PAP1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAP1L_HUMAN
• UniProt AC: Q4VXU2
• Protein Name: Polyadenylate-binding protein 1-like
• Gene Name: PABPC1L
• Organism: Homo sapiens (Human).
• Sequence Length: 614
• Protein Sequence: MNASGSGYPLASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEMLKGQPIRIMWSQRDPGLRKSGVGNIFIKNLEDSIDNKALYDTFSTFGNILSCKVACDEHGSRGFGFVHFETHEAAQQAINTMNGMLLNDRKVFVGHFKSRREREAELGARALEFTNIYVKNLPVDVDEQGLQDLFSQFGKMLSVKVMRDNSGHSRCFGFVNFEKHEEAQKAVVHMNGKEVSGRLLYAGRAQKRVERQNELKRRFEQMKQDRLRRYQGVNLYVKNLDDSIDDDKLRKEFSPYGVITSAKVMTEGGHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYMQRLSTMRTLSNPLLGSFQQPSSYFLPAMPQPPAQAAYYGCGPVTPTQPAPRWTSQPPRPSCASMVRPPVVPRRPPAHISSVRQASTQVPRTVPHTQRVANIGTQTTGPSGVGCCTPGRPLLPCKCSSAAHSTYRVQEPAVHIPGQEPLTASMLAAAPLHEQKQMIGERLYPLIHDVHTQLAGKITGMLLEIDNSELLLMLESPESLHAKIDEAVAVLQAHQAMEQPKAYMH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNASGSGY -------CCCCCCCC	9.49	-
28	Phosphorylation	DVTEAMLYEKFSPAG CCHHHHHHHHCCCCC	12.18	26503514
32	Phosphorylation	AMLYEKFSPAGPILS HHHHHHCCCCCCEEE	25.55	21815630
39	Phosphorylation	SPAGPILSIRVCRDV CCCCCEEEEEEECCH	14.74	21406692
71	Phosphorylation	DAERALDTMNFEMLK HHHHHHHHCCHHHHC	18.18	20860994
87	Phosphorylation	QPIRIMWSQRDPGLR CCEEEEEECCCCCCC	9.65	-
95	Ubiquitination	QRDPGLRKSGVGNIF CCCCCCCCCCCCCEE	57.51	21906983
96	Phosphorylation	RDPGLRKSGVGNIFI CCCCCCCCCCCCEEE	32.07	30266825
166	Methylation	NGMLLNDRKVFVGHF CCCCCCCCEEEECCC	35.64	-
219	Phosphorylation	SQFGKMLSVKVMRDN HHHCCCEEEEEEECC	19.18	24719451
284	Ubiquitination	KRRFEQMKQDRLRRY HHHHHHHHHHHHHHH	49.06	21906983
291	Phosphorylation	KQDRLRRYQGVNLYV HHHHHHHHHCCCEEE	11.81	28152594
297	Phosphorylation	RYQGVNLYVKNLDDS HHHCCCEEECCCCCC	12.27	28152594
299	Methylation	QGVNLYVKNLDDSID HCCCEEECCCCCCCC	37.93	-
315	Phosphorylation	DKLRKEFSPYGVITS HHHHHHCCCCCEEEE	20.50	-
333	Ubiquitination	MTEGGHSKGFGFVCF EECCCCCCCCEEEEE	53.21	21890473
339	S-nitrosylation	SKGFGFVCFSSPEEA CCCCEEEEECCHHHH	2.27	19483679
339	S-palmitoylation	SKGFGFVCFSSPEEA CCCCEEEEECCHHHH	2.27	29575903
339	S-nitrosocysteine	SKGFGFVCFSSPEEA CCCCEEEEECCHHHH	2.27	-
341	Phosphorylation	GFGFVCFSSPEEATK CCEEEEECCHHHHHH	39.60	25159151
342	Phosphorylation	FGFVCFSSPEEATKA CEEEEECCHHHHHHH	18.97	25159151
347	Phosphorylation	FSSPEEATKAVTEMN ECCHHHHHHHHHHHC	23.86	24732914
348	Ubiquitination	SSPEEATKAVTEMNG CCHHHHHHHHHHHCC	48.16	21906983
364	Phosphorylation	IVGTKPLYVALAQRK ECCCHHHHHHHHHCH	7.69	25159151
385	Methylation	LTNQYMQRLSTMRTL HHHHHHHHHHHHHHH	17.67	-
434	Methylation	TPTQPAPRWTSQPPR CCCCCCCCCCCCCCC	51.95	-
462	Phosphorylation	RRPPAHISSVRQAST CCCCCCHHHHHHHCC	16.95	24719451
468	Phosphorylation	ISSVRQASTQVPRTV HHHHHHHCCCCCCCC	15.84	25599653
469	Phosphorylation	SSVRQASTQVPRTVP HHHHHHCCCCCCCCC	36.28	23532336
473	Methylation	QASTQVPRTVPHTQR HHCCCCCCCCCCCCE	49.88	-
480	Methylation	RTVPHTQRVANIGTQ CCCCCCCEEEEECCC	30.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAP1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAP1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAP1L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PAP1L_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.