dbPTM

BORG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BORG2_HUMAN
UniProt AC	Q9UKI2
Protein Name	Cdc42 effector protein 3
Gene Name	CDC42EP3
Organism	Homo sapiens (Human).
Sequence Length	254
Subcellular Localization	Endomembrane system Peripheral membrane protein . Cytoplasm, cytoskeleton .
Protein Description	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts..
Protein Sequence	MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPAKTPIYLKAA ---CCCCCCEEEEEC	19.61	28555341
8	Phosphorylation	MPAKTPIYLKAANNK CCCCCCEEEEECCCC	11.89	22817900
10	Methylation	AKTPIYLKAANNKKG CCCCEEEEECCCCCC	28.60	-
15	Methylation	YLKAANNKKGKKFKL EEEECCCCCCCCEEH	63.81	-
27	Phosphorylation	FKLRDILSPDMISPP EEHHHCCCHHHCCCC	21.13	26055452
32	Phosphorylation	ILSPDMISPPLGDFR CCCHHHCCCCCCCCE	17.52	26055452
41	Phosphorylation	PLGDFRHTIHIGKEG CCCCCEEEEECCCCC	15.25	29514088
57	Phosphorylation	HDVFGDISFLQGNYE CCCCCCEEEEECCEE	25.33	27642862
63	Phosphorylation	ISFLQGNYELLPGNQ EEEEECCEEECCCCH	18.12	22817900
89	Phosphorylation	NEFFRANSTSDSVFT CHHCCCCCCCCCCCC	28.44	29255136
90	Phosphorylation	EFFRANSTSDSVFTE HHCCCCCCCCCCCCC	36.04	27273156
91	Phosphorylation	FFRANSTSDSVFTET HCCCCCCCCCCCCCC	27.92	30266825
93	Phosphorylation	RANSTSDSVFTETPS CCCCCCCCCCCCCCC	20.92	30266825
96	Phosphorylation	STSDSVFTETPSPVL CCCCCCCCCCCCHHH	36.47	30266825
98	Phosphorylation	SDSVFTETPSPVLKN CCCCCCCCCCHHHCC	26.47	30266825
100	Phosphorylation	SVFTETPSPVLKNAI CCCCCCCCHHHCCCC	34.75	29255136
108	Phosphorylation	PVLKNAISLPTIGGS HHHCCCCCCCCCCCC	26.36	22617229
111	Phosphorylation	KNAISLPTIGGSQAL CCCCCCCCCCCCCCC	37.23	26657352
115	Phosphorylation	SLPTIGGSQALMLPL CCCCCCCCCCCCHHH	13.68	25850435
124	Phosphorylation	ALMLPLLSPVTFNSK CCCHHHCCCEECCCC	25.63	22199227
127	Phosphorylation	LPLLSPVTFNSKQES HHHCCCEECCCCCHH	22.08	22199227
130	Phosphorylation	LSPVTFNSKQESFGP CCCEECCCCCHHCCC	31.37	23090842
134	Phosphorylation	TFNSKQESFGPAKLP ECCCCCHHCCCCCCC	32.77	29514088
139	Ubiquitination	QESFGPAKLPRLSCE CHHCCCCCCCCCCCH	63.26	29967540
144	Phosphorylation	PAKLPRLSCEPVMEE CCCCCCCCCHHHCHH	20.08	29255136
157	Phosphorylation	EEKAQEKSSLLENGT HHHHHHHHHHHHCCC	26.01	-
164	Phosphorylation	SSLLENGTVHQGDTS HHHHHCCCEEECCCC	26.79	-
187	Phosphorylation	QSSQGRDSHSSSLSE CCCCCCCCCCCCHHH	24.73	28122231
189	Phosphorylation	SQGRDSHSSSLSEQY CCCCCCCCCCHHHHC	26.10	28122231
190	Phosphorylation	QGRDSHSSSLSEQYP CCCCCCCCCHHHHCC	29.85	28122231
191	Phosphorylation	GRDSHSSSLSEQYPD CCCCCCCCHHHHCCC	38.64	27251275
193	Phosphorylation	DSHSSSLSEQYPDWP CCCCCCHHHHCCCCC	25.30	28122231
196	Phosphorylation	SSSLSEQYPDWPAED CCCHHHHCCCCCHHH	10.10	28122231
209	Phosphorylation	EDMFDHPTPCELIKG HHCCCCCCCHHHHCC	36.83	28122231
218	Phosphorylation	CELIKGKTKSEESLS HHHHCCCCCCHHHHH	48.77	20363803
220	Phosphorylation	LIKGKTKSEESLSDL HHCCCCCCHHHHHHH	52.40	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BORG2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BORG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BORG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BORG2_HUMAN	CDC42EP3	physical	16189514
SEPT7_HUMAN	SEPT7	physical	11584266
SEPT6_HUMAN	SEPT6	physical	11584266
RHOQ_HUMAN	RHOQ	physical	10490598
CDC42_HUMAN	CDC42	physical	10490598

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BORG2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-100, AND MASSSPECTROMETRY.	17081983 [Abstract]