dbPTM

DOCK9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOCK9_HUMAN
UniProt AC	Q9BZ29
Protein Name	Dedicator of cytokinesis protein 9 {ECO:0000305}
Gene Name	DOCK9 {ECO:0000312\|HGNC:HGNC:14132}
Organism	Homo sapiens (Human).
Sequence Length	2069
Subcellular Localization	Endomembrane system . Associated with membranes.
Protein Description	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation..
Protein Sequence	MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQLG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQPPLLPA ------CCCCCCCCC	63.80	20068231
10	Phosphorylation	QPPLLPASAETRKFT CCCCCCCCHHHHHHH	25.38	22199227
13	Phosphorylation	LLPASAETRKFTRAL CCCCCHHHHHHHHHH	38.59	22199227
17	Phosphorylation	SAETRKFTRALSKPG CHHHHHHHHHHCCCC	20.33	20068231
21	Phosphorylation	RKFTRALSKPGTAAE HHHHHHHCCCCCHHH	35.50	19664994
21 (in isoform 5)	Phosphorylation	-	35.50	22199227
21 (in isoform 6)	Phosphorylation	-	35.50	22199227
25	Phosphorylation	RALSKPGTAAELRQS HHHCCCCCHHHHHHH	31.08	23927012
25 (in isoform 5)	Phosphorylation	-	31.08	26852163
25 (in isoform 6)	Phosphorylation	-	31.08	26852163
32	Phosphorylation	TAAELRQSVSEVVRG CHHHHHHHHHHHHHH	22.60	23403867
34	Phosphorylation	AELRQSVSEVVRGSV HHHHHHHHHHHHHCH	29.89	23403867
37 (in isoform 5)	Phosphorylation	-	5.14	26657352
37 (in isoform 6)	Phosphorylation	-	5.14	26657352
40	Phosphorylation	VSEVVRGSVLLAKPK HHHHHHHCHHHCCCC	10.06	23312004
54	Phosphorylation	KLIEPLDYENVIVQK CCCCCCCCCCEEHHC	19.65	-
61	Ubiquitination	YENVIVQKKTQILND CCCEEHHCHHHHHHH	47.06	-
96	Phosphorylation	QGRYICSTVPAKAEE CCCEEEECCCCCHHH	26.54	22798277
119	Phosphorylation	ECIKTYNSDWHLVNY HHHHHHCCCEEEEEE	31.50	23898821
147	Ubiquitination	NKVVKLDKLPVHVYE CCEEECCCCCEEEEE	66.19	-
153	Phosphorylation	DKLPVHVYEVDEEVD CCCCEEEEECCCCCC	8.71	20873877
167	Phosphorylation	DKDEDAASLGSQKGG CCCCCHHHCCCCCCC	34.68	22617229
170	Phosphorylation	EDAASLGSQKGGITK CCHHHCCCCCCCEEC	33.73	20873877
176	Phosphorylation	GSQKGGITKHGWLYK CCCCCCEECCEEEEC	21.91	23312004
229	Phosphorylation	ISKEPKGSIFLDSCM CCCCCCCCEEHHHHH	19.12	23607784
234	Phosphorylation	KGSIFLDSCMGVVQN CCCEEHHHHHHHHHC	14.24	23607784
308	Phosphorylation	EQSKLEGSGSGLDSY HHHHHCCCCCCHHHH	22.02	23403867
310	Phosphorylation	SKLEGSGSGLDSYLP HHHCCCCCCHHHHHH	37.57	23403867
314	Phosphorylation	GSGSGLDSYLPELAK CCCCCHHHHHHHHHH	33.34	23403867
315	Phosphorylation	SGSGLDSYLPELAKS CCCCHHHHHHHHHHH	26.41	23403867
