CK5P1_HUMAN - dbPTM
CK5P1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CK5P1_HUMAN
UniProt AC Q96SZ6
Protein Name CDK5 regulatory subunit-associated protein 1
Gene Name CDK5RAP1
Organism Homo sapiens (Human).
Sequence Length 601
Subcellular Localization
Protein Description Specifically inhibits CDK5 activation by CDK5R1..
Protein Sequence MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationLRMCRAHSSLSSTMC
HHHHHHHHCCCCCCC		31.8030206219
35PhosphorylationRMCRAHSSLSSTMCP
HHHHHHHCCCCCCCC		23.5430206219
37PhosphorylationCRAHSSLSSTMCPSP
HHHHHCCCCCCCCCH		26.2230206219
38PhosphorylationRAHSSLSSTMCPSPE
HHHHCCCCCCCCCHH		26.0030206219
39PhosphorylationAHSSLSSTMCPSPER
HHHCCCCCCCCCHHH		21.2930206219
43PhosphorylationLSSTMCPSPERQEDG
CCCCCCCCHHHCCCC		34.1730206219
70UbiquitinationPTFQHFLKSASAPQE
HHHHHHHHHCCCCHH		42.9321890473
70UbiquitinationPTFQHFLKSASAPQE
HHHHHHHHHCCCCHH		42.9321890473
70UbiquitinationPTFQHFLKSASAPQE
HHHHHHHHHCCCCHH		42.9321890473
70 (in isoform 1)Ubiquitination-42.9321890473
70 (in isoform 3)Ubiquitination-42.9321890473
70 (in isoform 4)Ubiquitination-42.9321890473
71UbiquitinationTFQHFLKSASAPQEK
HHHHHHHHCCCCHHH		29.60-
78UbiquitinationSASAPQEKLSSEVED
HCCCCHHHHCCCCCC		48.71-
78UbiquitinationSASAPQEKLSSEVED
HCCCCHHHHCCCCCC		48.7121906983
78 (in isoform 1)Ubiquitination-48.7121890473
78 (in isoform 3)Ubiquitination-48.7121890473
78 (in isoform 4)Ubiquitination-48.7121890473
79UbiquitinationASAPQEKLSSEVEDP
CCCCHHHHCCCCCCC		7.19-
80PhosphorylationSAPQEKLSSEVEDPP
CCCHHHHCCCCCCCC		35.2027174698
81PhosphorylationAPQEKLSSEVEDPPP
CCHHHHCCCCCCCCC		56.9827174698
89PhosphorylationEVEDPPPYLMMDELL
CCCCCCCCCCHHHHH		17.0127174698
99 (in isoform 2)Ubiquitination-47.9921890473
107 (in isoform 2)Ubiquitination-13.4121890473
164UbiquitinationNRLHQLKALKTRRPR
HHHHHHHHHHCCCCC		23.92-
189UbiquitinationGCMAERLKEEILNRE
HHHHHHHHHHHHCHH		60.571890473
189 (in isoform 1)Ubiquitination-60.5721890473
189 (in isoform 3)Ubiquitination-60.5721890473
189 (in isoform 4)Ubiquitination-60.5721890473
190UbiquitinationCMAERLKEEILNREK
HHHHHHHHHHHCHHH		55.66-
197UbiquitinationEEILNREKMVDILAG
HHHHCHHHHHHHHHC		40.7721906983
197 (in isoform 1)Ubiquitination-40.7721890473
197 (in isoform 2)Ubiquitination-40.7721890473
197 (in isoform 3)Ubiquitination-40.7721890473
197 (in isoform 4)Ubiquitination-40.7721890473
198UbiquitinationEILNREKMVDILAGP
HHHCHHHHHHHHHCC		2.54-
205 (in isoform 2)Ubiquitination-19.9021890473
208PhosphorylationILAGPDAYRDLPRLL
HHHCCHHHHCHHHHH		16.4326074081
220PhosphorylationRLLAVAESGQQAANV
HHHHHHHHHHHHHHH		31.9726074081
230PhosphorylationQAANVLLSLDETYAD
HHHHHHHHCCCCCCC		29.6126074081
234PhosphorylationVLLSLDETYADVMPV
HHHHCCCCCCCCCCC		24.5526074081
235PhosphorylationLLSLDETYADVMPVQ
HHHCCCCCCCCCCCC		9.9626074081
243PhosphorylationADVMPVQTSASATSA
CCCCCCCCCCHHHHH		26.8824043423
244PhosphorylationDVMPVQTSASATSAF
CCCCCCCCCHHHHHH		11.7924043423
246PhosphorylationMPVQTSASATSAFVS
CCCCCCCHHHHHHHH		31.6724043423
248PhosphorylationVQTSASATSAFVSIM
CCCCCHHHHHHHHHH		20.3524043423
249PhosphorylationQTSASATSAFVSIMR
CCCCHHHHHHHHHHC		21.3024043423
253PhosphorylationSATSAFVSIMRGCDN
HHHHHHHHHHCCCCC		12.2924043423
274 (in isoform 2)Ubiquitination-58.8121890473
287UbiquitinationASILEEVKKLSEQVF
HHHHHHHHHHHHHCC		51.80-
287UbiquitinationASILEEVKKLSEQVF
HHHHHHHHHHHHHCC		51.8021906983
287 (in isoform 1)Ubiquitination-51.8021890473
287 (in isoform 3)Ubiquitination-51.8021890473
287 (in isoform 4)Ubiquitination-51.8021890473
288UbiquitinationSILEEVKKLSEQVFL
HHHHHHHHHHHHCCC		63.52-
288 (in isoform 3)Ubiquitination-63.52-
295UbiquitinationKLSEQVFLPPRPPKV
HHHHHCCCCCCCCCC		6.32-
