHHHHHHH | 24.38 | 26270265 | |
| 133 | Ubiquitination | NRLHLAFKRQVPTEQ CCCHHHHHCCCCHHH | 35.99 | 21890473 | |
| 192 | Ubiquitination | RPNRVFSLQDLCCRA CCCCEEEHHHHHHHH | 2.89 | 33845483 | |
| 211 | Ubiquitination | TPVHLIDKLPLPVTI CCHHHHCCCCCCEEH | 45.04 | 33845483 | |
| 237 | Phosphorylation | GMNAVMMHGRSYSLA CCCEEEECCCEEECC | 15.49 | 33259812 | |
| 240 | Phosphorylation | AVMMHGRSYSLASGA EEEECCCEEECCCCC | 24.54 | 28450419 | |
| 241 | Phosphorylation | VMMHGRSYSLASGAG EEECCCEEECCCCCC | 13.32 | 28450419 | |
| 242 | Phosphorylation | MMHGRSYSLASGAGG EECCCEEECCCCCCC | 20.78 | 25849741 | |
| 245 | Phosphorylation | GRSYSLASGAGGGGS CCEEECCCCCCCCCC | 34.17 | 23927012 | |
| 252 | Phosphorylation | SGAGGGGSKGNSLKR CCCCCCCCCCCCCCC | 40.44 | 28450419 | |
| 256 | Phosphorylation | GGGSKGNSLKRSKSI CCCCCCCCCCCCCCC | 43.89 | 33259812 | |
| 260 | Phosphorylation | KGNSLKRSKSIRPPQ CCCCCCCCCCCCCCC | 29.21 | 23312004 | |
| 262 | Phosphorylation | NSLKRSKSIRPPQSP CCCCCCCCCCCCCCC | 25.69 | 28450419 | |
| 268 | Phosphorylation | KSIRPPQSPPQNCSR CCCCCCCCCCCCCCC | 44.30 | 25849741 | |
| 273 | S-palmitoylation | PQSPPQNCSRSNCKI CCCCCCCCCCCCCCC | 2.77 | - | |
| 274 | Phosphorylation | QSPPQNCSRSNCKIS CCCCCCCCCCCCCCC | 46.42 | 28102081 | |
| 278 | Geranylgeranylation | QNCSRSNCKIS---- CCCCCCCCCCC---- | 4.34 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RB40C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RB40C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RB40C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CUL5_HUMAN | CUL5 | physical | 15601820 | |
| RBX2_HUMAN | RNF7 | physical | 15601820 | |
| ELOB_HUMAN | TCEB2 | physical | 15601820 | |
| ELOC_HUMAN | TCEB1 | physical | 15601820 | |
| BICL2_MOUSE | Ccdc64b | physical | 20360680 | |
| RB40C_HUMAN | RAB40C | physical | 23638186 | |
| PLIN3_MOUSE | Plin3 | physical | 23638186 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
