KLK5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK5_HUMAN
• UniProt AC: Q9Y337
• Protein Name: Kallikrein-5 {ECO:0000312|HGNC:HGNC:6366}
• Gene Name: KLK5 {ECO:0000312|HGNC:HGNC:6366}
• Organism: Homo sapiens (Human).
• Sequence Length: 293
• Subcellular Localization: Secreted.
• Protein Description: May be involved in desquamation..
• Protein Sequence: MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	SNTVPSGSNQDLGAG CCCCCCCCCCCCCCC	35.34	24505115
69	N-linked_Glycosylation	DSSSRIINGSDCDMH CCCCCEECCCCCCCC	41.36	UniProtKB CARBOHYD
173	N-linked_Glycosylation	TKDVRPINVSSHCPS CCCCCCCCCCCCCCC	30.24	UniProtKB CARBOHYD
188	Phosphorylation	AGTKCLVSGWGTTKS CCCEEEEECCCCCCC	18.84	20639409
192	Phosphorylation	CLVSGWGTTKSPQVH EEEECCCCCCCCCCC	25.25	20639409
193	Phosphorylation	LVSGWGTTKSPQVHF EEECCCCCCCCCCCH	26.11	20639409
195	Phosphorylation	SGWGTTKSPQVHFPK ECCCCCCCCCCCHHH	20.62	20639409
208	N-linked_Glycosylation	PKVLQCLNISVLSQK HHHHHHHCHHHHCCC	31.92	17881000
213	Phosphorylation	CLNISVLSQKRCEDA HHCHHHHCCCCCCCC	31.34	-
252	N-linked_Glycosylation	SGGPVVCNGSLQGLV CCCCEEECCCEECEE	31.32	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB4A_HUMAN	TUBB4A	physical	26186194
TBB3_HUMAN	TUBB3	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
INT14_HUMAN	VWA9	physical	26186194
FREM2_HUMAN	FREM2	physical	26186194
MET13_HUMAN	METTL13	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
ITB5_HUMAN	ITGB5	physical	26186194
NEUR3_HUMAN	NEU3	physical	26186194
OS9_HUMAN	OS9	physical	26186194
CBWD1_HUMAN	CBWD1	physical	26186194
FRAS1_HUMAN	FRAS1	physical	26186194
PASK_HUMAN	PASK	physical	26186194
EME1_HUMAN	EME1	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
DPOE2_HUMAN	POLE2	physical	26186194
PCDH7_HUMAN	PCDH7	physical	26186194
AP3S1_HUMAN	AP3S1	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
LCHN_HUMAN	KIAA1147	physical	26186194
TTC5_HUMAN	TTC5	physical	26186194
PYC_HUMAN	PC	physical	26186194
CHD1L_HUMAN	CHD1L	physical	26186194
BBS7_HUMAN	BBS7	physical	26186194
GT253_HUMAN	CERCAM	physical	26186194
COX11_HUMAN	COX11	physical	26186194
CPNE1_HUMAN	CPNE1	physical	26186194
TRM44_HUMAN	TRMT44	physical	26186194
CELR2_HUMAN	CELSR2	physical	26186194
MKS1_HUMAN	MKS1	physical	26186194
MCM8_HUMAN	MCM8	physical	26186194
FUK_HUMAN	FUK	physical	26186194
FUK_HUMAN	FUK	physical	28514442
DPOE2_HUMAN	POLE2	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
LCHN_HUMAN	KIAA1147	physical	28514442
AP3S1_HUMAN	AP3S1	physical	28514442
ITB5_HUMAN	ITGB5	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
MET13_HUMAN	METTL13	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
CPNE1_HUMAN	CPNE1	physical	28514442
EME1_HUMAN	EME1	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
COX11_HUMAN	COX11	physical	28514442
ARSA_HUMAN	ARSA	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
OS9_HUMAN	OS9	physical	28514442
PASK_HUMAN	PASK	physical	28514442
MCM8_HUMAN	MCM8	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structural basis of the zinc inhibition of human tissue kallikrein5.";
Debela M., Goettig P., Magdolen V., Huber R., Schechter N.M., Bode W.;
J. Mol. Biol. 373:1017-1031(2007).
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 67-293 ALONE AND IN COMPLEXWITH ZINC, ENZYME REGULATION, ACTIVE SITE, GLYCOSYLATION AT ASN-208,AND DISULFIDE BONDS.
PubMed: 17881000