ZN133_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN133_HUMAN
• UniProt AC: P52736
• Protein Name: Zinc finger protein 133
• Gene Name: ZNF133
• Organism: Homo sapiens (Human).
• Sequence Length: 654
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation as a repressor..
• Protein Sequence: MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	QDEWRLLSPAQRTLY HHHHHHCCHHHHHHH	23.84	23312004
34	Phosphorylation	REVMLENYSNLVSLG HHHHHHCHHCHHHHC	6.91	-
43	Phosphorylation	NLVSLGISFSKPELI CHHHHCCCCCCHHHH	22.97	24719451
201	Acetylation	GNPEETDKLLKRIEV CCHHHHHHHHHHEEE	64.24	10702417
222	Phosphorylation	NCGECGLSFSKMTNL CCCCCCCCHHHHHHH	16.86	24719451
268	Sumoylation	QKAHSGEKPIVCREC HHHHCCCCCEEEEEC	43.50	-
268	Sumoylation	QKAHSGEKPIVCREC HHHHCCCCCEEEEEC	43.50	-
310	Sumoylation	CGRGFSQKSNLIIHQ CCCCCCCCCCEEEEE	39.86	28112733
324	Sumoylation	QRTHSGEKPYVCREC ECCCCCCCCEEECCC	45.21	-
324	Sumoylation	QRTHSGEKPYVCREC ECCCCCCCCEEECCC	45.21	-
338	Sumoylation	CGKGFSQKSAVVRHQ CCCCCCHHHHHHHHC	38.90	28112733
367	Phosphorylation	GLGFSDRSNLISHQR CCCCCCCCCCCCCCC	40.76	29978859
371	Phosphorylation	SDRSNLISHQRTHSG CCCCCCCCCCCCCCC	19.41	29978859
375	Phosphorylation	NLISHQRTHSGEKPY CCCCCCCCCCCCCCC	17.52	29978859
377	Phosphorylation	ISHQRTHSGEKPYAC CCCCCCCCCCCCCCH	48.29	29978859
424	Phosphorylation	HSFSQNSTLISHRRT CCCCCCCCEEECCCC	35.34	-
427	Phosphorylation	SQNSTLISHRRTHTG CCCCCEEECCCCCCC	17.66	-
431	Phosphorylation	TLISHRRTHTGEKPY CEEECCCCCCCCCCE	24.60	-
433	Phosphorylation	ISHRRTHTGEKPYVC EECCCCCCCCCCEEE	46.56	-
461	Phosphorylation	NRHQNIHSGEKPIVC HCCCCCCCCCCCEEE	44.87	28555341
506	Sumoylation	CGRGFSQKSNLVAHQ CCCCCCHHCCCEEEE	39.86	-
506	Sumoylation	CGRGFSQKSNLVAHQ CCCCCCHHCCCEEEE	39.86	28112733
516	Phosphorylation	LVAHQRTHSGERPYV CEEEECCCCCCCCEE	35.67	24719451
517	Phosphorylation	VAHQRTHSGERPYVC EEEECCCCCCCCEEC	41.56	24719451
541	Methylation	QAGLIRHKRKHSREK HHHHHHCCCCCCCCC	53.98	-
576	Sumoylation	KRAHSEEKPCVCREC CCCCCCCCCEEECCC	39.40	28112733
601	Phosphorylation	TLHQMTHTGEKPYVC EEEECCCCCCCCEEE	37.56	-
604	Sumoylation	QMTHTGEKPYVCKTC ECCCCCCCCEEECCC	42.89	28112733
604	Sumoylation	QMTHTGEKPYVCKTC ECCCCCCCCEEECCC	42.89	-
606	Phosphorylation	THTGEKPYVCKTCGR CCCCCCCEEECCCCC	29.55	22817900
618	Sumoylation	CGRGFSLKSHLSRHR CCCCEEHHHHHHHCC	34.33	28112733
618	Sumoylation	CGRGFSLKSHLSRHR CCCCEEHHHHHHHCC	34.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN133_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN133_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN133_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	8769649
KR107_HUMAN	KRTAP10-7	physical	25416956
MRS2_HUMAN	MRS2	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
STK3_HUMAN	STK3	physical	28514442
TIF1A_HUMAN	TRIM24	physical	28514442
RT07_HUMAN	MRPS7	physical	28514442
STK4_HUMAN	STK4	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
RT02_HUMAN	MRPS2	physical	28514442
FRIL_HUMAN	FTL	physical	28514442
RT23_HUMAN	MRPS23	physical	28514442
TPD52_HUMAN	TPD52	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.