| UniProt ID | KAD9_HUMAN | |
|---|---|---|
| UniProt AC | Q5TCS8 | |
| Protein Name | Adenylate kinase 9 | |
| Gene Name | AK9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1911 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.. | |
| Protein Sequence | MTSQEKTEEYPFADIFDEDETERNFLLSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDAMTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIENHRKKKKEAQKDGKGEEEEEEEEQEEEEAFIAEMQMVAEILHHLVQRPEDYLENVENIVKLYKETILQTLEEVMAEHNPQYLIELNGNKPAEELFMIVMDRLKYLNLKRAAILTKLQGAEEEINDTMENDELFRTLASYKLIAPRYRWQRSKWGRTCPVNLKDGNIYSGLPDYSVSFLGKIYCLSSEEALKPFLLNPRPYLLPPMPGPPCKVFILGPQYSGKTTLCNMLAENYKGKVVDYAQLVQPRFDKARETLVENTIAEATAAAIKVVKEKLLRELQARKQAETALREFQRQYEKMEFGVFPMEATHSSIDEEGYIQGSQRDRGSSLVDTEEAKTKSENVLHDQAAKVDKDDGKETGETFTFKRHSQDASQDVKLYSDTAPTEDLIEEVTADHPEVVTMIEETIKMSQDINFEQPYEKHAEILQEVLGEVMEENKDRFPGAPKYGGWIVDNCPIVKELWMALIKKGIIPDLVIYLSDTENNGKCLFNRIYLQKKSEIDSKILERLLEELQKKKKEEEEARKATEEELRLEEENRRLLELMKVKAKEAEETDNEDEEEIEGDELEVHEEPEASHDTRGSWLPEEFEASEVPETEPEAVSEPIEETTVETEIPKGSKEGLEIEKLSETVVLPEFPEDSYPDVPEMEPFKEKIGSFIILWKQLEATISEAYIKILNLEIADRTPQELLQKVVETMEKPFQYTAWELTGEDYEEETEDYQTEAEVDEELEEEEEEEGEDKMKERKRHLGDTKHFCPVVLKENFILQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEEPLKAPPLRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIEKWKLKQKKKLERKKLIKDMKAKIRVDTIAKRRAELILERDKKRRENVVRDDEEISEEELEEDNDDIENILEDEFPKDEEEMSGEEDEEQETDAIERLRGELGEKFEADTHNLQIIQDELERYLIPIISINGARRNHIVQYTLNMKLKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQPKPKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPYPLHNSAQIVAVNNVKYRKNIGEIRQYYQEQHQNWYVIDGFHSKWWVWNEVIKNVQMVNKYMQTYLERIKAGKAACIDKLCITPQELLSRLGEFEQFCPVSLAESQELFDCSATDSLEFAAEFRGHYYKMSSQEKLNKFLENPELYVPPLAPHPLPSADMIPKRLTLSELKSRFPKCAELQGYCPVTYKDGNQRYEALVPGSINYALEYHNRIYICENKEKLQKFLRSPLKYWEQKLPHKLPPLREPILLTSLPLPGYLEQGIATSLIKAMNAAGCLKPKFPFLSIRRSALLYIALHLKAFNPKGSEYTRKKYKKKMEQFMESCELITYLGAKMTRKYKEPQFRAIDFDHKLKTFLSLRNIDPING | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Ubiquitination | RYITQAWKCIRVEAL HHHHHHHHHHEEEHH | - | ||
| 82 | Ubiquitination | SGVMLQSMLISGQSI CCCEEEHHHHCCCCC | 21963094 | ||
| 148 | Ubiquitination | PDVIINIKCPDYDLC CCEEEEEECCCCCHH | - | ||
| 169 | Phosphorylation | RQHNNTGYIYSRDQW CCCCCCCCEEECCCC | 18083107 | ||
| 172 | Phosphorylation | NNTGYIYSRDQWDPE CCCCCEEECCCCCHH | 24719451 | ||
| 297 | Ubiquitination | KRAAILTKLQGAEEE HHHHHHHHHHCCHHH | 21963094 | ||
| 322 | Ubiquitination | FRTLASYKLIAPRYR HHHHHHHCCCCCCHH | - | ||
| 344 | Ubiquitination | RTCPVNLKDGNIYSG CCCCCCCCCCCCCCC | - | ||
| 369 | Ubiquitination | KIYCLSSEEALKPFL EEEECCCHHHHHHHH | 21963094 | ||
| 401 | Phosphorylation | VFILGPQYSGKTTLC EEEECCCCCCHHHHH | 46161605 | ||
| 415 | Phosphorylation | CNMLAENYKGKVVDY HHHHHHHCCCCCCCH | 25884760 | ||
| 436 | Phosphorylation | RFDKARETLVENTIA CCHHHHHHHHHHHHH | 68733983 | ||
| 510 | Phosphorylation | GSQRDRGSSLVDTEE CCCCCCCCCCCCHHH | 30622161 | ||
| 511 | Phosphorylation | SQRDRGSSLVDTEEA CCCCCCCCCCCHHHH | 30622161 | ||
| 541 | O-linked_Glycosylation | DKDDGKETGETFTFK CCCCCCCCCCEEEEE | 30379171 | ||
