CCNI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNI_HUMAN
• UniProt AC: Q14094
• Protein Name: Cyclin-I
• Gene Name: CCNI
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Protein Sequence: MKFPGPLENQRLSFLLEKAITREAQMWKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVYRPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKFPGPLEN ------CCCCCCCCC	61.33	21890473
18	Ubiquitination	RLSFLLEKAITREAQ HHHHHHHHHHHHHHH	45.09	21890473
28	Ubiquitination	TREAQMWKVNVRKMP HHHHHHHEEEEECCC	20.70	21890473
33	Ubiquitination	MWKVNVRKMPSNQNV HHEEEEECCCCCCCC	51.37	-
36	Phosphorylation	VNVRKMPSNQNVSPS EEEECCCCCCCCCHH	47.77	19845377
40	Ubiquitination	KMPSNQNVSPSQRDE CCCCCCCCCHHHHHH	6.84	-
43	Phosphorylation	SNQNVSPSQRDEVIQ CCCCCCHHHHHHHHH	30.27	18767875
54	Ubiquitination	EVIQWLAKLKYQFNL HHHHHHHHHHHHHCC	43.26	21890473
98	Ubiquitination	AISCFFLAAKTVEED HHHHHHHHHCCCCCC	11.19	-
112	Ubiquitination	DERIPVLKVLARDSF CCCCCHHHHHHCCCC	35.12	21890473
168	Phosphorylation	TRPQLLFSLPKLSPS CCCHHHHCCCCCCHH	43.67	24719451
200	Phosphorylation	QLLQFRGSMLALAMV HHHHHHHHHHHHHHH	13.33	-
208	Phosphorylation	MLALAMVSLEMEKLI HHHHHHHHHHHHHHC	12.91	-
252	Ubiquitination	HHLSTLQSSLPLNSV HHHHHHHHCCCCCCE	36.63	-
260	Phosphorylation	SLPLNSVYVYRPLKH CCCCCCEEEEECCCC	7.50	22817900
260	Ubiquitination	SLPLNSVYVYRPLKH CCCCCCEEEEECCCC	7.50	-
262	Phosphorylation	PLNSVYVYRPLKHTL CCCCEEEEECCCCEE	6.71	22817900
266	Ubiquitination	VYVYRPLKHTLVTCD EEEEECCCCEEEEEC	36.91	-
274	Ubiquitination	HTLVTCDKGVFRLHP CEEEEECCCEEECCC	60.15	-
277	Ubiquitination	VTCDKGVFRLHPSSV EEECCCEEECCCCCC	10.56	-
281	Ubiquitination	KGVFRLHPSSVPGPD CCEEECCCCCCCCCC	32.65	-
291	Ubiquitination	VPGPDFSKDNSKPEV CCCCCCCCCCCCCCC	62.01	-
295	Ubiquitination	DFSKDNSKPEVPVRG CCCCCCCCCCCCCCC	51.99	21890473
310	Ubiquitination	TAAFYHHLPAASGCK CHHHHHCCHHCCCCC	1.64	-
324	Ubiquitination	KQTSTKRKVEEMEVD CCCCCCCCCHHCCHH	56.40	-
324	Ubiquitination	KQTSTKRKVEEMEVD CCCCCCCCCHHCCHH	56.40	-
334	Phosphorylation	EMEVDDFYDGIKRLY HCCHHHHHHHHHHHH	21.91	25884760
338	Ubiquitination	DDFYDGIKRLYNEDN HHHHHHHHHHHCCCC	41.71	-
366	Phosphorylation	SRQEGHASPCPPLQP CCCCCCCCCCCCCCC	22.74	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCNI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C18_HUMAN	KRT18	physical	21988832
MPIP1_HUMAN	CDC25A	physical	21988832
IL1AP_HUMAN	IL1RAP	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.