DC122_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC122_HUMAN
• UniProt AC: Q5VW00
• Protein Name: DDB1- and CUL4-associated factor 12-like protein 2
• Gene Name: DCAF12L2
• Organism: Homo sapiens (Human).
• Sequence Length: 463
• Protein Sequence: MAQQQTGSRKRKAPAVEAGAGSSSSQGLAAADGEGPLLPKKQKRPATRRRLVHYLKGREVGARGPAGLQGFEGELRGYAVQRLPELLTERQLDLGTLNKVFASQWLNARQVVCGTKCNTLFVVDVQSGHITRIPLMRDKEAGLAQAHQGCGIHAIELNPSKTLLATGGENPNSLAIYQLPTLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVALWRMDPDMFNGSIAWHSEVGLPVYAHIRPRDVEAIPRASTNPSNRKVRALAFSGKNQELGAVSLDGYFHLWKARSTLSRLLSIRLPYCRENVCLTYCDELSLYAVGSQSHVSFLDPRQRQQNIRPLCSREGGTGVRSLSFYQHIITVGTGHGSLLFYDIRAQKFLEERASSSLDSMPGPAGRKLKLACGRGWLNQDDVWVNYFGGMGEFPNALYTHCYNWPEMKLFVAGGPLPSGLHGNYAGLWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAQQQTGSRKRKAPA CCCCCCCCCCCCCCC	37.71	-
23	Phosphorylation	VEAGAGSSSSQGLAA EECCCCCCCHHCCCC	32.84	-
25	Phosphorylation	AGAGSSSSQGLAAAD CCCCCCCHHCCCCCC	30.16	-
96	Phosphorylation	ERQLDLGTLNKVFAS HHCCCHHHHHHHHHH	34.16	23532336
103	Phosphorylation	TLNKVFASQWLNARQ HHHHHHHHHHHCCCE	15.49	24260401
257	Phosphorylation	VEAIPRASTNPSNRK CCCCCCCCCCCCCHH	29.96	23312004
258	Phosphorylation	EAIPRASTNPSNRKV CCCCCCCCCCCCHHE	50.60	23312004
261	Phosphorylation	PRASTNPSNRKVRAL CCCCCCCCCHHEEEE	51.87	23312004
281	Phosphorylation	NQELGAVSLDGYFHL CCCCCCEEECCHHHH	21.87	-
357	Phosphorylation	GTGVRSLSFYQHIIT CCCEEEEEEEEEEEE	24.13	24425749
367	Phosphorylation	QHIITVGTGHGSLLF EEEEEECCCCCEEEE	22.97	24425749

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC122_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC122_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC122_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DC121_HUMAN	DCAF12L1	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
CETN3_HUMAN	CETN3	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
CETN2_HUMAN	CETN2	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.