IFIX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFIX_HUMAN
• UniProt AC: Q6K0P9
• Protein Name: Pyrin and HIN domain-containing protein 1
• Gene Name: PYHIN1
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Isoform 1: Nucleus, nucleoplasm.; Isoform 3: Nucleus, nucleoplasm.; Isoform 5: Nucleus. Nucleus speckle.
• Protein Description: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells..
• Protein Sequence: MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACTPSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRITSPTVAPPLSSDTSTNRHPAVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MANNYKKIVLLK ---CCCCCCEEEEEE	17.29	19835603
20	Phosphorylation	GLEVINDYHFRIVKS CCEEECHHHHHHHHH	9.81	-
40	Acetylation	LKLNPKMKEEYDKIQ CCCCHHHHHHHHHHC	54.22	20167786
45	Acetylation	KMKEEYDKIQIADLM HHHHHHHHHCHHHHH	35.29	20167786
104	Phosphorylation	PVKGIIPSKKTKQKE CCCCCCCCCCCCCCC	36.05	24719451
143	Phosphorylation	PQKRKKPSEEETGTK CCCCCCCCHHHHCCC	67.53	28060719
176	Phosphorylation	TSTAMGRSPPPQTSS CCCCCCCCCCCCCCC	35.71	30108239
181	Phosphorylation	GRSPPPQTSSSAPPN CCCCCCCCCCCCCCC	36.03	30108239
198	Ubiquitination	STESLKPLANRHATA CCCCHHHHHHCCCCC	6.70	29967540
207	Ubiquitination	NRHATASKNIFREDP HCCCCCCCCCCCCCC	52.15	29967540
228	Phosphorylation	NATKVFKYESSENEQ CCEEEEEECCCHHHH	15.02	-
247	Phosphorylation	HATVATQTQFFHVKV EEEECCCCCEEEEEE	24.00	-
321	Phosphorylation	INILHKQTSGYIVYG CCEEECCCCCCCEEE	28.99	24719451
386	Phosphorylation	LRKRENMSKLMSEMH HHHHHCHHHHHHHHH	33.93	-
390	Phosphorylation	ENMSKLMSEMHSFIQ HCHHHHHHHHHHHHH	42.05	-
425	Phosphorylation	QSQHPKPSEASTTLP HHCCCCCCCCCCCCC	52.50	22673903
428	Phosphorylation	HPKPSEASTTLPESH CCCCCCCCCCCCHHH	20.20	22673903
429	Phosphorylation	PKPSEASTTLPESHL CCCCCCCCCCCHHHC	39.12	22673903
430	Phosphorylation	KPSEASTTLPESHLK CCCCCCCCCCHHHCC	37.51	22673903
434	Phosphorylation	ASTTLPESHLKTPQM CCCCCCHHHCCCCCC	31.98	22673903
438 (in isoform 4)	Phosphorylation	-	25.72	-
447 (in isoform 3)	Phosphorylation	-	40.54	-
450	Phosphorylation	PTTPSSSSFTKKDET CCCCCCCCCCCCCCC	38.59	24719451
453	Ubiquitination	PSSSSFTKKDETHPG CCCCCCCCCCCCCCC	57.10	-
454	Ubiquitination	SSSSFTKKDETHPGA CCCCCCCCCCCCCCC	58.71	-
463	Phosphorylation	ETHPGAQSSPANFRI CCCCCCCCCCCEEEE	37.44	29978859
464	Phosphorylation	THPGAQSSPANFRIT CCCCCCCCCCEEEEC	18.89	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFIX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFIX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFIX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	16479015
TRI26_HUMAN	TRIM26	physical	26186194
SPB5_HUMAN	SERPINB5	physical	26186194
CALL3_HUMAN	CALML3	physical	26186194
DCAF1_HUMAN	VPRBP	physical	26186194
LYG2_HUMAN	LYG2	physical	26186194
S10A3_HUMAN	S100A3	physical	26186194
PLCD1_HUMAN	PLCD1	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
LEG3_HUMAN	LGALS3	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
NEUR2_HUMAN	NEU2	physical	26186194
CRBG1_HUMAN	AIM1	physical	26186194
FA26D_HUMAN	FAM26D	physical	26186194
PADI3_HUMAN	PADI3	physical	26186194
MDM2_HUMAN	MDM2	physical	26186194
TRI26_HUMAN	TRIM26	physical	28514442
PADI3_HUMAN	PADI3	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
CRBG1_HUMAN	AIM1	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
PLCD1_HUMAN	PLCD1	physical	28514442
S10A3_HUMAN	S100A3	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
NEUR2_HUMAN	NEU2	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.