KDM4D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM4D_HUMAN
• UniProt AC: Q6B0I6
• Protein Name: Lysine-specific demethylase 4D
• Gene Name: KDM4D
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate..
• Protein Sequence: METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METMKSKANC -----CCCHHHHCCC	28.71	22210691
6	Phosphorylation	--METMKSKANCAQN --CCCHHHHCCCCCC	26.61	22210691
26	ADP-ribosylation	MIFHPTKEEFNDFDK EEECCCHHHHCCHHH	71.01	23102699
26	PolyADP-ribosyl glutamic acid	MIFHPTKEEFNDFDK EEECCCHHHHCCHHH	71.01	-
27	PolyADP-ribosyl glutamic acid	IFHPTKEEFNDFDKY EECCCHHHHCCHHHH	51.83	-
27	ADP-ribosylation	IFHPTKEEFNDFDKY EECCCHHHHCCHHHH	51.83	23102699
33	Ubiquitination	EEFNDFDKYIAYMES HHHCCHHHHHHHHHH	38.25	29967540
55	Ubiquitination	LAKIIPPKEWKARET CCCCCCCHHHHHHHH	71.50	-
94	Ubiquitination	TQYHKKKKAMTVGEY HHHHHHCCCCCHHHH	52.88	-
303	Phosphorylation	ATPRWIDYGKMASQC CCCCCCCHHHHHHCC	14.98	-
362	Ubiquitination	SQELSTQKEVQLPRR HHHCCCCCCCCCCHH	61.00	-
395	Phosphorylation	PMAARSGTRCHTLVC CCCCCCCCCEEEEEE	31.22	-
403	Phosphorylation	RCHTLVCSSLPRRSA CEEEEEECCCCCCCC	27.68	29262532
404	Phosphorylation	CHTLVCSSLPRRSAV EEEEEECCCCCCCCC	36.95	24719451
409	Phosphorylation	CSSLPRRSAVSGTAT ECCCCCCCCCCCCCC	34.01	19007248
412	Phosphorylation	LPRRSAVSGTATQPR CCCCCCCCCCCCCCC	30.09	22210691
414	Phosphorylation	RRSAVSGTATQPRAA CCCCCCCCCCCCCCC	21.01	22210691
416	Phosphorylation	SAVSGTATQPRAAAV CCCCCCCCCCCCCCC	38.66	-
469	Phosphorylation	AQELTLQTPAKRPLL HHEEECCCCCCCCCC	28.46	28555341
505	Phosphorylation	MDKPVPLSPGLQHPV CCCCCCCCCCCCCCC	15.73	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM4D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM4D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM4D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM4D_HUMAN	KDM4D	physical	17207460
ANDR_HUMAN	AR	physical	17555712
P53_HUMAN	TP53	physical	22514644

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.
PubMed: 19007248