332	Phosphorylation	EAEIKLKSESRVKLF HCCCEECCCCCEEEE	51.76	24719451
334	Phosphorylation	EIKLKSESRVKLFYL CCEECCCCCEEEEEE	49.84	24719451
340	Phosphorylation	ESRVKLFYLDPDAQK CCCEEEEEECCCHHH	22.19	-
347	Ubiquitination	YLDPDAQKLDFSSAE EECCCHHHCCCCCCC	52.31	-
351	Phosphorylation	DAQKLDFSSAEPEVK CHHHCCCCCCCHHHH	28.45	21815630
352	Phosphorylation	AQKLDFSSAEPEVKS HHHCCCCCCCHHHHH	36.32	27251275
358	Ubiquitination	SSAEPEVKSFEEKFG CCCCHHHHHHHHHHC	48.00	-
359	Phosphorylation	SAEPEVKSFEEKFGK CCCHHHHHHHHHHCC	42.96	24719451
363	Ubiquitination	EVKSFEEKFGKRILV HHHHHHHHHCCEEEE	52.82	-
431	Phosphorylation	SVRQMLATTSPALMN CHHHHHHHCCCHHHC	24.68	23403867
432	Phosphorylation	VRQMLATTSPALMNG HHHHHHHCCCHHHCC	27.40	23403867
433	Phosphorylation	RQMLATTSPALMNGS HHHHHHCCCHHHCCC	12.10	23403867
440	Phosphorylation	SPALMNGSGQSPSVL CCHHHCCCCCCHHHH	28.76	28102081
443	Phosphorylation	LMNGSGQSPSVLKGI HHCCCCCCHHHHHHH	23.75	22617229
445	Phosphorylation	NGSGQSPSVLKGILH CCCCCCHHHHHHHHH	45.38	28102081
465	Phosphorylation	YPKQGIFSVTCPHPD CCCCCEEEEECCCCC	18.01	28188228
467	Phosphorylation	KQGIFSVTCPHPDIF CCCEEEEECCCCCEE	21.08	28188228
496	Methylation	HCAEPYMKSSDSSKV CCCCCCCCCCCCHHH	40.75	-
498	Phosphorylation	AEPYMKSSDSSKVAQ CCCCCCCCCCHHHHH	35.67	23532336
731	Phosphorylation	EKHHLLLTFFHVSCD HHCCEEEEEEEECCC	24.99	27251275
736	Phosphorylation	LLTFFHVSCDNSSKG EEEEEEECCCCCCCC	13.74	27251275
740	Phosphorylation	FHVSCDNSSKGSTKK EEECCCCCCCCCCCC	21.85	27251275
741	Phosphorylation	HVSCDNSSKGSTKKR EECCCCCCCCCCCCC	47.49	27251275
744	Phosphorylation	CDNSSKGSTKKRDVV CCCCCCCCCCCCCEE	40.57	27251275
745	Phosphorylation	DNSSKGSTKKRDVVE CCCCCCCCCCCCEEE	49.61	27251275
753	Phosphorylation	KKRDVVETQVGYSWL CCCCEEEECCCCCEE	19.56	-
757	Phosphorylation	VVETQVGYSWLPLLK EEEECCCCCEEEEEC	9.60	-
758	Phosphorylation	VETQVGYSWLPLLKD EEECCCCCEEEEECC	19.06	-
880	Phosphorylation	NQLFRVLTRATQEEV HHHHHHHHHCCHHHH	18.53	18491316
883	Phosphorylation	FRVLTRATQEEVAVN HHHHHHCCHHHHHHH	32.97	18491316
913	Phosphorylation	GLESHLRSYVKYAYK HHHHHHHHHHHHHHH	40.41	20068231
914	Phosphorylation	LESHLRSYVKYAYKA HHHHHHHHHHHHHHC	8.43	20068231
917	Phosphorylation	HLRSYVKYAYKAEPY HHHHHHHHHHHCCCE	12.72	20068231
919	Phosphorylation	RSYVKYAYKAEPYVA HHHHHHHHHCCCEEC	13.98	29978859
924	Phosphorylation	YAYKAEPYVASEYKT HHHHCCCEECCCCCH	10.51	26657352
927	Phosphorylation	KAEPYVASEYKTVHE HCCCEECCCCCHHHH	31.26	19664994
