SPEG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPEG_HUMAN
• UniProt AC: Q15772
• Protein Name: Striated muscle preferentially expressed protein kinase
• Gene Name: SPEG
• Organism: Homo sapiens (Human).
• Sequence Length: 3267
• Subcellular Localization: Isoform 3: Nucleus.
• Protein Description: Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells..
• Protein Sequence: MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGGGAPVAVAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDDISDVQGTQRLELRDDGAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSVPQSGLRREEPDLQPQLASEAPRRPAQPPPSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWATPGLEGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGEDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTQAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKAPEPRPEPVRASKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSLSSSIENLESEAVFEAKFKRSRESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAVGEPGLVRRLSLSLSQRLRRTPPAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQAGATTPSAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQEELGHQYVRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANRAGQGPFSNSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPSQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVSSPGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 4)	Phosphorylation	-	18.16	24719451
6	Phosphorylation	--MQKARGTRGEDAG --CCCCCCCCCCCCC	25.32	32142685
14	Phosphorylation	TRGEDAGTRAPPSPG CCCCCCCCCCCCCCC	25.94	20068231
19	Phosphorylation	AGTRAPPSPGVPPKR CCCCCCCCCCCCCCC	32.97	26437602
58	Phosphorylation	NAAVCAGSDVRLRVV CCEEECCCCEEEEEE	17.88	-
139	Phosphorylation	ETAEDDISDVQGTQR CCCCCHHHCCCCCCE	38.43	-
211	Phosphorylation	GTRRLPGSPRQAQAT CCCCCCCCHHCHHCC	18.25	30266825
218	Phosphorylation	SPRQAQATGAGPRHL CHHCHHCCCCCCCCC	18.58	23312004
234	Phosphorylation	VEPLVRASRANLVGA CHHHHHHHHHCEECC	22.74	29523821
258	Phosphorylation	VASDLYGSAFSLYRG HHHHHHHCCHHHHCC	16.75	-
261	Phosphorylation	DLYGSAFSLYRGRAL HHHHCCHHHHCCCEE	24.98	-
269	Phosphorylation	LYRGRALSIHVSVPQ HHCCCEEEEEEECCC	15.06	28348404
306	Phosphorylation	AQPPPSKSALLPPPS CCCCCCHHCCCCCCC	28.61	26437602
313	Phosphorylation	SALLPPPSPRVGKRS HCCCCCCCCCCCCCC	30.98	30266825
320	Phosphorylation	SPRVGKRSPPGPPAQ CCCCCCCCCCCCCCC	38.64	26437602
331	Phosphorylation	PPAQPAATPTSPHRR CCCCCCCCCCCCCCC	29.25	26437602
333	Phosphorylation	AQPAATPTSPHRRTQ CCCCCCCCCCCCCCC	51.00	28985074
334	Phosphorylation	QPAATPTSPHRRTQE CCCCCCCCCCCCCCC	21.66	26657352
360	Phosphorylation	KRGKKSKSSGPSLAG HCCCCCCCCCCCCCC	47.84	26437602
361	Phosphorylation	RGKKSKSSGPSLAGT CCCCCCCCCCCCCCC	59.46	27732954
364	Phosphorylation	KSKSSGPSLAGTAES CCCCCCCCCCCCCCC	34.08	26437602
