ARHGP_HUMAN - dbPTM
ARHGP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARHGP_HUMAN
UniProt AC Q86VW2
Protein Name Rho guanine nucleotide exchange factor 25
Gene Name ARHGEF25
Organism Homo sapiens (Human).
Sequence Length 580
Subcellular Localization Cell membrane. Cytoplasm, myofibril, sarcomere . Highly colocalizes with actin regions.
Protein Description May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity)..
Protein Sequence MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIQLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12 (in isoform 3)Phosphorylation-2.2422210691
23S-palmitoylationIRKVLAKCGCCFARG
HHHHHHHCCCCEEEC		4.1421832057
25S-palmitoylationKVLAKCGCCFARGGR
HHHHHCCCCEEECCC		2.1221832057
26S-palmitoylationVLAKCGCCFARGGRE
HHHHCCCCEEECCCE		1.4921832057
163PhosphorylationKALERSMYVLSELVE
HHHHHHHHHHHHHHH		10.25-
175PhosphorylationLVETEKMYVDDLGQI
HHHHCCCCCCCHHHH		16.2824043423
186PhosphorylationLGQIVEGYMATMAAQ
HHHHHHHHHHHHHHC		3.1024043423
189PhosphorylationIVEGYMATMAAQGVP
HHHHHHHHHHHCCCC		7.2724043423
198PhosphorylationAAQGVPESLRGRDRI
HHCCCCHHHCCCCCE		19.8024043423
309PhosphorylationLKDFLKYYNRAGMDT
HHHHHHHHHHCCCCH		9.15-
338PhosphorylationKRCNDMMTLGRLRGF
CCCCCCCCHHHHCCC		21.3026074081
373PhosphorylationPEAGGLLSSRGRERR
CCCCCCCCCCCHHHH		24.0324719451
374PhosphorylationEAGGLLSSRGRERRV
CCCCCCCCCCHHHHE		38.4324719451
477PhosphorylationDFLNALQSPIEYQRR
HHHHHHHCHHHHHHH		28.7922617229
481PhosphorylationALQSPIEYQRRESQT
HHHCHHHHHHHHHCC		14.1928060719
486PhosphorylationIEYQRRESQTNSLGR
HHHHHHHHCCCCCCC		40.2629449344
488PhosphorylationYQRRESQTNSLGRPR
HHHHHHCCCCCCCCC		35.7330266825
490PhosphorylationRRESQTNSLGRPRGP
HHHHCCCCCCCCCCC		35.2730266825
501PhosphorylationPRGPGVGSPGRIQLG
CCCCCCCCCCCEEEC		23.0627732954
525PhosphorylationPINGSLPSLLLSPKG
CCCCCCCCHHCCCCC		36.6227251275
529PhosphorylationSLPSLLLSPKGEVAR
CCCCHHCCCCCHHHH		25.2424719451
556PhosphorylationIPQAPHDSPPVSPTP
CCCCCCCCCCCCCCC		28.2430266825
560PhosphorylationPHDSPPVSPTPKTPP
CCCCCCCCCCCCCCC		28.9120363803
562PhosphorylationDSPPVSPTPKTPPCQ
CCCCCCCCCCCCCCC		29.8830266825
565PhosphorylationPVSPTPKTPPCQARL
CCCCCCCCCCCCHHH		33.4025921289
595Phosphorylation----------------------
----------------------		24719451
599Phosphorylation--------------------------
--------------------------		24719451
604Phosphorylation-------------------------------
-------------------------------		27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARHGP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARHGP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARHGP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHOA_HUMANRHOAphysical
15069594
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARHGP_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory