BORG2_HUMAN - dbPTM
BORG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BORG2_HUMAN
UniProt AC Q9UKI2
Protein Name Cdc42 effector protein 3
Gene Name CDC42EP3
Organism Homo sapiens (Human).
Sequence Length 254
Subcellular Localization Endomembrane system
Peripheral membrane protein . Cytoplasm, cytoskeleton .
Protein Description Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts..
Protein Sequence MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MPAKTPIYLKAA
---CCCCCCEEEEEC
19.6128555341
8PhosphorylationMPAKTPIYLKAANNK
CCCCCCEEEEECCCC
11.8922817900
10MethylationAKTPIYLKAANNKKG
CCCCEEEEECCCCCC
28.60-
15MethylationYLKAANNKKGKKFKL
EEEECCCCCCCCEEH
63.81-
27PhosphorylationFKLRDILSPDMISPP
EEHHHCCCHHHCCCC
21.1326055452
32PhosphorylationILSPDMISPPLGDFR
CCCHHHCCCCCCCCE
17.5226055452
41PhosphorylationPLGDFRHTIHIGKEG
CCCCCEEEEECCCCC
15.2529514088
57PhosphorylationHDVFGDISFLQGNYE
CCCCCCEEEEECCEE
25.3327642862
63PhosphorylationISFLQGNYELLPGNQ
EEEEECCEEECCCCH
18.1222817900
89PhosphorylationNEFFRANSTSDSVFT
CHHCCCCCCCCCCCC
28.4429255136
90PhosphorylationEFFRANSTSDSVFTE
HHCCCCCCCCCCCCC
36.0427273156
91PhosphorylationFFRANSTSDSVFTET
HCCCCCCCCCCCCCC
27.9230266825
93PhosphorylationRANSTSDSVFTETPS
CCCCCCCCCCCCCCC
20.9230266825
96PhosphorylationSTSDSVFTETPSPVL
CCCCCCCCCCCCHHH
36.4730266825
98PhosphorylationSDSVFTETPSPVLKN
CCCCCCCCCCHHHCC
26.4730266825
100PhosphorylationSVFTETPSPVLKNAI
CCCCCCCCHHHCCCC
34.7529255136
108PhosphorylationPVLKNAISLPTIGGS
HHHCCCCCCCCCCCC
26.3622617229
111PhosphorylationKNAISLPTIGGSQAL
CCCCCCCCCCCCCCC
37.2326657352
115PhosphorylationSLPTIGGSQALMLPL
CCCCCCCCCCCCHHH
13.6825850435
124PhosphorylationALMLPLLSPVTFNSK
CCCHHHCCCEECCCC
25.6322199227
127PhosphorylationLPLLSPVTFNSKQES
HHHCCCEECCCCCHH
22.0822199227
130PhosphorylationLSPVTFNSKQESFGP
CCCEECCCCCHHCCC
31.3723090842
134PhosphorylationTFNSKQESFGPAKLP
ECCCCCHHCCCCCCC
32.7729514088
139UbiquitinationQESFGPAKLPRLSCE
CHHCCCCCCCCCCCH
63.2629967540
144PhosphorylationPAKLPRLSCEPVMEE
CCCCCCCCCHHHCHH
20.0829255136
157PhosphorylationEEKAQEKSSLLENGT
HHHHHHHHHHHHCCC
26.01-
164PhosphorylationSSLLENGTVHQGDTS
HHHHHCCCEEECCCC
26.79-
187PhosphorylationQSSQGRDSHSSSLSE
CCCCCCCCCCCCHHH
24.7328122231
189PhosphorylationSQGRDSHSSSLSEQY
CCCCCCCCCCHHHHC
26.1028122231
190PhosphorylationQGRDSHSSSLSEQYP
CCCCCCCCCHHHHCC
29.8528122231
191PhosphorylationGRDSHSSSLSEQYPD
CCCCCCCCHHHHCCC
38.6427251275
193PhosphorylationDSHSSSLSEQYPDWP
CCCCCCHHHHCCCCC
25.3028122231
196PhosphorylationSSSLSEQYPDWPAED
CCCHHHHCCCCCHHH
10.1028122231
209PhosphorylationEDMFDHPTPCELIKG
HHCCCCCCCHHHHCC
36.8328122231
218PhosphorylationCELIKGKTKSEESLS
HHHHCCCCCCHHHHH
48.7720363803
220PhosphorylationLIKGKTKSEESLSDL
HHCCCCCCHHHHHHH
52.4020363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BORG2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BORG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BORG2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BORG2_HUMANCDC42EP3physical
16189514
SEPT7_HUMANSEPT7physical
11584266
SEPT6_HUMANSEPT6physical
11584266
RHOQ_HUMANRHOQphysical
10490598
CDC42_HUMANCDC42physical
10490598

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BORG2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-100, AND MASSSPECTROMETRY.

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