FHR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FHR4_HUMAN
• UniProt AC: Q92496
• Protein Name: Complement factor H-related protein 4
• Gene Name: CFHR4
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Secreted.
• Protein Description: Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism..
• Protein Sequence: MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATAEGNSSGSITCLQNGWSTQPICIKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYESSYGNTTDSIVCGEDGWSHLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSRVEYQCQSYYELQGSKYVTCSNGDWSEPPRCISMKPCEFPEIQHGHLYYENTRRPYFPVATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	CLRTCSKSDVEIENG EECEECCCCEEEECC	27.76	29978859
101	Phosphorylation	EIENGFISESSSIYI EEECCEECCCCEEEE	29.21	29978859
103	Phosphorylation	ENGFISESSSIYILN ECCEECCCCEEEECC	23.69	29978859
104	Phosphorylation	NGFISESSSIYILNE CCEECCCCEEEECCC	19.39	29978859
105	Phosphorylation	GFISESSSIYILNEE CEECCCCEEEECCCC	28.79	29978859
107	Phosphorylation	ISESSSIYILNEETQ ECCCCEEEECCCCCC	10.99	29978859
113	Phosphorylation	IYILNEETQYNCKPG EEECCCCCCCCCCCC	6.07	29978859
115	Phosphorylation	ILNEETQYNCKPGYA ECCCCCCCCCCCCCE	24.82	29978859
127	N-linked_Glycosylation	GYATAEGNSSGSITC CCEECCCCCCCCEEE	33.28	UniProtKB CARBOHYD
186	N-linked_Glycosylation	GYESSYGNTTDSIVC CCCCCCCCCCCCEEE	26.66	UniProtKB CARBOHYD
206	N-linked_Glycosylation	SHLPTCYNSSENCGP CCCCCCCCCCCCCCC	41.00	UniProtKB CARBOHYD
218	Phosphorylation	CGPPPPISNGDTTSF CCCCCCCCCCCCCCC	40.30	-
251	Phosphorylation	YELQGSKYVTCSNGD EEECCCEEEECCCCC	9.99	29449344
253	Phosphorylation	LQGSKYVTCSNGDWS ECCCEEEECCCCCCC	10.39	29449344
255	Phosphorylation	GSKYVTCSNGDWSEP CCEEEECCCCCCCCC	38.20	29449344
260	Phosphorylation	TCSNGDWSEPPRCIS ECCCCCCCCCCEEEE	35.60	29449344
267	Phosphorylation	SEPPRCISMKPCEFP CCCCEEEEECCCCCC	18.14	29449344
374	N-linked_Glycosylation	GYATADGNSSGSITC CEEECCCCCCCCEEE		UniProtKB CARBOHYD
408	Phosphorylation	FENSRAKSNGMRFKL CCCCCHHHCCCCEEE		-
433	N-linked_Glycosylation	GYEISYGNTTGSIVC CEEEEECCCCCEEEE		UniProtKB CARBOHYD
453	N-linked_Glycosylation	SHFPTCYNSSEKCGP CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
465	Phosphorylation	CGPPPPISNGDTTSF CCCCCCCCCCCCCEE		-
469	Phosphorylation	PPISNGDTTSFLLKV CCCCCCCCCEEEEEE		-
470	Phosphorylation	PISNGDTTSFLLKVY CCCCCCCCEEEEEEE		-
471	Phosphorylation	ISNGDTTSFLLKVYV CCCCCCCEEEEEEEC		-
557	N-linked_Glycosylation	CKLGYNANTSVLSFQ HHCCCCCCCCEEEEE		UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FHR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FHR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FHR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FHR4_HUMAN	CFHR4	physical	9038172
CO3_HUMAN	C3	physical	10622723

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.