dbPTM

PKHG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKHG2_HUMAN
UniProt AC	Q9H7P9
Protein Name	Pleckstrin homology domain-containing family G member 2
Gene Name	PLEKHG2
Organism	Homo sapiens (Human).
Sequence Length	1386
Subcellular Localization
Protein Description	May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). [PubMed: 18045877 Involved in the regulation of actin polymerization]
Protein Sequence	MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAPDAPFHM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PEGAQGLSLSKPSPS CCCCCCCCCCCCCCC	37.10	23663014
11	Phosphorylation	GAQGLSLSKPSPSLG CCCCCCCCCCCCCCC	38.86	23663014
14	Phosphorylation	GLSLSKPSPSLGCGR CCCCCCCCCCCCCCC	30.75	23663014
16	Phosphorylation	SLSKPSPSLGCGRRG CCCCCCCCCCCCCCC	41.55	23663014
42	Phosphorylation	RTAPAAPTMASPRGS CCCCCCCCCCCCCCC	22.20	24719451
45	Phosphorylation	PAAPTMASPRGSGSS CCCCCCCCCCCCCCC	12.33	23403867
49	Phosphorylation	TMASPRGSGSSTSLS CCCCCCCCCCCCCCC	36.46	23663014
51	Phosphorylation	ASPRGSGSSTSLSTV CCCCCCCCCCCCCCC	31.94	23663014
52	Phosphorylation	SPRGSGSSTSLSTVG CCCCCCCCCCCCCCC	26.07	23663014
53	Phosphorylation	PRGSGSSTSLSTVGS CCCCCCCCCCCCCCC	35.07	23663014
54	Phosphorylation	RGSGSSTSLSTVGSE CCCCCCCCCCCCCCC	23.44	23663014
56	Phosphorylation	SGSSTSLSTVGSEGD CCCCCCCCCCCCCCC	22.33	23663014
57	Phosphorylation	GSSTSLSTVGSEGDP CCCCCCCCCCCCCCC	33.89	23663014
60	Phosphorylation	TSLSTVGSEGDPAPG CCCCCCCCCCCCCCC	33.79	26074081
69	Phosphorylation	GDPAPGPTPACSASR CCCCCCCCCCCCCCC	29.45	26074081
73	Phosphorylation	PGPTPACSASRPEPL CCCCCCCCCCCCCCC	31.24	26074081
75	Phosphorylation	PTPACSASRPEPLPG CCCCCCCCCCCCCCC	31.88	26074081
90	Phosphorylation	PPIRLHLSPVGIPGS CCEEEEEECCCCCCC	13.54	30266825
97	Phosphorylation	SPVGIPGSARPSRLE ECCCCCCCCCHHHHH	18.75	26074081
101	Phosphorylation	IPGSARPSRLERVAR CCCCCCHHHHHHHHH	43.90	21712546
113	Phosphorylation	VAREIVETERAYVRD HHHHHHHHHHHHHHH	21.63	22210691
117	Phosphorylation	IVETERAYVRDLRSI HHHHHHHHHHHHHHH	11.39	22210691
260	Phosphorylation	HWAEGPGTGGREMVE HHHCCCCCCHHHHHH	39.33	-
272	Phosphorylation	MVEEAIVSMTAVAWY HHHHHHHHHHHHHHH	12.33	-
274	Phosphorylation	EEAIVSMTAVAWYIN HHHHHHHHHHHHHHH	15.52	22210691
321	Methylation	LVLEGAFRGGGGGGP HHHHCCCCCCCCCCC	42.17	115388759
329	Methylation	GGGGGGPRLRGGERL CCCCCCCCCCCHHHH	40.05	54558069
378	Ubiquitination	PRDPLGFKVSDLTIP CCCCCCCCHHHCCCC	38.74	-
386	Phosphorylation	VSDLTIPKHRHLLQA HHHCCCCCHHHHHHH	49.79	32645325
386	Ubiquitination	VSDLTIPKHRHLLQA HHHCCCCCHHHHHHH	49.79	29967540
391	Phosphorylation	IPKHRHLLQAKNQEE CCCHHHHHHHCCHHH	3.67	32142685
394	Ubiquitination	HRHLLQAKNQEEKRL HHHHHHHCCHHHHHH	46.32	29967540
421	Ubiquitination	HPASIPAKAKQVLLE CCCCCCHHHHHHHHH	51.25	-
423	Ubiquitination	ASIPAKAKQVLLENS CCCCHHHHHHHHHCC	39.99	29967540
430	Phosphorylation	KQVLLENSLHCAPKS HHHHHHCCCCCCCCC	15.32	28555341
