BL1S5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BL1S5_HUMAN
• UniProt AC: Q8TDH9
• Protein Name: Biogenesis of lysosome-related organelles complex 1 subunit 5
• Gene Name: BLOC1S5
• Organism: Homo sapiens (Human).
• Sequence Length: 187
• Protein Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking..
• Protein Sequence: MSGGGTETPVGCEAAPGGGSKKRDSLGTAGSAHLIIKDLGEIHSRLLDHRPVIQGETRYFVKEFEEKRGLREMRVLENLKNMIHETNEHTLPKCRDTMRDSLSQVLQRLQAANDSVCRLQQREQERKKIHSDHLVASEKQHMLQWDNFMKEQPNKRAEVDEEHRKAMERLKEQYAEMEKDLAKFSTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGGGTETP ------CCCCCCCCC		22199227
2	Acetylation	------MSGGGTETP ------CCCCCCCCC		19413330
6	Phosphorylation	--MSGGGTETPVGCE --CCCCCCCCCCCCC		22199227
8	Phosphorylation	MSGGGTETPVGCEAA CCCCCCCCCCCCCCC		22199227
20	Phosphorylation	EAAPGGGSKKRDSLG CCCCCCCCCCCCCCC		26074081
25	Phosphorylation	GGSKKRDSLGTAGSA CCCCCCCCCCCCCCC		23927012
28	Phosphorylation	KKRDSLGTAGSAHLI CCCCCCCCCCCCEEE		23927012
31	Phosphorylation	DSLGTAGSAHLIIKD CCCCCCCCCEEEECC		23927012
37	Ubiquitination	GSAHLIIKDLGEIHS CCCEEEECCHHHHHH		-
44	Phosphorylation	KDLGEIHSRLLDHRP CCHHHHHHHHHHCCC		24719451
62	Ubiquitination	GETRYFVKEFEEKRG CCCHHHHHHHHHHHC		-
80	Ubiquitination	MRVLENLKNMIHETN HHHHHHHHHHHHHHC		-
101	Phosphorylation	CRDTMRDSLSQVLQR HHHHHHHHHHHHHHH		25072903
103	Phosphorylation	DTMRDSLSQVLQRLQ HHHHHHHHHHHHHHH		27050516
131	Phosphorylation	QERKKIHSDHLVASE HHHHHHHHCCHHHHH		23312004
139	Ubiquitination	DHLVASEKQHMLQWD CCHHHHHHHHHHHHH		-
179	Acetylation	EQYAEMEKDLAKFST HHHHHHHHHHHHHCC		19822311
183	Acetylation	EMEKDLAKFSTF--- HHHHHHHHHCCC---		19822319

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BL1S5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BL1S5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BL1S5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BL1S2_HUMAN	BLOC1S2	physical	15102850
DTBP1_HUMAN	DTNBP1	physical	15102850
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.