368	Phosphorylation	SGPSLAGTAESRPQT CCCCCCCCCCCCCCC	22.96	26437602
371	Phosphorylation	SLAGTAESRPQTPLS CCCCCCCCCCCCCHH	46.96	27732954
375	Phosphorylation	TAESRPQTPLSEASG CCCCCCCCCHHHHHH	28.95	26657352
378	Phosphorylation	SRPQTPLSEASGRLS CCCCCCHHHHHHHHH	32.11	22673903
381	Phosphorylation	QTPLSEASGRLSALG CCCHHHHHHHHHHCC	22.01	22673903
385	Phosphorylation	SEASGRLSALGRSPR HHHHHHHHHCCCCHH	21.78	26437602
390	Phosphorylation	RLSALGRSPRLVRAG HHHHCCCCHHHHHHC	16.75	30266825
398	Phosphorylation	PRLVRAGSRILDKLQ HHHHHHCHHHHHHHH	18.37	24719451
413	Phosphorylation	FFEERRRSLERSDSP HHHHHHHHHHCCCCC	32.54	26437602
417	Phosphorylation	RRRSLERSDSPPAPL HHHHHHCCCCCCCCC	32.82	30266825
419	Phosphorylation	RSLERSDSPPAPLRP HHHHCCCCCCCCCCC	33.75	26657352
435	Phosphorylation	VPLRKARSLEQPKSE CCHHCCCCCCCCCCC	40.91	28355574
449	Phosphorylation	ERGAPWGTPGASQEE CCCCCCCCCCCCHHH	18.06	17525332
453	Phosphorylation	PWGTPGASQEELRAP CCCCCCCCHHHHCCC	44.00	17525332
462	Phosphorylation	EELRAPGSVAERRRL HHHCCCCCHHHHHHH	19.66	30266825
476	Phosphorylation	LFQQKAASLDERTRQ HHHHHHHCCCHHHHH	41.01	30266825
481	Phosphorylation	AASLDERTRQRSPAS HHCCCHHHHHCCCCH	29.16	23403867
485	Phosphorylation	DERTRQRSPASDLEL CHHHHHCCCCHHHHH	19.24	30266825
488	Phosphorylation	TRQRSPASDLELRFA HHHCCCCHHHHHHHH	46.22	30266825
504	Phosphorylation	ELGRIRRSTSREELV HHHHHHCCCCHHHHH	22.38	27732954
505	Phosphorylation	LGRIRRSTSREELVR HHHHHCCCCHHHHHH	29.96	27732954
506	Phosphorylation	GRIRRSTSREELVRS HHHHCCCCHHHHHHC	38.65	27732954
513	Phosphorylation	SREELVRSHESLRAT CHHHHHHCHHHHHHH	24.91	29523821
516	Phosphorylation	ELVRSHESLRATLQR HHHHCHHHHHHHHHC	20.10	26437602
526	Phosphorylation	ATLQRAPSPREPGEP HHHHCCCCCCCCCCC	35.29	22496350
537	Phosphorylation	PGEPPLFSRPSTPKT CCCCCCCCCCCCCCC	51.47	30266825
540	Phosphorylation	PPLFSRPSTPKTSRA CCCCCCCCCCCCCCC	57.12	30266825
541	Phosphorylation	PLFSRPSTPKTSRAV CCCCCCCCCCCCCCC	31.33	30266825
549	Phosphorylation	PKTSRAVSPAAAQPP CCCCCCCCHHHCCCC	14.08	30266825
557	Phosphorylation	PAAAQPPSPSSAEKP HHHCCCCCCCCCCCC	44.06	30266825
559	Phosphorylation	AAQPPSPSSAEKPGD HCCCCCCCCCCCCCC	46.66	30266825
560	Phosphorylation	AQPPSPSSAEKPGDE CCCCCCCCCCCCCCC	43.78	30266825
563	Acetylation	PSPSSAEKPGDEPGR CCCCCCCCCCCCCCC	54.76	7663181
599	Phosphorylation	RRDQFPLTRSRAIQE HHHCCCCCHHHHHHH	27.17	18187866
609	Phosphorylation	RAIQECRSPVPPPAA HHHHHHCCCCCCCCC	41.74	26437602
623	Phosphorylation	ADPPEARTKAPPGRK CCCHHHCCCCCCCCC	38.31	24719451
847	Phosphorylation	PGETWPRTPTMKPSP CCCCCCCCCCCCCCC	21.02	26437602
849	Phosphorylation	ETWPRTPTMKPSPSQ CCCCCCCCCCCCCCC	36.89	27732954
853	Phosphorylation	RTPTMKPSPSQNRRS CCCCCCCCCCCCCCC	31.50	28188228
