ARSI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARSI_HUMAN
• UniProt AC: Q5FYB1
• Protein Name: Arylsulfatase I
• Gene Name: ARSI
• Organism: Homo sapiens (Human).
• Sequence Length: 569
• Subcellular Localization: Secreted . Endoplasmic reticulum . Localized in the intracellular granular structures.
• Protein Description: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts..
• Protein Sequence: MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	3-oxoalanine (Cys)	NYYIQPICTPSRSQL EEEECCCCCCCHHHH	6.11	-
93	Oxidation	NYYIQPICTPSRSQL EEEECCCCCCCHHHH	6.11	19262745
114	Phosphorylation	IHTGLQHSIIRPQQP ECCCCCCCCCCCCCC	13.52	24719451
252	Phosphorylation	PREYLYRYRTMGNVA HHHHHHHHHHHHHHH	9.25	-
263	Phosphorylation	GNVARRKYAAMVTCM HHHHHHHHHHHHHHH	9.59	-
276	N-linked_Glycosylation	CMDEAVRNITWALKR HHHHHHHHHHHHHHH	29.46	UniProtKB CARBOHYD
288	N-linked_Glycosylation	LKRYGFYNNSVIIFS HHHHCCCCCEEEEEE	31.85	UniProtKB CARBOHYD
302	Phosphorylation	SSDNGGQTFSGGSNW ECCCCCCEECCCCCC	24.04	-
304	Phosphorylation	DNGGQTFSGGSNWPL CCCCCEECCCCCCCC	45.70	-
307	Phosphorylation	GQTFSGGSNWPLRGR CCEECCCCCCCCCCC	38.97	-
331	Phosphorylation	RGLGFVHSPLLKRKQ CCCCCCCCHHHHCHH	16.37	24719451
457	Phosphorylation	WNLERMASVRQAVWL CCHHHHHHHHHHHHH	14.43	24719451
466	N-linked_Glycosylation	RQAVWLFNISADPYE HHHHHHEECCCCCCC	25.74	UniProtKB CARBOHYD
496	N-linked_Glycosylation	LARLAEYNRTAIPVR HHHHHHHCCCCCCCC	26.74	UniProtKB CARBOHYD
540	Phosphorylation	EGRARSFSRGRRKKK HHHCCCCCCCCCCCC	34.76	17081983
555	Phosphorylation	CKICKLRSFFRKLNT CCHHHHHHHHHHHHH	38.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARSI_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
93	C	Oxidation	The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.	19262745
93	C	Sulfation	The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.	19262745

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARSI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOL11_HUMAN	NOL11	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.