| UniProt ID | SHPK_HUMAN | |
|---|---|---|
| UniProt AC | Q9UHJ6 | |
| Protein Name | Sedoheptulokinase | |
| Gene Name | SHPK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 478 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Acts as a modulator of macrophage activation through control of glucose metabolism.. | |
| Protein Sequence | MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAARPITLG ------CCCCCEEEE | 16.51 | - | |
| 30 | Phosphorylation | RAAPDDPSGFAVLAS HHCCCCCCHHHHHHH | 54.24 | 21406692 | |
| 37 | Phosphorylation | SGFAVLASCARAARA CHHHHHHHHHHHHHH | 12.26 | 21406692 | |
| 145 | Phosphorylation | ASLPQPKSHLSVATG HCCCCCCCCCCHHHH | 36.02 | 22210691 | |
| 148 | Phosphorylation | PQPKSHLSVATGFGC CCCCCCCCHHHHCHH | 12.32 | 22210691 | |
| 389 | Phosphorylation | LASVTRISSSDLSLG HHHCEEECCCCCCHH | 22.09 | 29978859 | |
| 390 | Phosphorylation | ASVTRISSSDLSLGH HHCEEECCCCCCHHH | 26.04 | 29978859 | |
| 391 | Phosphorylation | SVTRISSSDLSLGHV HCEEECCCCCCHHHH | 35.46 | 29978859 | |
| 394 | Phosphorylation | RISSSDLSLGHVTRA EECCCCCCHHHHHHH | 36.98 | 29978859 | |
| 399 | Phosphorylation | DLSLGHVTRALCRGI CCCHHHHHHHHHHHH | 12.44 | 29978859 | |
| 426 | Methylation | LQDWGVERVMGSGSA HHHHCCHHHCCCCCC | 22.70 | 115916957 | |
| 441 | Ubiquitination | LSRNDVLKQEVQRAF CCHHHHHHHHHHHHC | 44.24 | 21906983 | |
| 476 | Ubiquitination | LRRHLNQKES----- HHHHHHHCCC----- | 59.87 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SHPK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SHPK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SHPK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRAF3_HUMAN | TRAF3 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
