ARL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL3_MOUSE
• UniProt AC: Q9WUL7
• Protein Name: ADP-ribosylation factor-like protein 3
• Gene Name: Arl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 182
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Detected predominantly in the
• Protein Description: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms..
• Protein Sequence: MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRSYFENTDILIYVIDSADRKRFEETGQELTELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGLLSILRK ------CCHHHHHHH	35.01	-
5	Phosphorylation	---MGLLSILRKLKS ---CCHHHHHHHHCC	25.31	27180971
11	Ubiquitination	LSILRKLKSAPDQEV HHHHHHHCCCCCHHH	47.83	-
12	Phosphorylation	SILRKLKSAPDQEVR HHHHHHCCCCCHHHE	56.31	25338131
35	Acetylation	AGKTTLLKQLASEDI CCHHHHHHHHHCCCC	46.51	22826441
43	Phosphorylation	QLASEDISHITPTQG HHHCCCCCCCCCCCC	22.59	29514104
46	Phosphorylation	SEDISHITPTQGFNI CCCCCCCCCCCCCCC	18.17	22817900
48	Phosphorylation	DISHITPTQGFNIKS CCCCCCCCCCCCCEE	32.45	29550500
54	Ubiquitination	PTQGFNIKSVQSQGF CCCCCCCEECCCCCE	45.75	-
54	Acetylation	PTQGFNIKSVQSQGF CCCCCCCEECCCCCE	45.75	22826441
62	Ubiquitination	SVQSQGFKLNVWDIG ECCCCCEEEEEEEEC	46.07	-
103	Phosphorylation	DRKRFEETGQELTEL CHHHHHHHHHHHHHH	36.65	29899451
108	Phosphorylation	EETGQELTELLEEEK HHHHHHHHHHHHHHC	24.68	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE6D_HUMAN	PDE6D	physical	10518933
PDE6D_MOUSE	Pde6d	physical	10518933

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.