ZN557_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN557_HUMAN
• UniProt AC: Q8N988
• Protein Name: Zinc finger protein 557
• Gene Name: ZNF557
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAAVVLPPTAASQREGHTEGGELVNELLKSWLKGLVTFEDVAVEFTQEEWALLDPAQRTLYRDVMLENCRNLASLGNQVDKPRLISQLEQEDKVMTEERGILSGTCPDVENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKVFSTKSSLTRHRKIHTGERPYGCSECGKSYSSRSYLAVHKRIHNGEKPYECNDCGKTFSSRSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCFREFRTQSIFTRHKRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSNLTQHIRTHTGEKPYTCNECGKSFTNSFSLTIHRRIHNGEKSYECSDCGKSFNVLSSVKKHMRTHTGKKPYECNYCGKSFTSNSYLSVHTRMHNRQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Ubiquitination	SLGNQVDKPRLISQL HHCCCCCHHHHHHHH	32.93	29967540
88	Ubiquitination	KPRLISQLEQEDKVM HHHHHHHHHHHCHHH	6.15	29967540
143	Phosphorylation	ERNHLGATLNECNQC HHHHHHHHHHHHHHH	28.46	-
168	Phosphorylation	TRHRKIHTGERPYGC CCCCCCCCCCCCCCC	44.18	28555341
209	Phosphorylation	ECNDCGKTFSSRSYL ECCCCCCCCCCCCEE	17.65	-
252	Phosphorylation	RPHLRIHTGEKPYKC CCEEEEECCCCCCCC	44.67	29496963
255	Ubiquitination	LRIHTGEKPYKCNQC EEEECCCCCCCCCHH	55.80	22505724
262	Ubiquitination	KPYKCNQCFREFRTQ CCCCCCHHHHHHHHH	1.85	22505724
326	Phosphorylation	GRTFRRRSNLTQHIR CCCEECCCCCHHHHH	34.09	28555341
334	Phosphorylation	NLTQHIRTHTGEKPY CCHHHHHHCCCCCCE	24.16	-
336	Phosphorylation	TQHIRTHTGEKPYTC HHHHHHCCCCCCEEC	46.56	-
382	Phosphorylation	GKSFNVLSSVKKHMR CCCHHHHHHHHHHHH	28.89	28555341
383	Phosphorylation	KSFNVLSSVKKHMRT CCHHHHHHHHHHHHH	33.52	28555341
397	Phosphorylation	THTGKKPYECNYCGK HCCCCCCEECCCCCC	41.83	-
405	Phosphorylation	ECNYCGKSFTSNSYL ECCCCCCCCCCCCCE	21.02	-
413	Phosphorylation	FTSNSYLSVHTRMHN CCCCCCEEEHHCCCC	12.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN557_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN557_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN557_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM6_HUMAN	PRMT6	physical	23455924
SMYD3_HUMAN	SMYD3	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
SUV92_HUMAN	SUV39H2	physical	23455924
NSD3_HUMAN	WHSC1L1	physical	23455924
CEP70_HUMAN	CEP70	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.