DCA12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCA12_HUMAN
• UniProt AC: Q5T6F0
• Protein Name: DDB1- and CUL4-associated factor 12
• Gene Name: DCAF12
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RKRKAPASPGAGSDA CCCCCCCCCCCCCCC	23.86	23401153
20	Phosphorylation	PASPGAGSDAQGPQF CCCCCCCCCCCCCCC	29.28	23927012
32	Phosphorylation	PQFGWDHSLHKRKRL CCCCCCCCCCCCCCC	29.69	23927012
35	Ubiquitination	GWDHSLHKRKRLPPV CCCCCCCCCCCCCCC	65.98	29967540
77	Phosphorylation	YAAQQLPSLLKEREF HHHHHHHHHHHHCCC	55.73	18491316
80	Ubiquitination	QQLPSLLKEREFHLG HHHHHHHHHCCCHHH	61.08	29967540
107	Phosphorylation	HRQVVCGTKCNTLFV CCEEEECCCCCEEEE	27.57	-
219	Ubiquitination	VTDDVLTKSDARHNV ECCCEECHHHHCCCC	42.02	2190698
232	Phosphorylation	NVSRVPVYAHITHKA CCCCCCEEEEHHHHH	6.08	27642862
238	Ubiquitination	VYAHITHKALKDIPK EEEEHHHHHHCCCCC	46.92	29967540
241	Ubiquitination	HITHKALKDIPKEDT EHHHHHHCCCCCCCC	59.48	-
254	Ubiquitination	DTNPDNCKVRALAFN CCCCCCCEEEEEEEC	40.80	29967540
263	Ubiquitination	RALAFNNKNKELGAV EEEEECCCCCCCCEE	71.19	29967540
265	Ubiquitination	LAFNNKNKELGAVSL EEECCCCCCCCEEEE	56.79	-
271	Phosphorylation	NKELGAVSLDGYFHL CCCCCEEEECCHHHH	21.87	-
275	Phosphorylation	GAVSLDGYFHLWKAE CEEEECCHHHHHHHH	6.36	-
287	Ubiquitination	KAENTLSKLLSTKLP HHHHHHHHHHHCCCC	57.47	29967540
290	Phosphorylation	NTLSKLLSTKLPYCR HHHHHHHHCCCCCCC	33.65	24719451
292	Ubiquitination	LSKLLSTKLPYCREN HHHHHHCCCCCCCCC	44.05	-
292	Acetylation	LSKLLSTKLPYCREN HHHHHHCCCCCCCCC	44.05	25953088
383	Phosphorylation	RLSACYGSKPRLAGE HHHHHHCCCCCCCCC	17.01	-
384	Acetylation	LSACYGSKPRLAGEN HHHHHCCCCCCCCCC	29.78	25953088
384	Ubiquitination	LSACYGSKPRLAGEN HHHHHCCCCCCCCCC	29.78	-
393	Ubiquitination	RLAGENLKLTTGKGW CCCCCCCEECCCCCC	56.20	33845483
398	Ubiquitination	NLKLTTGKGWLNHDE CCEECCCCCCCCCCH	44.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCA12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCA12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCA12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB1_HUMAN	DDB1	physical	16949367
TBA3C_HUMAN	TUBA3C	physical	28514442
MCMBP_HUMAN	MCMBP	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
XIAP_HUMAN	XIAP	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
BIRC6_HUMAN	BIRC6	physical	28514442
YYAP1_HUMAN	YY1AP1	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.