437	Phosphorylation	SLHCAPKSKPVLEPL CCCCCCCCCCCCCCC	40.93	23403867
445	Phosphorylation	KPVLEPLTPPLGSPR CCCCCCCCCCCCCCC	33.31	25463755
450	Phosphorylation	PLTPPLGSPRPRDAR CCCCCCCCCCCCCCC	25.97	25463755
458	Phosphorylation	PRPRDARSFTPGRRN CCCCCCCCCCCCCCC	34.88	21712546
460	Phosphorylation	PRDARSFTPGRRNTA CCCCCCCCCCCCCCC	26.53	21712546
466	Phosphorylation	FTPGRRNTAPSPGPS CCCCCCCCCCCCCCC	37.83	22617229
469	Phosphorylation	GRRNTAPSPGPSVIR CCCCCCCCCCCCHHC	39.77	26055452
473	Phosphorylation	TAPSPGPSVIRRGRR CCCCCCCCHHCCCCC	35.77	30206219
482	Phosphorylation	IRRGRRQSEPVKDPY HCCCCCCCCCCCCCC	41.90	23401153
489	Phosphorylation	SEPVKDPYVMFPQNA CCCCCCCCCCCCCCC	18.06	27259358
505	Phosphorylation	PGFKHAGSEGELYPP CCCCCCCCCCCCCCC	43.12	27251275
534	Phosphorylation	LEDAGPPTLDPSGTS HHHCCCCCCCCCCCC	47.10	27251275
538	Phosphorylation	GPPTLDPSGTSITEE CCCCCCCCCCCHHHH	55.13	27251275
540	Phosphorylation	PTLDPSGTSITEEIL CCCCCCCCCHHHHHH	22.69	27251275
541	Phosphorylation	TLDPSGTSITEEILE CCCCCCCCHHHHHHH	30.91	27251275
543	Phosphorylation	DPSGTSITEEILELL CCCCCCHHHHHHHHH	27.60	27251275
561	Phosphorylation	GLRDPGPSTHDIPKF CCCCCCCCCCCCCCC	44.27	23403867
562	Phosphorylation	LRDPGPSTHDIPKFP CCCCCCCCCCCCCCC	27.05	23403867
610	Phosphorylation	EMDERGPSPLHVLEG CCCCCCCCCHHHHHH	42.81	25159151
620	Phosphorylation	HVLEGLESSIAAEMP HHHHHHHHHHHHCCC	31.89	28450419
621	Phosphorylation	VLEGLESSIAAEMPS HHHHHHHHHHHCCCC	13.58	28450419
658	Phosphorylation	PEGSRLPSLSDISDV CCCCCCCCHHHCHHH	45.13	26074081
660	Phosphorylation	GSRLPSLSDISDVFE CCCCCCHHHCHHHCC	36.92	26074081
663	Phosphorylation	LPSLSDISDVFEMPC CCCHHHCHHHCCCCC	32.48	26074081
680	Phosphorylation	AIPSVPNTPSLSSTP CCCCCCCCCCCCCCC	14.26	-
714	Phosphorylation	ATRRELFSGSNPGKL CHHHHHHCCCCCCCC	54.67	21815630
716	Phosphorylation	RRELFSGSNPGKLGE HHHHHCCCCCCCCCC	38.36	21712546
720	Ubiquitination	FSGSNPGKLGEPPSG HCCCCCCCCCCCCCC	55.35	29967540
726	Phosphorylation	GKLGEPPSGGKAGPE CCCCCCCCCCCCCCC	71.53	23403867
740	Phosphorylation	EEDEEGVSFTDFQPQ CCCCCCCCCCCCCCC	33.03	21712546
742	Phosphorylation	DEEGVSFTDFQPQDV CCCCCCCCCCCCCCC	28.53	-
765	Phosphorylation	ELAFRSCSEIRSAWQ HHHHHCHHHHHHHHH	36.99	-
825	Phosphorylation	RELARLYSERIQQMQ HHHHHHHHHHHHHHH	25.62	-
911	Phosphorylation	PLSKQGGSPDGQGLH EHHHCCCCCCCCCEE	27.00	25159151
953	Phosphorylation	HVQAPAATPLPKQEG CCCCCCCCCCCCCCC	27.71	28555341
993	Phosphorylation	TPLPEHRSHMVIPAP CCCCCCCCCCCEECC	20.17	24719451
1002	Phosphorylation	MVIPAPSTAFCPEQG CCEECCCCCCCCCCC	23.77	24719451
1047	Phosphorylation	KQEGHLDSESPTNIP CCCCCCCCCCCCCCC	46.46	25159151
1049	Phosphorylation	EGHLDSESPTNIPLT CCCCCCCCCCCCCCC	40.76	25159151
1051	Phosphorylation	HLDSESPTNIPLTKQ CCCCCCCCCCCCCCC	55.87	25159151
1056	Phosphorylation	SPTNIPLTKQGGSRD CCCCCCCCCCCCCCC	18.90	23403867
1162	Phosphorylation	IWVQALPTSPKQGSL HHHHCCCCCCCCCCC	59.52	26074081
