VGF_HUMAN - dbPTM
VGF_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VGF_HUMAN
UniProt AC O15240
Protein Name Neurosecretory protein VGF
Gene Name VGF
Organism Homo sapiens (Human).
Sequence Length 615
Subcellular Localization Secreted . Cytoplasmic vesicle, secretory vesicle . Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
Protein Description May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.; NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.; Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris..
Protein Sequence MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationEAQPPPLSSEHKEPV
CCCCCCCCCCCCCCC		39.1824505115
37PhosphorylationAQPPPLSSEHKEPVA
CCCCCCCCCCCCCCC		51.9424505115
65PhosphorylationEVRGARNSEPQDEGE
CCCCCCCCCCCCCCC		45.1324505115
95O-linked_GlycosylationQALDRPASPPAPSGS
HHHCCCCCCCCCCCC		33.81OGP
95PhosphorylationQALDRPASPPAPSGS
HHHCCCCCCCCCCCC		33.8127732954
100PhosphorylationPASPPAPSGSQQGPE
CCCCCCCCCCCCCCH		53.8627732954
102PhosphorylationSPPAPSGSQQGPEEE
CCCCCCCCCCCCHHH		24.5427732954
131PhosphorylationHSLPAPESPEPAAPP
CCCCCCCCCCCCCCC		33.2425921289
142PhosphorylationAAPPRPQTPENGPEA
CCCCCCCCCCCCCCC		34.9425921289
170PhosphorylationLQELRDFSPSSAKRQ
HHHHHHCCHHHHHHH		28.3226437602
180O-linked_GlycosylationSAKRQQETAAAETET
HHHHHHHHHHHHCHH		19.7755830199
180PhosphorylationSAKRQQETAAAETET
HHHHHHHHHHHHCHH		19.7725022875
185PhosphorylationQETAAAETETRTHTL
HHHHHHHCHHCCEEE		37.6225022875
187PhosphorylationTAAAETETRTHTLTR
HHHHHCHHCCEEEEE		48.5725022875
187O-linked_GlycosylationTAAAETETRTHTLTR
HHHHHCHHCCEEEEE		48.5755830201
189O-linked_GlycosylationAAETETRTHTLTRVN
HHHCHHCCEEEEEEE		26.9955830203
189PhosphorylationAAETETRTHTLTRVN
HHHCHHCCEEEEEEE		26.9925022875
191PhosphorylationETETRTHTLTRVNLE
HCHHCCEEEEEEECC		29.2525022875
191O-linked_GlycosylationETETRTHTLTRVNLE
HCHHCCEEEEEEECC		29.2555830205
193PhosphorylationETRTHTLTRVNLESP
HHCCEEEEEEECCCC		33.4525022875
193O-linked_GlycosylationETRTHTLTRVNLESP
HHCCEEEEEEECCCC		33.4555830207
199PhosphorylationLTRVNLESPGPERVW
EEEEECCCCCCHHHH		38.0225262027
209O-linked_GlycosylationPERVWRASWGEFQAR
CHHHHEECCCCCCCC		27.34OGP
209PhosphorylationPERVWRASWGEFQAR
CHHHHEECCCCCCCC		27.3427499020
229O-linked_GlycosylationPLPPPAPSQFQARMP
CCCCCCCHHHHCCCC		45.81OGP
238PhosphorylationFQARMPDSGPLPETH
HHCCCCCCCCCCCCC		36.1227732954
244PhosphorylationDSGPLPETHKFGEGV
CCCCCCCCCCCCCCC		28.5525850435
246UbiquitinationGPLPETHKFGEGVSS
CCCCCCCCCCCCCCC		63.5823503661
252O-linked_GlycosylationHKFGEGVSSPKTHLG
CCCCCCCCCCCCHHH		52.3555834007
253O-linked_GlycosylationKFGEGVSSPKTHLGE
CCCCCCCCCCCHHHH		28.1955834009
255UbiquitinationGEGVSSPKTHLGEAL
CCCCCCCCCHHHHHH		50.9923503661
256O-linked_GlycosylationEGVSSPKTHLGEALA
CCCCCCCCHHHHHHH		26.2255834083
266O-linked_GlycosylationGEALAPLSKAYQGVA
HHHHHHHHHHHCCCC		17.7455834085
267UbiquitinationEALAPLSKAYQGVAA
HHHHHHHHHHCCCCC		59.8123503661
278UbiquitinationGVAAPFPKARRPESA
CCCCCCCCCCCCHHH		55.7123503661
284PhosphorylationPKARRPESALLGGSE
CCCCCCHHHHCCCCH		27.2227732954
290PhosphorylationESALLGGSEAGERLL
HHHHCCCCHHHHHHH		23.6027732954
310Pyrrolidone_carboxylic_acidQVEAGRRQAEATRQA
HHHHHHHHHHHHHHH		42.0419194657
310Pyrrolidone_carboxylic_acidQVEAGRRQAEATRQA
HHHHHHHHHHHHHHH		42.0419194657
310Pyrrolidone_carboxylic_acidQVEAGRRQAEATRQA
HHHHHHHHHHHHHHH		42.04-
314PhosphorylationGRRQAEATRQAAAQE
HHHHHHHHHHHHHHH		18.1527067055
360PhosphorylationEAAEERESAREEEEA
HHHHHHHHHHHHHHH		38.5624505115
418UbiquitinationGEAGAEDKRSQEETP
CCCCCCCCCCCCCCC		45.5123503661
420PhosphorylationAGAEDKRSQEETPGH
CCCCCCCCCCCCCCC		47.9229255136
424PhosphorylationDKRSQEETPGHRRKE
CCCCCCCCCCCCCHH		33.5428985074
471PhosphorylationLPADDVVSIIEEVEE
CCHHHHHHHHHHHHH		20.0727732954
479UbiquitinationIIEEVEEKRKRKKNA
HHHHHHHHHHHHCCC		50.1123503661
481UbiquitinationEEVEEKRKRKKNAPP
HHHHHHHHHHCCCCC		78.5823503661
483UbiquitinationVEEKRKRKKNAPPEP
HHHHHHHHCCCCCCC		54.1123503661
484UbiquitinationEEKRKRKKNAPPEPV
HHHHHHHCCCCCCCC		63.4823503661
554O-linked_GlycosylationPNYIRPRTLQPPSAL
CCCCCCCCCCCCCHH		32.2155832395
577Proline amideLPPSRHYPGREAQAR
CCCCCCCCCHHHHHH		29.28-
577AmidationLPPSRHYPGREAQAR
CCCCCCCCCHHHHHH		29.2823250050
606PhosphorylationEQEELENYIEHVLLR
HHHHHHHHHHHHHHC		9.7927642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
420SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
424TPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VGF_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VGF_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VGF_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VGF_HUMAN

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Related Literatures of Post-Translational Modification

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