| 551 | Phosphorylation | TFTFKRHSQDASQDV EEEEEECCCCCCCCC | 30622161 | ||
| 724 (in isoform 1) | Phosphorylation | - | - | ||
| 799 | Phosphorylation | ETEIPKGSKEGLEIE EEECCCCCCCCCEEE | 46161585 | ||
| 865 | Phosphorylation | NLEIADRTPQELLQK CHHHCCCCHHHHHHH | 50564439 | ||
| 957 | Phosphorylation | NTEEAAKYREKIYYF CHHHHHHHHHHHEEE | 18357099 | ||
| 1046 | Phosphorylation | GPEFEEDSENEQAAK CCCCCCCCCCHHHHH | 30622161 | ||
| 1193 | Phosphorylation | KAKIRVDTIAKRRAE HHHHHHHHHHHHHHH | 23403867 | ||
| 1306 | Phosphorylation | RRNHIVQYTLNMKLK CCCCHHEEECCCCCH | 46161597 | ||
| 1307 | Phosphorylation | RNHIVQYTLNMKLKP CCCHHEEECCCCCHH | 46161589 | ||
| 1425 | Phosphorylation | GPPKSGKTTVAKKIT CCCCCCCCCHHHHHH | 27251275 | ||
| 1426 | Phosphorylation | PPKSGKTTVAKKITS CCCCCCCCHHHHHHC | 27251275 | ||
| 1441 | Phosphorylation | EYGLKHLSIGGALRY HHCCCCCCHHHHHHH | 30631047 | ||
| 1514 | Phosphorylation | MNLLEARSIIPMVIF HHHHHHHCCCCEEEE | 29083192 | ||
| 1524 | Phosphorylation | PMVIFELSVPSKEIF CEEEEECCCCCHHHH | 29083192 | ||
| 1527 | Phosphorylation | IFELSVPSKEIFKRL EEECCCCCHHHHHHH | 29083192 | ||
| 1561 | Acetylation | IVAVNNVKYRKNIGE EEEEECEEECCCHHH | 25038526 | ||
| 1606 | Phosphorylation | NVQMVNKYMQTYLER HHHHHHHHHHHHHHH | 25003641 | ||
| 1609 | Phosphorylation | MVNKYMQTYLERIKA HHHHHHHHHHHHHHC | 25003641 | ||
| 1610 | Phosphorylation | VNKYMQTYLERIKAG HHHHHHHHHHHHHCC | 25003641 | ||
| 1634 | Phosphorylation | ITPQELLSRLGEFEQ CCHHHHHHHHCCHHH | 24719451 | ||
| 1711 | Phosphorylation | DMIPKRLTLSELKSR CCCCCCCCHHHHHHH | 21964256 | ||
| 1711 | O-linked_Glycosylation | DMIPKRLTLSELKSR CCCCCCCCHHHHHHH | 30379171 | ||
| 1740 | Phosphorylation | YKDGNQRYEALVPGS EECCCEEEEEECCCC | 25907765 | ||
| 1747 | Phosphorylation | YEALVPGSINYALEY EEEECCCCHHHHHHH | 25907765 | ||
| 1750 | Phosphorylation | LVPGSINYALEYHNR ECCCCHHHHHHHCCE | 25907765 | ||
| 1754 | Phosphorylation | SINYALEYHNRIYIC CHHHHHHHCCEEEEE | 25907765 | ||
| 1811 | Phosphorylation | LEQGIATSLIKAMNA HHHHHHHHHHHHHHH | 24719451 | ||
| 1838 | Phosphorylation | IRRSALLYIALHLKA HHHHHHHHHHHHHHH | 46161601 | ||
| 1858 | Phosphorylation | SEYTRKKYKKKMEQF CHHHHHHHHHHHHHH | 26074081 | ||
| 1868 | Phosphorylation | KMEQFMESCELITYL HHHHHHHHHHHHHHH | 26074081 | ||
| 1873 | Phosphorylation | MESCELITYLGAKMT HHHHHHHHHHHHHHH | 26074081 | ||
| 1874 | Phosphorylation | ESCELITYLGAKMTR HHHHHHHHHHHHHHH | 26074081 | ||
| 1880 | Phosphorylation | TYLGAKMTRKYKEPQ HHHHHHHHHCCCCCC | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KAD9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KAD9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KAD9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ENPL_HUMAN | HSP90B1 | physical | 26344197 | |
| RHOA_HUMAN | RHOA | physical | 28514442 | |
| LRC23_HUMAN | LRRC23 | physical | 28514442 | |
| EXOG_HUMAN | EXOG | physical | 28514442 | |
| CE034_HUMAN | C5orf34 | physical | 28514442 | |
| HDAC3_HUMAN | HDAC3 | physical | 28514442 | |
| TAF2_HUMAN | TAF2 | physical | 28514442 | |
| MYO9A_HUMAN | MYO9A | physical | 28514442 | |
| PRI1_HUMAN | PRIM1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
