DC121_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC121_HUMAN
• UniProt AC: Q5VU92
• Protein Name: DDB1- and CUL4-associated factor 12-like protein 1
• Gene Name: DCAF12L1
• Organism: Homo sapiens (Human).
• Sequence Length: 463
• Protein Sequence: MAQQQTGSRKRKAPAVEADAESSPSQGLAAADGEGPLLLKRQRRPATYRSMAHYLKVREVGGWGPARLQGFDGELRGYAVQRLPELLTERQLELGTVNKVFASQWLNSRQVVCGTKCNTLFVVDVESGHIARIPLLRDSEARLAQDQQGCGIHAIELNPSKTLLATGGENPNSLAIYQLPSLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVALWRMDPDKFDDTVAWHSEVGLPVYAHIRPRDVEAIPRAIINPSNRKVRALACGGKNQELGAVSLDGYFHLWKAGSALSRLLSIRLPYFRDNVCLTYCDDMSVYAVGSHSHVSFLDLRQDQQNIRPLCSREGGTGVRSLSFYRHIITVGTGQGSLLFYDVRAQKFLEERASATLESSSGPARRKLRLACGRGWLNHNDFWVNYFGGMEVFPNALYTHCYNWPEMKLFVAGGPLPAGLHGNYAGLWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAQQQTGSRKRKAPA CCCCCCCCCCCCCCC	37.71	-
22	Phosphorylation	AVEADAESSPSQGLA CCCCCCCCCCCCCCC	49.63	30266825
23	Phosphorylation	VEADAESSPSQGLAA CCCCCCCCCCCCCCC	21.78	30266825
25	Phosphorylation	ADAESSPSQGLAAAD CCCCCCCCCCCCCCC	38.54	30266825
261	Phosphorylation	PRAIINPSNRKVRAL CCEEECCCCCEEEEE	44.79	-
281	Phosphorylation	NQELGAVSLDGYFHL CCCCCCEEECCCHHH	21.87	-
388	Phosphorylation	KFLEERASATLESSS HHHHHHHHCHHHCCC	28.18	27174698
390	Phosphorylation	LEERASATLESSSGP HHHHHHCHHHCCCCH	28.67	27174698
393	Phosphorylation	RASATLESSSGPARR HHHCHHHCCCCHHHH	32.68	27174698
394	Phosphorylation	ASATLESSSGPARRK HHCHHHCCCCHHHHH	29.91	27174698
395	Phosphorylation	SATLESSSGPARRKL HCHHHCCCCHHHHHH	59.06	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC121_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC121_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC121_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH22A_HUMAN	SH2D2A	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.