dbPTM

CF157_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CF157_HUMAN
UniProt AC	Q5JU67
Protein Name	Cilia- and flagella-associated protein 157 {ECO:0000305}
Gene Name	CFAP157 {ECO:0000312\|HGNC:HGNC:27843}
Organism	Homo sapiens (Human).
Sequence Length	520
Subcellular Localization	Cytoplasm, cytoskeleton, cilium basal body .
Protein Description	Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure..
Protein Sequence	MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGPPKESRPSIQLPRTGSLLPQLSDITPYQPGDLGLVPRQVHIPPNPQDLRLLSYITRVGTFRAHSSPEMRAPGSLKRLEKFSLPEVPLRPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
35	Acetylation	AVEPPLAKEMKEFYH EECCCCHHHHHHHHC	19666963
81	Ubiquitination	EQLANNKKEIVAFLK HHHHCCHHHHHHHHH	-
184	Phosphorylation	NEFRDYAYNLEKKSV HHHHHHHHHHHCCCC	22468782
312	Phosphorylation	EELRLLLSQLEQRSL HHHHHHHHHHHHHHH	-
444	Phosphorylation	PSIQLPRTGSLLPQL CCCCCCCCCCCCCCH	25693802
446	Phosphorylation	IQLPRTGSLLPQLSD CCCCCCCCCCCCHHC	25693802
489	Phosphorylation	SYITRVGTFRAHSSP HHHHCCCCCCCCCCC	24719451
494	Phosphorylation	VGTFRAHSSPEMRAP CCCCCCCCCCCCCCC	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CF157_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CF157_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CF157_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CF157_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CF157_HUMAN

Related Literatures of Post-Translational Modification