855	Phosphorylation	PTMKPSPSQNRRSSD CCCCCCCCCCCCCCC	44.41	23927012
861	Phosphorylation	PSQNRRSSDTGSKAP CCCCCCCCCCCCCCC	37.06	24719451
1039	Phosphorylation	HEDDSGVYTCKLSTA CCCCCCEEEEECEEC	15.22	29116813
1067	Phosphorylation	PSLAPLFTRLLEDVE HHHHHHHHHHHHCHH	28.26	22617229
1128	Phosphorylation	LHIAHVGSEDEGLYA EEEEECCCCCCCEEE	40.56	-
1172	Phosphorylation	SKLEKMPSIPEEPEQ HHHHCCCCCCCCCCC	47.48	26657352
1532	Phosphorylation	LTESSHVSFVYEENE EECCCCEEEEECCCC	11.99	30576142
1546	Phosphorylation	ECSLVVLSTGAQDGG CEEEEEECCCCCCCC	17.12	30576142
1567	Phosphorylation	QNLAGEVSCKAELAV CCCCCCCCEEEEEHH	12.95	30576142
1598	Phosphorylation	DHRGRRLSDFYDIHQ CCCCCCHHHHHHHHH	24.70	22673903
1823	Phosphorylation	FEETTFLSLSREARG EEECCCHHHCHHHHH	21.80	24719451
1825	Phosphorylation	ETTFLSLSREARGFL ECCCHHHCHHHHHHH	25.38	17081983
1880	O-linked_Glycosylation	SRRRWQRSQISYKCH HHHHHHHHHHHHEEC	19.43	29351928
1981	Phosphorylation	QEQGRAPSQDQEAPS HHCCCCCCCCCCCCC	45.46	26437602
1988	Phosphorylation	SQDQEAPSPEALPSP CCCCCCCCCCCCCCC	42.28	22673903
1994	Phosphorylation	PSPEALPSPGQEPAA CCCCCCCCCCCCCCC	42.38	22673903
2004	Phosphorylation	QEPAAGASPRRGELR CCCCCCCCCCCCCCC	20.30	24719451
2014	Phosphorylation	RGELRRGSSAESALP CCCCCCCCCHHHCCC	25.27	26657352
2015	Phosphorylation	GELRRGSSAESALPR CCCCCCCCHHHCCCC	38.59	22777824
2018	Phosphorylation	RRGSSAESALPRAGP CCCCCHHHCCCCCCH	34.52	24719451
2037	Phosphorylation	RGLHKAASVELPQRR CCCHHHCCCCCCCCC	22.45	30266825
2045	Phosphorylation	VELPQRRSPSPGATR CCCCCCCCCCCCCCH	31.73	26437602
2047	Phosphorylation	LPQRRSPSPGATRLA CCCCCCCCCCCCHHH	36.89	26437602
2051	Phosphorylation	RSPSPGATRLARGGL CCCCCCCCHHHCCCC	31.93	22673903
2055	Asymmetric dimethylarginine	PGATRLARGGLGEGE CCCCHHHCCCCCCCH	44.28	-
2055	Methylation	PGATRLARGGLGEGE CCCCHHHCCCCCCCH	44.28	30989429
2083	Acetylation	RGGPEDGKVSGLRGP HCCCCCCCCCCCCHH	45.62	133827
2085	Phosphorylation	GPEDGKVSGLRGPLL CCCCCCCCCCCHHHH	35.28	26437602
2109	Phosphorylation	PRMARAASSEAAPHH HHHHHHHCCCCCCCC	27.94	26657352
2110	Phosphorylation	RMARAASSEAAPHHQ HHHHHHCCCCCCCCC	26.91	26657352
2128	Phosphorylation	ENRGLQKSSSFSQGE CCCCCCCCCCCCCCC	20.46	19764811
2129	Phosphorylation	NRGLQKSSSFSQGEA CCCCCCCCCCCCCCC	42.30	19764811
2130	Phosphorylation	RGLQKSSSFSQGEAE CCCCCCCCCCCCCCC	35.69	28355574
2139	Methylation	SQGEAEPRGRHRRAG CCCCCCCCCCCCCCC	46.40	-
2164	Phosphorylation	GARRLQESPSLSALS HHHHHHCCCCHHHHH	13.56	22673903
2166	Phosphorylation	RRLQESPSLSALSEA HHHHCCCCHHHHHCC	44.21	26437602
2168	Phosphorylation	LQESPSLSALSEAQP HHCCCCHHHHHCCCC	31.34	22673903
2171	Phosphorylation	SPSLSALSEAQPSSP CCCHHHHHCCCCCCC	30.51	22673903
2176	Phosphorylation	ALSEAQPSSPARPSA HHHCCCCCCCCCCCC	36.55	22673903
2177	Phosphorylation	LSEAQPSSPARPSAP HHCCCCCCCCCCCCC	29.30	22673903
