UniProt ID | BORG2_HUMAN | |
---|---|---|
UniProt AC | Q9UKI2 | |
Protein Name | Cdc42 effector protein 3 | |
Gene Name | CDC42EP3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 254 | |
Subcellular Localization |
Endomembrane system Peripheral membrane protein . Cytoplasm, cytoskeleton . |
|
Protein Description | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.. | |
Protein Sequence | MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Phosphorylation | ---MPAKTPIYLKAA ---CCCCCCEEEEEC | 19.61 | 28555341 | |
8 | Phosphorylation | MPAKTPIYLKAANNK CCCCCCEEEEECCCC | 11.89 | 22817900 | |
10 | Methylation | AKTPIYLKAANNKKG CCCCEEEEECCCCCC | 28.60 | - | |
15 | Methylation | YLKAANNKKGKKFKL EEEECCCCCCCCEEH | 63.81 | - | |
27 | Phosphorylation | FKLRDILSPDMISPP EEHHHCCCHHHCCCC | 21.13 | 26055452 | |
32 | Phosphorylation | ILSPDMISPPLGDFR CCCHHHCCCCCCCCE | 17.52 | 26055452 | |
41 | Phosphorylation | PLGDFRHTIHIGKEG CCCCCEEEEECCCCC | 15.25 | 29514088 | |
57 | Phosphorylation | HDVFGDISFLQGNYE CCCCCCEEEEECCEE | 25.33 | 27642862 | |
63 | Phosphorylation | ISFLQGNYELLPGNQ EEEEECCEEECCCCH | 18.12 | 22817900 | |
89 | Phosphorylation | NEFFRANSTSDSVFT CHHCCCCCCCCCCCC | 28.44 | 29255136 | |
90 | Phosphorylation | EFFRANSTSDSVFTE HHCCCCCCCCCCCCC | 36.04 | 27273156 | |
91 | Phosphorylation | FFRANSTSDSVFTET HCCCCCCCCCCCCCC | 27.92 | 30266825 | |
93 | Phosphorylation | RANSTSDSVFTETPS CCCCCCCCCCCCCCC | 20.92 | 30266825 | |
96 | Phosphorylation | STSDSVFTETPSPVL CCCCCCCCCCCCHHH | 36.47 | 30266825 | |
98 | Phosphorylation | SDSVFTETPSPVLKN CCCCCCCCCCHHHCC | 26.47 | 30266825 | |
100 | Phosphorylation | SVFTETPSPVLKNAI CCCCCCCCHHHCCCC | 34.75 | 29255136 | |
108 | Phosphorylation | PVLKNAISLPTIGGS HHHCCCCCCCCCCCC | 26.36 | 22617229 | |
111 | Phosphorylation | KNAISLPTIGGSQAL CCCCCCCCCCCCCCC | 37.23 | 26657352 | |
115 | Phosphorylation | SLPTIGGSQALMLPL CCCCCCCCCCCCHHH | 13.68 | 25850435 | |
124 | Phosphorylation | ALMLPLLSPVTFNSK CCCHHHCCCEECCCC | 25.63 | 22199227 | |
127 | Phosphorylation | LPLLSPVTFNSKQES HHHCCCEECCCCCHH | 22.08 | 22199227 | |
130 | Phosphorylation | LSPVTFNSKQESFGP CCCEECCCCCHHCCC | 31.37 | 23090842 | |
134 | Phosphorylation | TFNSKQESFGPAKLP ECCCCCHHCCCCCCC | 32.77 | 29514088 | |
139 | Ubiquitination | QESFGPAKLPRLSCE CHHCCCCCCCCCCCH | 63.26 | 29967540 | |
144 | Phosphorylation | PAKLPRLSCEPVMEE CCCCCCCCCHHHCHH | 20.08 | 29255136 | |
157 | Phosphorylation | EEKAQEKSSLLENGT HHHHHHHHHHHHCCC | 26.01 | - | |
164 | Phosphorylation | SSLLENGTVHQGDTS HHHHHCCCEEECCCC | 26.79 | - | |
187 | Phosphorylation | QSSQGRDSHSSSLSE CCCCCCCCCCCCHHH | 24.73 | 28122231 | |
189 | Phosphorylation | SQGRDSHSSSLSEQY CCCCCCCCCCHHHHC | 26.10 | 28122231 | |
190 | Phosphorylation | QGRDSHSSSLSEQYP CCCCCCCCCHHHHCC | 29.85 | 28122231 | |
191 | Phosphorylation | GRDSHSSSLSEQYPD CCCCCCCCHHHHCCC | 38.64 | 27251275 | |
193 | Phosphorylation | DSHSSSLSEQYPDWP CCCCCCHHHHCCCCC | 25.30 | 28122231 | |
196 | Phosphorylation | SSSLSEQYPDWPAED CCCHHHHCCCCCHHH | 10.10 | 28122231 | |
209 | Phosphorylation | EDMFDHPTPCELIKG HHCCCCCCCHHHHCC | 36.83 | 28122231 | |
218 | Phosphorylation | CELIKGKTKSEESLS HHHHCCCCCCHHHHH | 48.77 | 20363803 | |
220 | Phosphorylation | LIKGKTKSEESLSDL HHCCCCCCHHHHHHH | 52.40 | 20363803 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BORG2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BORG2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BORG2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
BORG2_HUMAN | CDC42EP3 | physical | 16189514 | |
SEPT7_HUMAN | SEPT7 | physical | 11584266 | |
SEPT6_HUMAN | SEPT6 | physical | 11584266 | |
RHOQ_HUMAN | RHOQ | physical | 10490598 | |
CDC42_HUMAN | CDC42 | physical | 10490598 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-100, AND MASSSPECTROMETRY. |