OGDHL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OGDHL_HUMAN
• UniProt AC: Q9ULD0
• Protein Name: 2-oxoglutarate dehydrogenase-like, mitochondrial
• Gene Name: OGDHL
• Organism: Homo sapiens (Human).
• Sequence Length: 1010
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MSQLRLLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWLENPQSVHKSWDSFFREASEEAFSGSAQPRPPSVVHESRSAVSSRTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDMLTHIGSVASSVPLEDFKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTAFNLQAFEGKTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SQLRLLPSRLGVQAA CCHHCCHHHHHHHHH	39.86	25278378
44	Acetylation	PATFPSSKGGGGSSY CCCCCCCCCCCCCCH	66.95	7670169
72	Phosphorylation	SVHKSWDSFFREASE HHHHHHHHHHHHHHH	21.74	24719451
92	Phosphorylation	SAQPRPPSVVHESRS CCCCCCCCHHCCCHH	39.18	24275569
119	Phosphorylation	EDHLAVQSLIRAYQI HHHHHHHHHHHHHHH	21.11	24719451
178	Phosphorylation	KEFQLPTTTFIGGSE CCCCCCCCEEECCCC	20.12	22468782
179	Phosphorylation	EFQLPTTTFIGGSEN CCCCCCCEEECCCCC	18.74	22468782
184	Phosphorylation	TTTFIGGSENTLSLR CCEEECCCCCCCCHH	23.59	-
189	Phosphorylation	GGSENTLSLREIIRR CCCCCCCCHHHHHHH	24.28	24719451
258	Acetylation	FEDFLARKWSSEKRF HHHHHHHCCCCCCCC	45.91	30585497
263	Acetylation	ARKWSSEKRFGLEGC HHCCCCCCCCCCCCC	55.78	7395485
354	Phosphorylation	RVTNRNITLSLVANP CCCCCCCEEEEEECH	17.53	-
356	Phosphorylation	TNRNITLSLVANPSH CCCCCEEEEEECHHH	16.49	-
362	Phosphorylation	LSLVANPSHLEAVDP EEEEECHHHHHHCCH	40.28	-
444	Phosphorylation	TDPRMARSSPYPTDV CCHHHHCCCCCCCHH	26.57	21406692
445	Phosphorylation	DPRMARSSPYPTDVA CHHHHCCCCCCCHHH	23.93	21406692
447	Phosphorylation	RMARSSPYPTDVARV HHHCCCCCCCHHHHH	22.25	21406692
449	Phosphorylation	ARSSPYPTDVARVVN HCCCCCCCHHHHHHC	36.94	21406692
509	Phosphorylation	EMDEPMFTQPLMYKQ CCCCCCCCCHHHHHH	24.03	29507054
525	Ubiquitination	HRQVPVLKKYADKLI HHHCHHHHHHHHHHH	43.93	-
588	Phosphorylation	NVDGEPKSMTCPATG CCCCCCCCCCCCCCC	30.00	23403867
610	Phosphorylation	HIGSVASSVPLEDFK HHHHCCCCCCHHHCC	20.30	23403867
620	Phosphorylation	LEDFKIHTGLSRILR HHHCCCCHHHHHHHC	43.20	23403867
623	Phosphorylation	FKIHTGLSRILRGRA CCCCHHHHHHHCCCC	20.72	23403867
633	Phosphorylation	LRGRADMTKNRTVDW HCCCCCCCCCCCHHH	26.22	-
637	Phosphorylation	ADMTKNRTVDWALAE CCCCCCCCHHHHHHH	32.01	-
650	Phosphorylation	AEYMAFGSLLKEGIH HHHHHHHHHHHCCCE	24.87	24719451
669	Phosphorylation	GQDVERGTFSHRHHV CCCCCCCCCCCCCCC	28.34	24719451
671	Phosphorylation	DVERGTFSHRHHVLH CCCCCCCCCCCCCCC	21.32	24719451
844	Phosphorylation	RKPLIIFTPKSLLRH CCCEEEECCHHHHCC	21.28	-
847	Phosphorylation	LIIFTPKSLLRHPEA EEEECCHHHHCCHHH	33.56	24719451
856	Phosphorylation	LRHPEAKSSFDQMVS HCCHHHHCHHHHHCC	43.20	27732954
857	Phosphorylation	RHPEAKSSFDQMVSG CCHHHHCHHHHHCCC	31.94	27732954
866	Phosphorylation	DQMVSGTSFQRVIPE HHHCCCCCCEEECCC	23.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OGDHL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OGDHL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OGDHL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	21988832
SMYD1_HUMAN	SMYD1	physical	23455924

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.