TTLL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTLL7_HUMAN
• UniProt AC: Q6ZT98
• Protein Name: Tubulin polyglutamylase TTLL7 {ECO:0000305}
• Gene Name: TTLL7 {ECO:0000312|HGNC:HGNC:26242}
• Organism: Homo sapiens (Human).
• Sequence Length: 887
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, dendrite . Perikaryon . In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon.
• Protein Description: Polyglutamylase which preferentially modifies beta-tubulin. [PubMed: 25959773 Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules]
• Protein Sequence: MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTKVASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQGLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGIGPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	NTELPYQSTMKRKVR CCCCCCCHHHHHHHH	25.32	27251275
27	Phosphorylation	TELPYQSTMKRKVRK CCCCCCHHHHHHHHH	15.93	27251275
120	Phosphorylation	NMTKMIKSRPLDYTF HHHHHHHCCCCCCEE	28.36	24719451
156	Phosphorylation	KKKRKQKTFIVKPAN HHHHCCCCEEEECCC	18.99	23532336
171	Phosphorylation	GAMGHGISLIRNGDK CCCCCCEEEECCCCC	23.49	-
278	Phosphorylation	KRSIKWFTEFLQANQ HHHHHHHHHHHHHCH	25.39	-
367	Ubiquitination	QKIDYDVKRGVLLNA CCCCCHHHHHHHHHH	40.30	29967540
401	Phosphorylation	AEAQRRLYGQNSIKR HHHHHHHHCHHHHHH	18.17	30576142
405	Phosphorylation	RRLYGQNSIKRLLPG HHHHCHHHHHHHCCC	22.92	30576142
413	Phosphorylation	IKRLLPGSSDWEQQR HHHHCCCCCHHHHHH	24.16	-
414	Phosphorylation	KRLLPGSSDWEQQRH HHHCCCCCHHHHHHH	53.29	-
463	Ubiquitination	RIYPPEDKALLEKYE CCCCHHHHHHHHHHH	38.99	-
482	Phosphorylation	VAFQTFLSGRAASFQ HHHHHHHHCCHHHHH	23.26	24719451
487	Phosphorylation	FLSGRAASFQRELNN HHHCCHHHHHHHHCC	22.41	30301811
533	Phosphorylation	RGPKPLCSMPESTEI CCCCCCCCCCCCCCH	45.08	30206219
537	Phosphorylation	PLCSMPESTEIMKRP CCCCCCCCCCHHCCC	26.01	30206219
538	Phosphorylation	LCSMPESTEIMKRPK CCCCCCCCCHHCCCC	28.06	30206219
552	Phosphorylation	KYCSSDSSYDSSSSS CCCCCCCCCCCCCCC	37.64	30576142
553	Phosphorylation	YCSSDSSYDSSSSSS CCCCCCCCCCCCCCC	24.64	22468782
557	Phosphorylation	DSSYDSSSSSSESDE CCCCCCCCCCCCCCH	37.89	22468782
562	Phosphorylation	SSSSSSESDENEKEE CCCCCCCCCHHHHHH	52.77	30576142
580	Phosphorylation	KKREKQVTYNLKPSN HHHHHHCEECCCCCC	12.28	29978859
581	Phosphorylation	KREKQVTYNLKPSNH HHHHHCEECCCCCCC	21.46	29978859
586	Phosphorylation	VTYNLKPSNHYKLIQ CEECCCCCCCHHHCC	34.35	29978859
589	Phosphorylation	NLKPSNHYKLIQQPS CCCCCCCHHHCCCCC	16.25	29978859
628	Phosphorylation	FSAQQMISVSRPTSA CCHHHCCEECCCCCC	14.54	24719451
647	Phosphorylation	SLNRASSYMRHLPHS CHHHHHHHHHCCCCC	8.82	-
868	Phosphorylation	TPTYNLKYNSPGMTR CCCCCCEECCCCCCH	24.84	30631047
870	Phosphorylation	TYNLKYNSPGMTRSN CCCCEECCCCCCHHC	21.53	30631047
874	Phosphorylation	KYNSPGMTRSNVLFT EECCCCCCHHCEEEE	36.54	30631047
876	Phosphorylation	NSPGMTRSNVLFTSR CCCCCCHHCEEEEEC	23.32	22210691
881	Phosphorylation	TRSNVLFTSRYGHL- CHHCEEEEECCCCC-	14.24	22210691
882	Phosphorylation	RSNVLFTSRYGHL-- HHCEEEEECCCCC--	19.03	22210691
884	Phosphorylation	NVLFTSRYGHL---- CEEEEECCCCC----	14.52	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTLL7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTLL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTLL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CSK22_HUMAN	CSNK2A2	physical	28514442
ZMYM1_HUMAN	ZMYM1	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.