DCAF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCAF4_HUMAN
• UniProt AC: Q8WV16
• Protein Name: DDB1- and CUL4-associated factor 4
• Gene Name: DCAF4
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MNKSRWQSRRRHGRRSHQQNPWFRLRDSEDRSDSRAAQPAHDSGHGDDESPSTSSGTAGTSSVPELPGFYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMESKRLRLLQEEDRRKKIARMGFNASSMLRKSQLGFLNVTNYCHLAHELRLSCMERKKVQIRSMDPSALASDRFNLILADTNSDRLFTVNDVKVGGSKYGIINLQSLKTPTLKVFMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVNSHPGIDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFGTNSDVLAQQFALMAPLLFNGCRSGEIFAIDLRCGNQGKGWKATRLFHDSAVTSVRILQDEQYLMASDMAGKIKLWDLRTTKCVRQYEGHVNEYAYLPLHVHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSPYPASKADIPSVAFSSRLGGSRGAPGLLMAVGQDLYCYSYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	RRRHGRRSHQQNPWF HHHHCCCCCCCCCCC	25.04	28555341
108	Ubiquitination	MESKRLRLLQEEDRR HHHHHHHHHHHHHHH	7.38	21890473
127	Phosphorylation	RMGFNASSMLRKSQL HCCCCHHHHHHHHHC	21.30	19664995
147	Ubiquitination	TNYCHLAHELRLSCM HCHHHHHHHHHHHHH	40.77	21890473
163	Phosphorylation	RKKVQIRSMDPSALA HCCCEEECCCHHHHH	29.21	25404012
167	Phosphorylation	QIRSMDPSALASDRF EEECCCHHHHHCCCC	31.48	25404012
171	Phosphorylation	MDPSALASDRFNLIL CCHHHHHCCCCCEEE	30.12	25404012
208 (in isoform 2)	Ubiquitination	-	58.67	21890473
208 (in isoform 1)	Ubiquitination	-	58.67	21890473
208	Ubiquitination	IINLQSLKTPTLKVF EEECHHCCCCCEEEE	58.67	-
279	Phosphorylation	DRPGMLCSFRIPGAW CCCCEEEEEECCCCE	17.38	24719451
360	Acetylation	LRCGNQGKGWKATRL EECCCCCCCCEEEEE	52.40	25953088
384	Phosphorylation	RILQDEQYLMASDMA EEECCHHHHHHCCCC	9.08	22817900
388	Phosphorylation	DEQYLMASDMAGKIK CHHHHHHCCCCCCEE	17.60	22964224
460	Ubiquitination	PSPYPASKADIPSVA CCCCCCCCCCCCCHH	52.78	2190698
460 (in isoform 1)	Ubiquitination	-	52.78	21890473
465	Phosphorylation	ASKADIPSVAFSSRL CCCCCCCCHHCCCCC	26.81	26270265
465	O-linked_Glycosylation	ASKADIPSVAFSSRL CCCCCCCCHHCCCCC	26.81	30379171
469	Phosphorylation	DIPSVAFSSRLGGSR CCCCHHCCCCCCCCC	12.57	24719451
470	Phosphorylation	IPSVAFSSRLGGSRG CCCHHCCCCCCCCCC	25.68	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCAF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCAF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCAF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX30_HUMAN	SOX30	physical	21988832
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
CUL4B_HUMAN	CUL4B	physical	16949367
CUL4A_HUMAN	CUL4A	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
CSN1_HUMAN	GPS1	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
DDB1_HUMAN	DDB1	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
CLU_HUMAN	CLUH	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.