BORG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BORG1_HUMAN
• UniProt AC: O14613
• Protein Name: Cdc42 effector protein 2
• Gene Name: CDC42EP2
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
• Protein Description: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner..
• Protein Sequence: MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTKVPIYL ------CCCCCCEEE	36.61	22167270
2	Acetylation	------MSTKVPIYL ------CCCCCCEEE	36.61	22814378
3	Phosphorylation	-----MSTKVPIYLK -----CCCCCCEEEC	34.46	22167270
8	Phosphorylation	MSTKVPIYLKRGSRK CCCCCCEEECCCCCC	10.49	29978859
26	Phosphorylation	EKLRDLLSSDMISPP HHHHHHHCCCCCCCC	31.43	29396449
27	Phosphorylation	KLRDLLSSDMISPPL HHHHHHCCCCCCCCC	31.03	29396449
31	Phosphorylation	LLSSDMISPPLGDFR HHCCCCCCCCCCCCC	17.52	25159151
45	Phosphorylation	RHTIHIGSGGGSDMF CEEEEECCCCCCCCC	33.39	28555341
49	Phosphorylation	HIGSGGGSDMFGDIS EECCCCCCCCCCCHH	29.22	29214152
56	Phosphorylation	SDMFGDISFLQGKFH CCCCCCHHHHCCCEE	25.33	28555341
88	Phosphorylation	LPFQFTRTATVCGRE CCEEEEEEEEECCCC	24.50	22817900
90	Phosphorylation	FQFTRTATVCGRELP EEEEEEEEECCCCCC	18.73	22817900
101	Phosphorylation	RELPDGPSPLLKNAI CCCCCCCCHHHHCCC	33.44	29255136
109	Phosphorylation	PLLKNAISLPVIGGP HHHHCCCCCCCCCCC	24.98	29255136
120	Phosphorylation	IGGPQALTLPTAQAP CCCCCCEECCCCCCC	33.44	23312004
123	Phosphorylation	PQALTLPTAQAPPKP CCCEECCCCCCCCCC	34.22	23312004
137	Phosphorylation	PPRLHLETPQPSPQE CCCEEEECCCCCCCC	33.32	30266825
141	Phosphorylation	HLETPQPSPQEGGSV EEECCCCCCCCCCCE	33.69	30266825
147	Phosphorylation	PSPQEGGSVDIWRIP CCCCCCCCEEEEECC	27.72	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BORG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BORG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BORG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEPT7_HUMAN	SEPT7	physical	11584266
SEPT6_HUMAN	SEPT6	physical	11584266
RHOQ_HUMAN	RHOQ	physical	10490598
CDC42_HUMAN	CDC42	physical	10490598
RHG26_HUMAN	ARHGAP26	physical	25416956
NDK7_HUMAN	NME7	physical	25416956
RHG26_HUMAN	ARHGAP26	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-101 AND SER-141,AND MASS SPECTROMETRY.
PubMed: 18691976