929	Phosphorylation	EPYVASEYKTVHEEL CCEECCCCCHHHHHH	14.95	21712546
931	Phosphorylation	YVASEYKTVHEELTK EECCCCCHHHHHHHH	26.62	23403867
937	Phosphorylation	KTVHEELTKSMTTIL CHHHHHHHHHHHHCC	25.09	23403867
939	Phosphorylation	VHEELTKSMTTILKP HHHHHHHHHHHCCCC	19.00	29978859
941	Phosphorylation	EELTKSMTTILKPSA HHHHHHHHHCCCCCC	20.13	29978859
942	Phosphorylation	ELTKSMTTILKPSAD HHHHHHHHCCCCCCC	18.70	29978859
970	Phosphorylation	FFDVLIKSMAQHLIE HHHHHHHHHHHHHHH	16.62	22210691
1059	Sumoylation	CFAPGDPKTLFEYKF EECCCCCHHHHEEEE	63.70	-
1186	Phosphorylation	RINVRDVSPFPVNAG CCCCCCCCCCCCCCC	25.72	17192257
1200	Phosphorylation	GMTVKDESLALPAVN CCCCCCCCCCCCCCC	29.13	21712546
1211	Phosphorylation	PAVNPLVTPQKGSTL CCCCCCCCCCCCCCC	27.90	21815630
1216	Phosphorylation	LVTPQKGSTLDNSLH CCCCCCCCCCCCHHH	32.60	29396449
1217	Phosphorylation	VTPQKGSTLDNSLHK CCCCCCCCCCCHHHH	46.96	21815630
1221	Phosphorylation	KGSTLDNSLHKDLLG CCCCCCCHHHHHHHH	31.36	21815630
1231	Phosphorylation	KDLLGAISGIASPYT HHHHHHHHCCCCCCC	24.50	23403867
1235	Phosphorylation	GAISGIASPYTTSTP HHHHCCCCCCCCCCC	19.27	25159151
1237	Phosphorylation	ISGIASPYTTSTPNI HHCCCCCCCCCCCCC	21.83	23403867
1238	Phosphorylation	SGIASPYTTSTPNIN HCCCCCCCCCCCCCC	20.04	23403867
1239	Phosphorylation	GIASPYTTSTPNINS CCCCCCCCCCCCCCC	25.43	23403867
1240	Phosphorylation	IASPYTTSTPNINSV CCCCCCCCCCCCCCC	33.78	23403867
1241	Phosphorylation	ASPYTTSTPNINSVR CCCCCCCCCCCCCCC	20.47	25159151
1246	Phosphorylation	TSTPNINSVRNADSR CCCCCCCCCCCCCCC	20.75	23403867
1252	Phosphorylation	NSVRNADSRGSLIST CCCCCCCCCCCCEEC	35.81	26657352
1255	Phosphorylation	RNADSRGSLISTDSG CCCCCCCCCEECCCC	22.78	19664994
1258	Phosphorylation	DSRGSLISTDSGNSL CCCCCCEECCCCCCC	31.30	29255136
1259	Phosphorylation	SRGSLISTDSGNSLP CCCCCEECCCCCCCC	27.47	29255136
1261	Phosphorylation	GSLISTDSGNSLPER CCCEECCCCCCCCCC	39.71	23403867
1264	Phosphorylation	ISTDSGNSLPERNSE EECCCCCCCCCCCCC	49.15	10470851
1270	Phosphorylation	NSLPERNSEKSNSLD CCCCCCCCCCCCCCC	53.26	23898821
1273	Phosphorylation	PERNSEKSNSLDKHQ CCCCCCCCCCCCHHH	27.83	30278072
1275	Phosphorylation	RNSEKSNSLDKHQQS CCCCCCCCCCHHHHH	45.06	23401153
1282	Phosphorylation	SLDKHQQSSTLGNSV CCCHHHHHCCCCCCE	20.79	23403867
1283	Phosphorylation	LDKHQQSSTLGNSVV CCHHHHHCCCCCCEE	24.26	23403867
1284	Phosphorylation	DKHQQSSTLGNSVVR CHHHHHCCCCCCEEE	43.88	23401153
1288	Phosphorylation	QSSTLGNSVVRCDKL HHCCCCCCEEECCCC	21.86	23403867
