| UniProt ID | PDE6D_HUMAN | |
|---|---|---|
| UniProt AC | O43924 | |
| Protein Name | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | |
| Gene Name | PDE6D | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 150 | |
| Subcellular Localization |
Cytoplasm, cytosol . Cytoplasmic vesicle membrane Peripheral membrane protein . Cytoplasm, cytoskeleton, cilium basal body . |
|
| Protein Description | Promotes the release of prenylated target proteins from cellular membranes. [PubMed: 9712853 Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location] | |
| Protein Sequence | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Methylation | KLNWMNLRDAETGKI CCCEEECCCCCCCCE | 35.77 | 115486771 | |
| 29 | Ubiquitination | LRDAETGKILWQGTE CCCCCCCCEEEECCC | 41.88 | - | |
| 73 | Ubiquitination | SSTEQMEKFRLEQKV CCHHHHHHHCCEECE | 30.37 | - | |
| 79 | Acetylation | EKFRLEQKVYFKGQC HHHCCEECEEEECHH | 29.53 | 25953088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDE6D_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDE6D_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDE6D_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RHOB_HUMAN | RHOB | physical | 11786539 | |
| RHOA_HUMAN | RHOA | physical | 11786539 | |
| RAP1A_HUMAN | RAP1A | physical | 11786539 | |
| RAP2B_HUMAN | RAP2B | physical | 11786539 | |
| RND1_HUMAN | RND1 | physical | 11786539 | |
| RD23A_HUMAN | RAD23A | physical | 16189514 | |
| ARL2_HUMAN | ARL2 | physical | 11980706 | |
| RHEB_HUMAN | RHEB | physical | 11980706 | |
| RASH_HUMAN | HRAS | physical | 11980706 | |
| RND1_HUMAN | RND1 | physical | 11980706 | |
| RAP1A_HUMAN | RAP1A | physical | 11980706 | |
| ARL2_MOUSE | Arl2 | physical | 11980706 | |
| ARL3_MOUSE | Arl3 | physical | 11980706 | |
| RASH_HUMAN | HRAS | physical | 11786539 | |
| ARL16_HUMAN | ARL16 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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