RASF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASF6_HUMAN
• UniProt AC: Q6ZTQ3
• Protein Name: Ras association domain-containing protein 6
• Gene Name: RASSF6
• Organism: Homo sapiens (Human).
• Sequence Length: 369
• Protein Description: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity)..
• Protein Sequence: MLWEETGAAPAPARASDLPYRISSDHLKKEEKMTMMAHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFWGVKRPIQLKIQDEKPFSSFTSMKSSDVFSSKGMTRWGEFDDLYRISELDRTQIPMSEKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALVRKRMKPLMMDRKERQKNRASINGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MLWEETGAAPAPA --CCCCCCCCCCCCC	22.17	29083192
40	Phosphorylation	MTMMAHQYPSWIFIN HHHHHHHCCCEEEEC	6.86	30576142
59	Phosphorylation	ITREQLNSLLKTYNI CCHHHHHHHHHHHHH	43.61	24719451
108	Phosphorylation	PIQLKIQDEKPFSSF CEEEEECCCCCCCCC	70.16	32142685
113	Phosphorylation	IQDEKPFSSFTSMKS ECCCCCCCCCCCCCH	32.82	28857561
114	Phosphorylation	QDEKPFSSFTSMKSS CCCCCCCCCCCCCHH	32.68	28857561
116	Phosphorylation	EKPFSSFTSMKSSDV CCCCCCCCCCCHHHC	29.84	28857561
117	Phosphorylation	KPFSSFTSMKSSDVF CCCCCCCCCCHHHCC	23.39	28857561
120	Phosphorylation	SSFTSMKSSDVFSSK CCCCCCCHHHCCCCC	24.11	32142685
121	Phosphorylation	SFTSMKSSDVFSSKG CCCCCCHHHCCCCCC	32.07	25278378
125	Phosphorylation	MKSSDVFSSKGMTRW CCHHHCCCCCCCCCC	30.87	25278378
126 (in isoform 3)	Ubiquitination	-	23.05	21906983
126	Phosphorylation	KSSDVFSSKGMTRWG CHHHCCCCCCCCCCC	23.05	25278378
130	Phosphorylation	VFSSKGMTRWGEFDD CCCCCCCCCCCCCCH	31.75	25278378
138 (in isoform 4)	Ubiquitination	-	3.13	21906983
138 (in isoform 2)	Ubiquitination	-	3.13	21906983
152	Phosphorylation	DRTQIPMSEKRNSQE CCCCCCCCCCCCCHH	34.31	32142685
157	Phosphorylation	PMSEKRNSQEDYLSY CCCCCCCCHHHHHHH	38.69	23312004
161	Phosphorylation	KRNSQEDYLSYHSNT CCCCHHHHHHHCCCC	9.22	23312004
163	Phosphorylation	NSQEDYLSYHSNTLK CCHHHHHHHCCCCCC	17.99	23312004
164	Phosphorylation	SQEDYLSYHSNTLKP CHHHHHHHCCCCCCC	13.48	23312004
166	Phosphorylation	EDYLSYHSNTLKPHA HHHHHHCCCCCCCCC	24.23	23312004
168	Phosphorylation	YLSYHSNTLKPHAKD HHHHCCCCCCCCCCC	38.89	23312004
170 (in isoform 1)	Ubiquitination	-	32.49	21906983
170	Ubiquitination	SYHSNTLKPHAKDEP HHCCCCCCCCCCCCC	32.49	2190698
179	Phosphorylation	HAKDEPDSPVLYRTM CCCCCCCCCHHHHCC	27.85	22617229
185	Phosphorylation	DSPVLYRTMSEAALV CCCHHHHCCCHHHHH	16.11	26657352
187	Phosphorylation	PVLYRTMSEAALVRK CHHHHCCCHHHHHHH	24.38	30108239
360	Ubiquitination	ILKCLQNKLVIKTET HHHHHHCCEEEEEEC	31.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RASF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK3_HUMAN	STK3	physical	19797269
SAV1_HUMAN	SAV1	physical	19797269
MOAP1_HUMAN	MOAP1	physical	19797269
KDM3A_HUMAN	KDM3A	physical	26186194
STK3_HUMAN	STK3	physical	26186194
STK4_HUMAN	STK4	physical	26186194
HECD1_HUMAN	HECTD1	physical	26186194
AMY1_HUMAN	AMY1A	physical	24366813
STK4_HUMAN	STK4	physical	24366813
STK3_HUMAN	STK3	physical	24366813
KDM3A_HUMAN	KDM3A	physical	28514442
STK4_HUMAN	STK4	physical	28514442
STK3_HUMAN	STK3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.