1327	Phosphorylation	FTYWNKASTSELMDF HHCCCCCCHHHHHHH	33.79	21406692
1328	Phosphorylation	TYWNKASTSELMDFF HCCCCCCHHHHHHHH	30.95	21406692
1329	Phosphorylation	YWNKASTSELMDFFT CCCCCCHHHHHHHHH	26.66	21406692
1336	Phosphorylation	SELMDFFTISEVCLH HHHHHHHHHHHHHHH	24.48	21406692
1338	Phosphorylation	LMDFFTISEVCLHQF HHHHHHHHHHHHHHH	22.40	21406692
1347	Phosphorylation	VCLHQFQYMGKRYIA HHHHHHHHCCHHHHH	14.77	21406692
1352	Phosphorylation	FQYMGKRYIARTGMM HHHCCHHHHHHHCCH	11.47	21406692
1356	Phosphorylation	GKRYIARTGMMHARL CHHHHHHHCCHHHHH	22.02	20068231
1468	Phosphorylation	YKFPSTFYEGRADMC HHCCCCCCCCCHHHH	19.98	-
1480	Phosphorylation	DMCAALCYEILKCCN HHHHHHHHHHHHHCC	13.57	-
1491	Phosphorylation	KCCNSKLSSIRTEAS HHCCCCCHHHHHHHH	27.70	30301811
1492	Phosphorylation	CCNSKLSSIRTEASQ HCCCCCHHHHHHHHH	26.90	25954137
1567	Phosphorylation	IKHTSFSSDVKDLTK HHCCCCCHHHHHHHH	44.40	-
1573	Phosphorylation	SSDVKDLTKRIRTVL CHHHHHHHHHHHHHH	28.54	22468782
1578	Phosphorylation	DLTKRIRTVLMATAQ HHHHHHHHHHHHHHH	18.67	21406692
1583	Phosphorylation	IRTVLMATAQMKEHE HHHHHHHHHHHHHHC	11.94	21406692
1601	Phosphorylation	EMLVDLQYSLAKSYA HHHHHHHHHHHHHHC	16.98	28111955
1602	Phosphorylation	MLVDLQYSLAKSYAS HHHHHHHHHHHHHCC	14.64	28111955
1607	Phosphorylation	QYSLAKSYASTPELR HHHHHHHHCCCHHHH	12.13	-
1610	Phosphorylation	LAKSYASTPELRKTW HHHHHCCCHHHHHHH	16.77	24719451
1616	Phosphorylation	STPELRKTWLDSMAR CCHHHHHHHHHHHCC	25.48	24719451
1747	2-Hydroxyisobutyrylation	LIIPIYEKRRDFERL HHHHHHHHHCCHHHH	35.44	-
1769	Phosphorylation	HRAYSKVTEVMHSGR HHHHHHHHHHHHHHH	26.97	27499020
1774	Phosphorylation	KVTEVMHSGRRLLGT HHHHHHHHHHHHHHH	18.85	25159151
1817	Phosphorylation	EDGKEYIYKEPKLTP CCCCEEEEECCCCCC	14.38	25332170
1826	Phosphorylation	EPKLTPLSEISQRLL CCCCCCHHHHHHHHH	33.80	25332170
1834	Methylation	EISQRLLKLYSDKFG HHHHHHHHHHHCCCC	50.39	-
1842	Phosphorylation	LYSDKFGSENVKMIQ HHHCCCCCCCCEEEE	29.18	29083192
1930	Phosphorylation	TAIHCFPYVKKRIPV HHHHHHHHHHHHCCC	12.49	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOCK9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOCK9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOCK9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SMAD2_HUMAN	SMAD2	physical	18729074
SMAD3_HUMAN	SMAD3	physical	18729074

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOCK9_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1186, AND MASSSPECTROMETRY.	18691976 [Abstract]