dbPTM

DCST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCST1_HUMAN
UniProt AC	Q5T197
Protein Name	E3 ubiquitin-protein ligase DCST1 {ECO:0000305}
Gene Name	DCST1
Organism	Homo sapiens (Human).
Sequence Length	706
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling..
Protein Sequence	MDIKHHQNGTRGQRRKQPHTTVQRLLTWGLPVSCSWFLWRQPGEFPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMGWGTSPHIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRAAWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGETAQGREARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMKHIWVPLLTHLLCLPMKFKFFCGIAKVMEVWCRNRIPVEGNFGQTYDSLNQSIRGLDGEFSANIDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSNVVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYWRAAVPIGLLVCLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Acetylation	GTRGQRRKQPHTTVQ CCCCCCCCCCCCHHH	71.07	19814963
156	N-linked_Glycosylation	CTVELQINNTRAAWR CEEEEEECCCCHHHE	30.75	UniProtKB CARBOHYD
189	N-linked_Glycosylation	LLRAETRNISATFED HHHHHHHCCCCCHHH	39.73	UniProtKB CARBOHYD
236	Phosphorylation	ASRLHLSTQKMYELK HHHHCCCHHHHHHHH	38.27	30576142
321	N-linked_Glycosylation	GQTYDSLNQSIRGLD CCCHHHHHHHHHCCC	37.19	UniProtKB CARBOHYD
349	N-linked_Glycosylation	QAGVLGLNTSWERVS HHCCCCCCCCHHHHH	30.21	UniProtKB CARBOHYD
439	Phosphorylation	LRKAEEKTVIFPCKP CCCCCCCEEEEECCC	23.32	-
511	Phosphorylation	EVKVGGDSMLARLLR EEEECCHHHHHHHHH	20.97	-
525	N-linked_Glycosylation	RKTIGALNTSSETVM HHHHCCCCCCCCCHH	37.06	UniProtKB CARBOHYD
601	Acetylation	LYNDLLKKRAAFTKL HHHHHHHHHHHHHHH	47.44	7480015
669	Phosphorylation	TLDCEAVYCWSCWDD EECCCEEEEECHHHH	8.68	23403867
672	Phosphorylation	CEAVYCWSCWDDMRQ CCEEEEECHHHHHHH	11.19	23403867
685	Phosphorylation	RQRCPVCTPREELSS HHHCCCCCCHHHHCC	26.14	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCST1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCST1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DCST1_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCST1_HUMAN

Related Literatures of Post-Translational Modification