5HT7R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT7R_HUMAN
• UniProt AC: P34969
• Protein Name: 5-hydroxytryptamine receptor 7
• Gene Name: HTR7
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase..
• Protein Sequence: MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---MMDVNSSGRPDL ---CCCCCCCCCCCH	26.62	22448645
66	N-linked_Glycosylation	TWDAPPDNASGCGEQ CCCCCCCCCCCCCCC	41.60	22448645
285	Phosphorylation	FPRVEPDSVIALNGI CCCCCCCCEEEECCH	26.58	25850435
317	Phosphorylation	KHERKNISIFKREQK HHHHHCCHHHHHHHH	31.22	24719451
320	Ubiquitination	RKNISIFKREQKAAT HHCCHHHHHHHHHHH	54.04	27667366
401	S-palmitoylation	TYRSLLQCQYRNINR HHHHHHHHHHHHHCH	3.76	-
411	Phosphorylation	RNINRKLSAAGMHEA HHHCHHHHHHHHHHH	21.07	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT7R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT7R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT7R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHBT3_HUMAN	RHOBTB3	physical	22245496
CUL3_HUMAN	CUL3	physical	22245496
GASP1_HUMAN	GPRASP1	physical	15086532
GASP2_HUMAN	GPRASP2	physical	15086532

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.