295 (in isoform 3)Ubiquitination-6.3221890473
298MethylationEQVFLPPRPPKVLGL
HHCCCCCCCCCCCCC		59.21-
320PhosphorylationLLGQNVNSFRDNSEV
ECCCCCCCCCCCCCC		19.8524719451
325PhosphorylationVNSFRDNSEVQFNSA
CCCCCCCCCCCCCCC		43.3522210691
332UbiquitinationSEVQFNSAVPTNLSR
CCCCCCCCCCCCCCC		16.65-
332 (in isoform 3)Ubiquitination-16.65-
333UbiquitinationEVQFNSAVPTNLSRG
CCCCCCCCCCCCCCC		6.36-
335PhosphorylationQFNSAVPTNLSRGFT
CCCCCCCCCCCCCCC		42.0422210691
343PhosphorylationNLSRGFTTNYKTKQG
CCCCCCCCCCCCCCC		34.0022210691
364UbiquitinationLLDQVSRVDPEMRIR
HHHHHHCCCHHHCEE		12.8621890473
364UbiquitinationLLDQVSRVDPEMRIR
HHHHHHCCCHHHCEE		12.8621890473
364 (in isoform 3)Ubiquitination-12.8621890473
365UbiquitinationLDQVSRVDPEMRIRF
HHHHHCCCHHHCEEE		32.12-
378UbiquitinationRFTSPHPKDFPDEVL
EECCCCCCCCCHHHH		69.8121890473
378 (in isoform 1)Ubiquitination-69.8121890473
382UbiquitinationPHPKDFPDEVLQLIH
CCCCCCCHHHHHHHH		59.64-
382 (in isoform 3)Ubiquitination-59.64-
383UbiquitinationHPKDFPDEVLQLIHE
CCCCCCHHHHHHHHH		45.42-
383 (in isoform 2)Ubiquitination-45.4221890473
391 (in isoform 2)Ubiquitination-28.2821890473
396UbiquitinationHERDNICKQIHLPAQ
HHHCCCHHHCCCCCC		48.79-
396 (in isoform 4)Ubiquitination-48.7921890473
404 (in isoform 4)Ubiquitination-42.6321890473
406PhosphorylationHLPAQSGSSRVLEAM
CCCCCCCCHHHHHHH		21.88-
409PhosphorylationAQSGSSRVLEAMRRG
CCCCCHHHHHHHHCC		6.47-
417PhosphorylationLEAMRRGYSREAYVE
HHHHHCCCCHHHHHH		11.6224043423
418PhosphorylationEAMRRGYSREAYVEL
HHHHCCCCHHHHHHH		26.8624043423
422PhosphorylationRGYSREAYVELVHHI
CCCCHHHHHHHHHHH		6.95-
442 (in isoform 2)Ubiquitination-4.4421890473
455 (in isoform 4)Ubiquitination-8.6921890473
473 (in isoform 3)Ubiquitination-9.5321890473
474UbiquitinationNMGFLFAYSMRQKTR
HHHHHHHHHHHHHHH		8.82-
481 (in isoform 3)Ubiquitination-39.9421890473
482UbiquitinationSMRQKTRAYHRLKDD
HHHHHHHHHHHCCCC		15.09-
483PhosphorylationMRQKTRAYHRLKDDV
HHHHHHHHHHCCCCC		5.56-
487UbiquitinationTRAYHRLKDDVPEEV
HHHHHHCCCCCCHHH		52.4121906983
487 (in isoform 1)Ubiquitination-52.4121890473
495UbiquitinationDDVPEEVKLRRLEEL
CCCCHHHHHHHHHHH		39.2921906983
495 (in isoform 1)Ubiquitination-39.2921890473
517 (in isoform 3)Ubiquitination-13.52-
518UbiquitinationTKANQTSVGCTQLVL
HHCCCCCCCCCCEEE		9.19-
532 (in isoform 3)Ubiquitination-28.3121890473
533AcetylationVEGLSKRSATDLCGR
EECCCCCCHHHHCCC		38.98-
533UbiquitinationVEGLSKRSATDLCGR
EECCCCCCHHHHCCC		38.98-
546AcetylationGRNDGNLKVIFPDAE
CCCCCCEEEECCCHH		36.9723236377
546UbiquitinationGRNDGNLKVIFPDAE
CCCCCCEEEECCCHH		36.972190698
546 (in isoform 1)Ubiquitination-36.9721890473
577PhosphorylationDYVLVKITSASSQTL
CEEEEEEECCCCCCC		16.7221406692
578PhosphorylationYVLVKITSASSQTLR
EEEEEEECCCCCCCC		29.6221406692
580PhosphorylationLVKITSASSQTLRGH
EEEEECCCCCCCCCE		23.8121406692
581PhosphorylationVKITSASSQTLRGHV
EEEECCCCCCCCCEE		27.2221406692
583PhosphorylationITSASSQTLRGHVLC
EECCCCCCCCCEEEE		21.9921406692
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CK5P1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CK5P1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CK5P1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CD5R1_HUMANCDK5R1physical
10915792
ZMY19_HUMANZMYND19physical
28514442
NDUF5_HUMANNDUFAF5physical
28514442
XRCC6_HUMANXRCC6physical
28514442
XRCC5_HUMANXRCC5physical
28514442
ZZEF1_HUMANZZEF1physical
28514442
ARMC8_HUMANARMC8physical
28514442
MATR3_HUMANMATR3physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CK5P1_HUMAN

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Related Literatures of Post-Translational Modification

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