F184A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F184A_HUMAN
• UniProt AC: Q8NB25
• Protein Name: Protein FAM184A
• Gene Name: FAM184A
• Organism: Homo sapiens (Human).
• Sequence Length: 1140
• Protein Sequence: MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATPGMSWQQ -----CCCCCCCCCC	32.03	24043423
7	Phosphorylation	-MATPGMSWQQHYYG -CCCCCCCCCCCCCC	27.87	24043423
12	Phosphorylation	GMSWQQHYYGGSAAK CCCCCCCCCCCCCCC	10.24	24043423
13	Phosphorylation	MSWQQHYYGGSAAKF CCCCCCCCCCCCCCC	16.94	24043423
16	Phosphorylation	QQHYYGGSAAKFAPS CCCCCCCCCCCCCCC	22.23	24043423
23	Phosphorylation	SAAKFAPSPATAQLA CCCCCCCCHHHHHHC	24.60	24719451
36	Phosphorylation	LAGHSMDYSQEMHLK HCCCCCCCCHHHHHH	12.01	24275569
37	Phosphorylation	AGHSMDYSQEMHLKM CCCCCCCCHHHHHHH	18.52	24275569
45	Phosphorylation	QEMHLKMSKKIAQLT HHHHHHHHHHHHHHH	29.25	24275569
47	Ubiquitination	MHLKMSKKIAQLTKV HHHHHHHHHHHHHHH	35.65	-
61	Ubiquitination	VIYALNTKNDEHESA HHHHHHCCCHHHHHH	62.42	-
73	Ubiquitination	ESAIQALKDAHEEEI HHHHHHHHHHCHHHH	56.75	-
90	Ubiquitination	ILAETREKILQYKSK HHHHHHHHHHHHHHH	45.48	-
107	Ubiquitination	EELDLRRKIQVLESS HHHHHHHHHHHHHHH	30.93	-
127	Phosphorylation	KMKQQALTEFEAYKH HHHHHHHHHHHHHHH	41.46	29978859
132	Phosphorylation	ALTEFEAYKHRVEDM HHHHHHHHHHHHHHH	10.50	29978859
171	Phosphorylation	KFEEKLRSFGQLQVQ HHHHHHHHCCCCHHH	44.13	24260401
203	Ubiquitination	REIQELLKSQQDHSA HHHHHHHHHCCHHHH	59.86	-
229	Phosphorylation	LHRMEVESLNKMLEE HHHHHHHHHHHHHHH	42.28	25850435
254	Ubiquitination	DYEGKLNKAQSFYER HHCHHHHHHHHHHHH	59.23	-
307	Phosphorylation	KTIGKLKTELQMVQD HHHHHHHHHHHHHHH	52.98	28509920
318	Phosphorylation	MVQDEAGSLLDKCQK HHHHHHHHHHHHHHH	32.57	28509920
359	Ubiquitination	MALLSKHKEVESELA HHHHHHHHHHHHHHH	68.16	-
392	Phosphorylation	HIGMLQATQMTQEVT HHHHHHHHHCCEEEE	13.10	-
395	Phosphorylation	MLQATQMTQEVTIKD HHHHHHCCEEEEHHH	16.26	-
415	Phosphorylation	SRVNERLSQLEEERA HHHHHHHHHHHHHHH	38.65	-
427	Ubiquitination	ERAFLRSKTQSLDEE HHHHHHHHCCCCCHH	44.12	-
436	Ubiquitination	QSLDEEQKQQILELE CCCCHHHHHHHHHHH	47.66	-
462	Ubiquitination	EYYERELKNLQSRLE HHHHHHHHHHHHHHH	51.35	-
473	Phosphorylation	SRLEEEVTQLNEAHS HHHHHHHHHHHHHHH	30.53	29083192
480	Phosphorylation	TQLNEAHSKTLEELA HHHHHHHHHHHHHHH	34.09	29083192
527	Ubiquitination	KLNLEEDKNQLQQEL CCCHHHHHHHHHHHH	50.28	-
561	Ubiquitination	HLQDMVRKSEQGLGS HHHHHHHHHHCCCCC	47.11	-
591	Ubiquitination	QNELDLTKDSLKETK HHHHHCCHHHHHHHH	53.25	-
698	Phosphorylation	EDLLNQISLLKQNLE HHHHHHHHHHHHHHH	20.20	24719451
776	Ubiquitination	LENHLQQKHSAELQS HHHHHHHHHHHHHHH	26.94	-
785	Ubiquitination	SAELQSLKDAHRESM HHHHHHHHHHHHHHH	59.10	-
820	Phosphorylation	EGKAMLASLRSELNH HHHHHHHHHHHHHHH	21.98	24719451
823	Phosphorylation	AMLASLRSELNHQHA HHHHHHHHHHHHHHH	52.29	24043423
941	Phosphorylation	EKELDVMTADHLREK HHHHHHHCHHHHHHH	28.87	24905233
941	Ubiquitination	EKELDVMTADHLREK HHHHHHHCHHHHHHH	28.87	21890473
1024	Methylation	YQLELVNRETNFNKV EEEEECCCCCCHHHH	44.64	-
1026 (in isoform 2)	Ubiquitination	-	41.70	21890473
1030	Ubiquitination	NRETNFNKVFNSSPT CCCCCHHHHCCCCCC	44.03	-
1035	Phosphorylation	FNKVFNSSPTVGVIN HHHHCCCCCCCCCCC	26.20	24719451
1097	Phosphorylation	HDIEFNSSKPLPQPV CCCCCCCCCCCCCCC	39.12	24719451
1110	Ubiquitination	PVPPKGPKTFLSPAQ CCCCCCCCCCCCHHH	61.65	21890473
1110 (in isoform 1)	Ubiquitination	-	61.65	21890473
1118	Phosphorylation	TFLSPAQSEASPVAS CCCCHHHCCCCCCCC	36.92	24850871
1125	Phosphorylation	SEASPVASPDPQRQE CCCCCCCCCCHHHHH	30.03	24850871

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F184A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F184A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F184A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.