DCNL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCNL2_HUMAN
• UniProt AC: Q6PH85
• Protein Name: DCN1-like protein 2
• Gene Name: DCUN1D2
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Protein Description: Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity..
• Protein Sequence: MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDDFVEYARPVVTGGKRSLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MHKLKSSQKDKVR --CCCCCCCHHHHHH	48.73	27174698
7	Phosphorylation	-MHKLKSSQKDKVRQ -CCCCCCCHHHHHHH	39.40	27174698
18	S-nitrosylation	KVRQFMACTQAGERT HHHHHHHHCCCCCCE	1.62	24105792
19	Phosphorylation	VRQFMACTQAGERTA HHHHHHHCCCCCCEE	16.35	23663014
25	Phosphorylation	CTQAGERTAIYCLTQ HCCCCCCEEEEEEEC	17.07	23663014
28	Phosphorylation	AGERTAIYCLTQNEW CCCCEEEEEEECCEE	4.48	23663014
31	Phosphorylation	RTAIYCLTQNEWRLD CEEEEEEECCEEECC	26.28	23663014
41	Phosphorylation	EWRLDEATDSFFQNP EEECCCCCHHHHCCH	30.08	26471730
43	Phosphorylation	RLDEATDSFFQNPDS ECCCCCHHHHCCHHH	24.49	26471730
50	Phosphorylation	SFFQNPDSLHRESMR HHHCCHHHHCHHHHH	27.60	26471730
55	Phosphorylation	PDSLHRESMRNAVDK HHHHCHHHHHHHHCH	24.01	-
69	Phosphorylation	KKKLERLYGRYKDPQ HHHHHHHHCCCCCCC	13.04	20562096
138	Ubiquitination	CDSMEKLKALLPRLE CCHHHHHHHHHHHHH	48.32	29967540
187	Phosphorylation	AYWKLVLSGRFKFLD HHHHHHHCCCCHHHH	22.05	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCNL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCNL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCNL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CUL1_HUMAN	CUL1	physical	23201271
CUL2_HUMAN	CUL2	physical	23201271
CUL3_HUMAN	CUL3	physical	23201271
CUL4A_HUMAN	CUL4A	physical	23201271
CUL4B_HUMAN	CUL4B	physical	23201271
CUL5_HUMAN	CUL5	physical	23201271
CUL1_HUMAN	CUL1	physical	19617556
CUL2_HUMAN	CUL2	physical	19617556
CUL3_HUMAN	CUL3	physical	19617556
CUL4A_HUMAN	CUL4A	physical	19617556
CUL4B_HUMAN	CUL4B	physical	19617556
CUL5_HUMAN	CUL5	physical	19617556
UBC12_HUMAN	UBE2M	physical	19617556
CUL1_HUMAN	CUL1	physical	26906416
CUL2_HUMAN	CUL2	physical	26906416
CUL3_HUMAN	CUL3	physical	26906416
CUL4A_HUMAN	CUL4A	physical	26906416
CUL4B_HUMAN	CUL4B	physical	26906416
CUL5_HUMAN	CUL5	physical	26906416
CAND1_HUMAN	CAND1	physical	26906416
RBX1_HUMAN	RBX1	physical	26906416
RBX2_HUMAN	RNF7	physical	26906416
ELOB_HUMAN	TCEB2	physical	26906416
UBC12_HUMAN	UBE2M	physical	26906416

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.