2187	Phosphorylation	RPSAPKPSTPKSAEP CCCCCCCCCCCCCCC	64.57	23312004
2188	Phosphorylation	PSAPKPSTPKSAEPS CCCCCCCCCCCCCCC	43.17	23312004
2284	Phosphorylation	AVFARVASPPPGAPE EEEEEECCCCCCCCC	34.77	26437602
2296	Phosphorylation	APEKRVPSAGGPPVL CCCCCCCCCCCCCCC	36.37	26437602
2311	Phosphorylation	AEKARVPTVPPRPGS CCCCCCCCCCCCCCC	42.67	23312004
2318	Phosphorylation	TVPPRPGSSLSSSIE CCCCCCCCCCHHHHH	30.68	26437602
2322	Phosphorylation	RPGSSLSSSIENLES CCCCCCHHHHHHHHC	40.40	26437602
2323	Phosphorylation	PGSSLSSSIENLESE CCCCCHHHHHHHHCH	30.46	26437602
2340	Phosphorylation	FEAKFKRSRESPLSL HHHHHCCCCCCCHHH	40.78	26437602
2343	Phosphorylation	KFKRSRESPLSLGLR HHCCCCCCCHHHHHH	29.99	24719451
2355	Phosphorylation	GLRLLSRSRSEERGP HHHHHHCCCCCCCCC	36.46	26437602
2357	Phosphorylation	RLLSRSRSEERGPFR HHHHCCCCCCCCCCC	45.09	26437602
2376	Phosphorylation	EDGIYRPSPAGTPLE CCCCCCCCCCCCCHH	20.55	-
2380	Phosphorylation	YRPSPAGTPLELVRR CCCCCCCCCHHHHCC	27.14	-
2391	Phosphorylation	LVRRPERSRSVQDLR HHCCCCCCCCHHHHH	27.52	26437602
2393	Phosphorylation	RRPERSRSVQDLRAV CCCCCCCCHHHHHHH	25.94	23312004
2410	Phosphorylation	PGLVRRLSLSLSQRL CHHHHHHHHCHHHHH	17.69	26657352
2412	Phosphorylation	LVRRLSLSLSQRLRR HHHHHHHCHHHHHHC	23.69	26437602
2414	Phosphorylation	RRLSLSLSQRLRRTP HHHHHCHHHHHHCCC	15.18	23312004
2420	Phosphorylation	LSQRLRRTPPAQRHP HHHHHHCCCHHHCCC	27.47	26437602
2438	Phosphorylation	ARGGDGESSEGGSSA CCCCCCCCCCCCCCC	38.94	-
2439	Phosphorylation	RGGDGESSEGGSSAR CCCCCCCCCCCCCCC	35.64	-
2443	Phosphorylation	GESSEGGSSARGSPV CCCCCCCCCCCCCCC	31.51	22673903
2444	Phosphorylation	ESSEGGSSARGSPVL CCCCCCCCCCCCCCH	25.84	22673903
2448	Phosphorylation	GGSSARGSPVLAMRR CCCCCCCCCCHHHHH	13.29	30266825
2458	Phosphorylation	LAMRRRLSFTLERLS HHHHHHHHHHHHHHH	17.86	19764811
2460	Phosphorylation	MRRRLSFTLERLSSR HHHHHHHHHHHHHHH	25.08	22673903
2466	Phosphorylation	FTLERLSSRLQRSGS HHHHHHHHHHHHCCC	41.42	28634298
2471	Phosphorylation	LSSRLQRSGSSEDSG HHHHHHHCCCCCCCC	30.02	-
2484	Phosphorylation	SGGASGRSTPLFGRL CCCCCCCCCCCCHHH	37.59	26437602
2495	Phosphorylation	FGRLRRATSEGESLR CHHHHHHCCCCHHHH	26.04	26437602
2496	Phosphorylation	GRLRRATSEGESLRR HHHHHHCCCCHHHHH	42.49	26437602
2500	Phosphorylation	RATSEGESLRRLGLP HHCCCCHHHHHHCCC	37.72	26437602
2518	Phosphorylation	LAAQAGATTPSAESL HHHHCCCCCCCHHHH	38.02	-
2521	Phosphorylation	QAGATTPSAESLGSE HCCCCCCCHHHHCCC	42.44	-
2524	Phosphorylation	ATTPSAESLGSEASA CCCCCHHHHCCCCCC	37.43	-
2559	Phosphorylation	PRKDKGLSPPNLSAS CCCCCCCCCCCCCHH	47.16	-
2566	Phosphorylation	SPPNLSASVQEELGH CCCCCCHHHHHHHCC	22.43	26437602
2643	Phosphorylation	KDGRQLLSIPRAGKR CCCCEEEECCCCCCC	38.86	23403867
2658	Phosphorylation	HAGLYECSATNVLGS CCEEEECCCCCCHHH	26.62	-
