dbPTM

AMY2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AMY2B_HUMAN
UniProt AC	P19961
Protein Name	Alpha-amylase 2B
Gene Name	AMY2B
Organism	Homo sapiens (Human).
Sequence Length	511
Subcellular Localization	Secreted.
Protein Description
Protein Sequence	MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMSGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Pyrrolidone_carboxylic_acid	TIGFCWAQYSPNTQQ HHHHHHHHCCCCCCC	18.10	-
16	Pyrrolidone_carboxylic_acid	TIGFCWAQYSPNTQQ HHHHHHHHCCCCCCC	18.10	-
77	Phosphorylation	FRPWWERYQPVSYKL CCCHHHHHCCCEEEE	12.97	22461510
81	Phosphorylation	WERYQPVSYKLCTRS HHHHCCCEEEEECCC	24.19	59303295
82	Phosphorylation	ERYQPVSYKLCTRSG HHHCCCEEEEECCCC	14.28	22461510
166	Phosphorylation	GSGDIENYNDATQVR CCCCCCCCCCCCCHH	11.13	-
189	Phosphorylation	DLALEKDYVRSKIAE HHHHCHHHHHHHHHH	14.61	6878329
197	Phosphorylation	VRSKIAEYMNHLIDI HHHHHHHHHHHHHHH	8.32	7095097
273	Phosphorylation	GRVTEFKYGAKLGTV CCEEEEECCCCHHCE	27.86	-
326	Phosphorylation	GHGAGGASILTFWDA CCCCCCCHHHHHHHH	22.77	21299198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AMY2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AMY2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AMY2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AMY2B_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AMY2B_HUMAN

Related Literatures of Post-Translational Modification