CC116_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC116_HUMAN
• UniProt AC: Q8IYX3
• Protein Name: Coiled-coil domain-containing protein 116
• Gene Name: CCDC116
• Organism: Homo sapiens (Human).
• Sequence Length: 515
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Sequence: MARCRHHSGYLADDEASHSMCSARVQLPKKPLVPEMRPACKPGRVPHPPSTCGSSALQGQRRNKRHPQPFGHFLDFLTESQVLDSLETVVEKATERMAAMKTEAGVPLVEVQDPVEVPSGGRRAHARPSLSTVHRHRVRPTLCTGHPNNYPSSSSSMSNCHSSLMAGCLGSHSRDSDLGAQGSLPPVRDKLLLEKNLKRLLQLEREGKGLSQSCSQRDSLLWDSLGSQTSFQWTQEQPLSWFSGLLGSSSGVPEASEPRPGEQEPIFRKREFNKEIKSLLSQLESLDLPGYCPLREPHRTLNFLADHRLFPALQSVVSQAVDKLRGAHCRDGRPLFPTSLEPTSDLPPLGSEPAKPTNGGQPYASPRPTVSSPKMLQRKRKDRGGSPSMSSAQVATRFKLKSPCSSSRFTKKKPLPSISSKSSMSHFSNRLYEELADFLTQQAASLVIRKYEFEKDLSKQLGFFSFPITHVLRDLSLGLKKVKGSRIHLSSETHRSCLLRKLEESKRAAAVSLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
119	Phosphorylation	QDPVEVPSGGRRAHA CCCEECCCCCCCCCC	60.08	30622161
213	O-linked_Glycosylation	EGKGLSQSCSQRDSL HCCCCCHHHHHHHHH	16.62	29351928
278	Phosphorylation	EFNKEIKSLLSQLES HHHHHHHHHHHHHHH	39.96	-
281	Phosphorylation	KEIKSLLSQLESLDL HHHHHHHHHHHHCCC	37.70	-
285	Phosphorylation	SLLSQLESLDLPGYC HHHHHHHHCCCCCCC	35.46	-
291	Phosphorylation	ESLDLPGYCPLREPH HHCCCCCCCCCCCCC	6.75	-
386	Phosphorylation	KRKDRGGSPSMSSAQ HHCCCCCCCCCCHHH	19.34	29083192
388	Phosphorylation	KDRGGSPSMSSAQVA CCCCCCCCCCHHHHH	32.75	30622161
390	Phosphorylation	RGGSPSMSSAQVATR CCCCCCCCHHHHHHH	27.19	29083192
391	Phosphorylation	GGSPSMSSAQVATRF CCCCCCCHHHHHHHH	17.68	30622161
396	Phosphorylation	MSSAQVATRFKLKSP CCHHHHHHHHCCCCC	37.47	30622161
397	Dimethylation	SSAQVATRFKLKSPC CHHHHHHHHCCCCCC	19.57	-
402	Phosphorylation	ATRFKLKSPCSSSRF HHHHCCCCCCCCCCC	41.39	30622161
405	Phosphorylation	FKLKSPCSSSRFTKK HCCCCCCCCCCCCCC	34.43	30622161
406	Phosphorylation	KLKSPCSSSRFTKKK CCCCCCCCCCCCCCC	32.05	30622161
407	Phosphorylation	LKSPCSSSRFTKKKP CCCCCCCCCCCCCCC	18.34	30622161
410	Phosphorylation	PCSSSRFTKKKPLPS CCCCCCCCCCCCCCC	40.62	30622161
417	Phosphorylation	TKKKPLPSISSKSSM CCCCCCCCCCCCHHH	42.67	25627689
419	Phosphorylation	KKPLPSISSKSSMSH CCCCCCCCCCHHHHH	35.73	25627689
465	Phosphorylation	SKQLGFFSFPITHVL HHHHCCCCCHHHHHH	28.05	22210691
469	Phosphorylation	GFFSFPITHVLRDLS CCCCCHHHHHHHHHH	13.23	22210691
545 (in isoform 2)	Phosphorylation	-		30631047
547 (in isoform 2)	Phosphorylation	-		25693802
548 (in isoform 2)	Phosphorylation	-		30622161
553 (in isoform 2)	Phosphorylation	-		30622161
557 (in isoform 2)	Phosphorylation	-		30622161
564 (in isoform 2)	Phosphorylation	-		25693802
566 (in isoform 2)	Phosphorylation	-		25693802
569 (in isoform 2)	Phosphorylation	-		25262027
573 (in isoform 2)	Phosphorylation	-		25262027
574 (in isoform 2)	Phosphorylation	-		25262027

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC116_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC116_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC116_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM9B_HUMAN	FAM9B	physical	25416956
MTUS2_HUMAN	MTUS2	physical	21516116
BEX3_HUMAN	NGFRAP1	physical	21516116
TRAF1_HUMAN	TRAF1	physical	21516116
CEP44_HUMAN	CEP44	physical	21516116
PAPS1_HUMAN	PAPSS1	physical	28514442
GNL1_HUMAN	GNL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.