MSD2_HUMAN - dbPTM
MSD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSD2_HUMAN
UniProt AC Q6P1R3
Protein Name Myb/SANT-like DNA-binding domain-containing protein 2
Gene Name MSANTD2
Organism Homo sapiens (Human).
Sequence Length 559
Subcellular Localization
Protein Description
Protein Sequence MAAPCGSELPANSPLKIPKMEVLSPASPGGLSDGNPSLSDPSTPRGASPLGPGSAAGSGAAASGGLGLGLGGRSAASSSVSFSPGGGGGGAAAAAAAACRGMSWTPAETNALIAVWGNERLVEARYQQLEGAGTVFGSKAPGPAMYERVSRALAELGYERTPSQCRERIKTLRRCYSRVKEHGVGKRKSSYTFEQLEQVFGQGGWDAQPCQPVLINSSGLYQELESDGSTMEDYSQEDWGNHSQDLHGYPTDQELDEIPVTKRTLKIKQESSEEAQKRDIMQNIVQILESVQLKWELFQSWTDFSRLHLSNKLAIFGIGYNTRWKEDIRYHYAEISSQVPLGKRLREYFNSEKPEGRIIMTRVQKMNWKNVYYKFLEITISEARCLELHMEIDWIPIAHSKPTGGNVVQYLLPGGIPKSPGLYAIGYEECIERPLSPHMEQSSLDPGKEGRVDLETLSAQASLQVEIEPTRIIYCYLGIAEVRTLQQCLFLHFQANTKTFSKDWVGINGFLSQNCIVDPGVSPKSIYIKFVEVERDFLSAGSLVECLEKAIGYPLKFNN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAAPCGSELPANSP
-CCCCCCCCCCCCCC		42.5529255136
13PhosphorylationGSELPANSPLKIPKM
CCCCCCCCCCCCCCE		33.4429255136
24PhosphorylationIPKMEVLSPASPGGL
CCCEEEECCCCCCCC		24.4829255136
27PhosphorylationMEVLSPASPGGLSDG
EEEECCCCCCCCCCC		27.7129255136
32PhosphorylationPASPGGLSDGNPSLS
CCCCCCCCCCCCCCC		46.9029255136
37PhosphorylationGLSDGNPSLSDPSTP
CCCCCCCCCCCCCCC		44.5028450419
39PhosphorylationSDGNPSLSDPSTPRG
CCCCCCCCCCCCCCC		52.3828450419
42PhosphorylationNPSLSDPSTPRGASP
CCCCCCCCCCCCCCC		56.9128450419
43PhosphorylationPSLSDPSTPRGASPL
CCCCCCCCCCCCCCC		23.5328450419
48PhosphorylationPSTPRGASPLGPGSA
CCCCCCCCCCCCCCC		24.3929255136
54PhosphorylationASPLGPGSAAGSGAA
CCCCCCCCCCCCCCH		20.3423927012
58PhosphorylationGPGSAAGSGAAASGG
CCCCCCCCCCHHCCC		22.1130278072
63PhosphorylationAGSGAAASGGLGLGL
CCCCCHHCCCCCCCC		28.7723403867
74PhosphorylationGLGLGGRSAASSSVS
CCCCCCCCCCCCEEE		31.3126552605
77PhosphorylationLGGRSAASSSVSFSP
CCCCCCCCCEEEECC		23.9026552605
78PhosphorylationGGRSAASSSVSFSPG
CCCCCCCCEEEECCC		29.9926552605
79PhosphorylationGRSAASSSVSFSPGG
CCCCCCCEEEECCCC		21.2026552605
81PhosphorylationSAASSSVSFSPGGGG
CCCCCEEEECCCCCC		23.1926552605
83PhosphorylationASSSVSFSPGGGGGG
CCCEEEECCCCCCHH		18.3528985074
161PhosphorylationAELGYERTPSQCRER
HHCCCCCCHHHHHHH		18.4928555341
268SumoylationTKRTLKIKQESSEEA
CCCEEEECCCCCHHH		46.5628112733
268UbiquitinationTKRTLKIKQESSEEA
CCCEEEECCCCCHHH		46.56-
268SumoylationTKRTLKIKQESSEEA
CCCEEEECCCCCHHH		46.56-
300PhosphorylationLKWELFQSWTDFSRL
HHHHHHHCCCHHHHH		25.3027174698
302PhosphorylationWELFQSWTDFSRLHL
HHHHHCCCHHHHHHH		32.2027174698
305PhosphorylationFQSWTDFSRLHLSNK
HHCCCHHHHHHHCCC		36.4227174698
323MethylationFGIGYNTRWKEDIRY
EEECCCCCCHHHHHH		38.54115483855
325UbiquitinationIGYNTRWKEDIRYHY
ECCCCCCHHHHHHHH		42.07-
330PhosphorylationRWKEDIRYHYAEISS
CCHHHHHHHHHHHHC		10.2628270605
332PhosphorylationKEDIRYHYAEISSQV
HHHHHHHHHHHHCCC		9.3028270605
336PhosphorylationRYHYAEISSQVPLGK
HHHHHHHHCCCCHHH		13.2628270605
337PhosphorylationYHYAEISSQVPLGKR
HHHHHHHCCCCHHHH		40.6428270605
343SumoylationSSQVPLGKRLREYFN
HCCCCHHHHHHHHHC		56.8128112733
348PhosphorylationLGKRLREYFNSEKPE
HHHHHHHHHCCCCCC		11.13-
384PhosphorylationEITISEARCLELHME
EEEECHHHHHHHCEE		22.8527251275
419PhosphorylationLPGGIPKSPGLYAIG
ECCCCCCCCCEEEEC		20.8826434776
423PhosphorylationIPKSPGLYAIGYEEC
CCCCCCEEEECHHHH		11.3326434776
427PhosphorylationPGLYAIGYEECIERP
CCEEEECHHHHHCCC		11.4825159151
436PhosphorylationECIERPLSPHMEQSS
HHHCCCCCCCCCHHC		18.5525159151
442PhosphorylationLSPHMEQSSLDPGKE
CCCCCCHHCCCCCCC		21.4029978859
443PhosphorylationSPHMEQSSLDPGKEG
CCCCCHHCCCCCCCC		36.1629978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERCC3_HUMANERCC3physical
21988832
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSD2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND SER-54, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.

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