1163	Phosphorylation	WVQALPTSPKQGSLP HHHCCCCCCCCCCCC	28.32	26074081
1168	Phosphorylation	PTSPKQGSLPDIQGP CCCCCCCCCCCCCCC	33.95	26074081
1195	Phosphorylation	DTQVQKLTPSLEQKS HHHHHHCCCCHHHHH	20.19	28674419
1202	Phosphorylation	TPSLEQKSLIDAHVP CCCHHHHHCHHCCCC	30.19	28555341
1212	Phosphorylation	DAHVPAATPLPERGG HCCCCCCCCCCCCCC	27.71	28674419
1227	Phosphorylation	SLDIQGLSPTPVQTT CCCCCCCCCCCCEEE	33.29	25159151
1253	Phosphorylation	SHVARLESSDLTPPH HHHHHHHHCCCCCCC	33.47	30266825
1254	Phosphorylation	HVARLESSDLTPPHS HHHHHHHCCCCCCCC	27.54	30266825
1257	Phosphorylation	RLESSDLTPPHSPPP HHHHCCCCCCCCCCC	39.50	22167270
1261	Phosphorylation	SDLTPPHSPPPSSRQ CCCCCCCCCCCCHHC	44.89	22167270
1265	Phosphorylation	PPHSPPPSSRQLLGP CCCCCCCCHHCCCCC	43.88	30266825
1266	Phosphorylation	PHSPPPSSRQLLGPN CCCCCCCHHCCCCCC	29.80	30266825
1278	Phosphorylation	GPNAAALSRYLAASY CCCHHHHHHHHHHHH	17.72	28555341
1285	Phosphorylation	SRYLAASYISQSLAR HHHHHHHHHHHHHHH	10.40	-
1287	Phosphorylation	YLAASYISQSLARRQ HHHHHHHHHHHHHHH	12.89	24719451
1289	Phosphorylation	AASYISQSLARRQGP HHHHHHHHHHHHHCC	19.73	29214152
1304	Phosphorylation	GGGAPAASRGSWSSA CCCCCCHHCCCCCCC	39.00	-
1305	Methylation	GGAPAASRGSWSSAP CCCCCHHCCCCCCCC	38.14	115388753
1307	Phosphorylation	APAASRGSWSSAPTS CCCHHCCCCCCCCCC	23.75	23403867
1309	Phosphorylation	AASRGSWSSAPTSRA CHHCCCCCCCCCCCC	20.51	23403867
1310	Phosphorylation	ASRGSWSSAPTSRAS HHCCCCCCCCCCCCC	31.82	22617229
1313	Phosphorylation	GSWSSAPTSRASSPP CCCCCCCCCCCCCCC	30.48	23403867
1314	O-linked_Glycosylation	SWSSAPTSRASSPPP CCCCCCCCCCCCCCC	25.45	30059200
1314	Phosphorylation	SWSSAPTSRASSPPP CCCCCCCCCCCCCCC	25.45	23403867
1317	Phosphorylation	SAPTSRASSPPPQPQ CCCCCCCCCCCCCCC	42.12	23898821
1318	Phosphorylation	APTSRASSPPPQPQP CCCCCCCCCCCCCCC	40.20	23898821
1334	Phosphorylation	PPPARRLSYATTVNI CCCCCCCCEEEEEEE	15.77	27251275
1335	Phosphorylation	PPARRLSYATTVNIH CCCCCCCEEEEEEEE	16.74	27080861
1337	Phosphorylation	ARRLSYATTVNIHVG CCCCCEEEEEEEEEC	24.04	27080861
1338	Phosphorylation	RRLSYATTVNIHVGG CCCCEEEEEEEEECC	11.90	27080861
1357	Methylation	RPAKAQVRLNHPALL CCCCCCCCCCCHHHH	20.07	115487851
1375	Methylation	QESMGLHRAQGAPDA HHHHCHHHHCCCCCC	33.38	115487857

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
489	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
489	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKHG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKHG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBB1_HUMAN	GNB1	physical	18045877
GBG2_HUMAN	GNG2	physical	18045877
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKHG2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1257 AND SER-1261, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-445 AND SER-450, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, AND MASSSPECTROMETRY.	17081983 [Abstract]