2710	Phosphorylation	SRAPCTYTLERRVDG CCCCCEEEEEEECCC	12.18	23532336
2762	Phosphorylation	GQGPFSNSSEKVFVR CCCCCCCCCCEEEEE	38.38	26437602
2771	Phosphorylation	EKVFVRGTQDSSAVP CEEEEECCCCCCCCC	20.73	-
2774	Phosphorylation	FVRGTQDSSAVPSAA EEECCCCCCCCCCHH	15.47	-
2775	Phosphorylation	VRGTQDSSAVPSAAH EECCCCCCCCCCHHC	41.39	25954137
2799	Phosphorylation	ARARPPDSPTSLAPP CCCCCCCCCCCCCCC	35.53	27251275
2801	Phosphorylation	ARPPDSPTSLAPPLA CCCCCCCCCCCCCCC	40.08	26437602
2802	Phosphorylation	RPPDSPTSLAPPLAP CCCCCCCCCCCCCCC	26.39	27251275
2813	Phosphorylation	PLAPAAPTPPSVTVS CCCCCCCCCCCCEEC	43.00	29449344
2816	Phosphorylation	PAAPTPPSVTVSPSS CCCCCCCCCEECCCC	31.46	27251275
2818	Phosphorylation	APTPPSVTVSPSSPP CCCCCCCEECCCCCC	21.43	27251275
2820	Phosphorylation	TPPSVTVSPSSPPTP CCCCCEECCCCCCCC	15.08	27251275
2822	Phosphorylation	PSVTVSPSSPPTPPS CCCEECCCCCCCCHH	48.23	27251275
2823	Phosphorylation	SVTVSPSSPPTPPSQ CCEECCCCCCCCHHH	37.98	27251275
2826	Phosphorylation	VSPSSPPTPPSQALS ECCCCCCCCHHHHHH	51.74	27251275
2829	Phosphorylation	SSPPTPPSQALSSLK CCCCCCHHHHHHHCC	29.32	27251275
2833	Phosphorylation	TPPSQALSSLKAVGP CCHHHHHHHCCCCCC	36.32	24719451
2834	Phosphorylation	PPSQALSSLKAVGPP CHHHHHHHCCCCCCC	34.44	27251275
2844	Phosphorylation	AVGPPPQTPPRRHRG CCCCCCCCCCCCCCC	40.82	26657352
2931	Phosphorylation	PTKVTVQSLSPAKEV CCEEEEEECCCCCEE	26.86	30266825
2933	Phosphorylation	KVTVQSLSPAKEVVS EEEEEECCCCCEEEC	28.23	30266825
2940	Phosphorylation	SPAKEVVSSPGSSPR CCCCEEECCCCCCCC	35.67	22673903
2941	Phosphorylation	PAKEVVSSPGSSPRS CCCEEECCCCCCCCC	22.98	26437602
2944	Phosphorylation	EVVSSPGSSPRSSPR EEECCCCCCCCCCCC	40.32	26437602
2945	Phosphorylation	VVSSPGSSPRSSPRP EECCCCCCCCCCCCC	30.19	26437602
2948	Phosphorylation	SPGSSPRSSPRPEGT CCCCCCCCCCCCCCC	48.34	26437602
2949	Phosphorylation	PGSSPRSSPRPEGTT CCCCCCCCCCCCCCC	26.63	17081983
2955	Phosphorylation	SSPRPEGTTLRQGPP CCCCCCCCCCCCCCC	22.46	26437602
2956	Phosphorylation	SPRPEGTTLRQGPPQ CCCCCCCCCCCCCCC	30.69	22673903
3122	Phosphorylation	LRPLGHRTGTLEFMA CCCCCCCCCCEEEEC	28.92	22210691
3151	Phosphorylation	IWGAGVLTYIMLSGR HCCHHHHHHHHCCCC	14.48	22210691
3156	Phosphorylation	VLTYIMLSGRSPFYE HHHHHHCCCCCCCCC	18.12	22210691
3254	Phosphorylation	RRRAEAATRHKVLLR HHHHHHHHHHHHHHH	40.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPEG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPEG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPEG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615959: Myopathy, centronuclear, 5 (CNM5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-449 AND SER-453, ANDMASS SPECTROMETRY.
PubMed: 17525332

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-599, AND MASSSPECTROMETRY.
PubMed: 18187866