XKR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XKR4_HUMAN
• UniProt AC: Q5GH76
• Protein Name: XK-related protein 4
• Gene Name: XKR4
• Organism: Homo sapiens (Human).
• Sequence Length: 650
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAAKSDGRLKMKKSSDVAFTPLQNSDHSGSVQGLAPGLPSGSGAEDEEAAGGGCCPDGGGCSRCCCCCAGSGGSAGSGGSGGVAGPGGGGAGSAALCLRLGREQRRYSLWDCLWILAAVAVYFADVGTDVWLAVDYYLRGQRWWFGLTLFFVVLGSLSVQVFSFRWFVHDFSTEDSATAAAASSCPQPGADCKTVVGGGSAAGEGEARPSTPQRQASNASKSNIAAANSGSNSSGATRASGKHRSASCSFCIWLLQSLIHILQLGQIWRYFHTIYLGIRSRQSGENDRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLCIIVQTHSLQALQGFTAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARVITFALFASVFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSALWYLYKAPQIADAFAIPALCVVFSSFLTGVVFMLMYYAFFHPNGPRFGQSPSCACEDPAAAFTLPPDVATSTLRSISNNRSVVSDRDQKFAERDGCVPVFQVRPTAPSTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSPSPPRLQYKDDALIQERLEYETTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	SLSVQVFSFRWFVHD HHHHHEEEEEEEEEC	18.29	24719451
200	Phosphorylation	KTVVGGGSAAGEGEA CEEECCCCCCCCCCC	20.44	-
210	Phosphorylation	GEGEARPSTPQRQAS CCCCCCCCCHHHHHH	47.36	23312004
211	Phosphorylation	EGEARPSTPQRQASN CCCCCCCCHHHHHHC	26.56	28857561
280	Phosphorylation	TIYLGIRSRQSGEND HHHHHHHCCCCCCCC	32.52	-
548	Phosphorylation	VATSTLRSISNNRSV HHHHHHHHHHCCCCC	33.22	29083192
550	Phosphorylation	TSTLRSISNNRSVVS HHHHHHHHCCCCCCC	29.33	29083192
554	Phosphorylation	RSISNNRSVVSDRDQ HHHHCCCCCCCHHHH	29.06	29083192
557	Phosphorylation	SNNRSVVSDRDQKFA HCCCCCCCHHHHHHH	25.44	29083192
562	Ubiquitination	VVSDRDQKFAERDGC CCCHHHHHHHHHCCC	51.32	32142685
578	Phosphorylation	PVFQVRPTAPSTPSS EEEEECCCCCCCCCC	40.41	23312004
581	Phosphorylation	QVRPTAPSTPSSRPP EECCCCCCCCCCCCC	50.95	23312004
582	Phosphorylation	VRPTAPSTPSSRPPR ECCCCCCCCCCCCCC	26.57	23312004
584	Phosphorylation	PTAPSTPSSRPPRIE CCCCCCCCCCCCCCC	38.78	23312004
585	Phosphorylation	TAPSTPSSRPPRIEE CCCCCCCCCCCCCCC	50.43	23312004
626	Phosphorylation	AILAFECSPSPPRLQ HHHHHHCCCCCCCCC	22.63	26699800
628	Phosphorylation	LAFECSPSPPRLQYK HHHHCCCCCCCCCCC	31.10	17081983
648	Phosphorylation	QERLEYETTL----- HHHHHHHCCC-----	32.28	18187866
649	Phosphorylation	ERLEYETTL------ HHHHHHCCC------	20.66	18187866

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XKR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XKR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XKR4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of XKR4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-648 AND THR-649, ANDMASS SPECTROMETRY.
PubMed: 18187866