HMCS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMCS2_HUMAN
• UniProt AC: P54868
• Protein Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
• Gene Name: HMGCS2
• Organism: Homo sapiens (Human).
• Sequence Length: 508
• Subcellular Localization: Mitochondrion.
• Protein Description: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase..
• Protein Sequence: MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	PVAHQRFSTASAVPL HHHHHCCCCCCCCCC	25.83	26657352
38	Phosphorylation	VAHQRFSTASAVPLA HHHHCCCCCCCCCCC	23.17	24275569
52	Succinylation	AKTDTWPKDVGILAL CCCCCCCCCCCEEEE	57.52	-
52	Succinylation	AKTDTWPKDVGILAL CCCCCCCCCCCEEEE	57.52	-
76	Phosphorylation	DQTDLEKYNNVEAGK CHHHHHHHCCCCCCC	11.55	-
83	Acetylation	YNNVEAGKYTVGLGQ HCCCCCCCEEEECCC	44.81	20167786
83	Succinylation	YNNVEAGKYTVGLGQ HCCCCCCCEEEECCC	44.81	-
83	Succinylation	YNNVEAGKYTVGLGQ HCCCCCCCEEEECCC	44.81	-
97	Phosphorylation	QTRMGFCSVQEDINS CCCCCCCCHHHHHHH	25.28	28258704
131	Phosphorylation	VGRLEVGTETIIDKS CCCEEECCEEECCHH	34.82	23401153
133	Phosphorylation	RLEVGTETIIDKSKA CEEECCEEECCHHHH	24.07	24275569
137	Ubiquitination	GTETIIDKSKAVKTV CCEEECCHHHHHHHH	43.37	21906983
137	Acetylation	GTETIIDKSKAVKTV CCEEECCHHHHHHHH	43.37	25953088
166	S-palmitoylation	GIDTTNACYGGTASL CCCCCCCCCCCHHHH	3.35	20124434
221	Succinylation	VAMLIGPKAPLALER EEHHHCCCCCHHHHC	58.38	-
221	Succinylation	VAMLIGPKAPLALER EEHHHCCCCCHHHHC	58.38	-
239	Phosphorylation	GTHMENVYDFYKPNL CCCCCHHHHHCCCCC	16.36	-
243	Acetylation	ENVYDFYKPNLASEY CHHHHHCCCCCCCCC	27.68	-
248	Phosphorylation	FYKPNLASEYPIVDG HCCCCCCCCCCEECC	40.61	-
250	Phosphorylation	KPNLASEYPIVDGKL CCCCCCCCCEECCEE	8.86	21253578
256	Acetylation	EYPIVDGKLSIQCYL CCCEECCEEEHHHHH	34.30	24889763
256	Succinylation	EYPIVDGKLSIQCYL CCCEECCEEEHHHHH	34.30	-
256	Succinylation	EYPIVDGKLSIQCYL CCCEECCEEEHHHHH	34.30	-
262	Phosphorylation	GKLSIQCYLRALDRC CEEEHHHHHHHHHHH	5.26	-
276	Trimethylation	CYTSYRKKIQNQWKQ HHHHHHHHHHHHHHH	40.29	-
276	Methylation	CYTSYRKKIQNQWKQ HHHHHHHHHHHHHHH	40.29	23644510
305	S-nitrosylation	MIFHTPFCKMVQKSL HHHCCHHHHHHHHHH	2.68	25040305
305	S-palmitoylation	MIFHTPFCKMVQKSL HHHCCHHHHHHHHHH	2.68	20124434
306	Acetylation	IFHTPFCKMVQKSLA HHCCHHHHHHHHHHH	42.35	-
310	Succinylation	PFCKMVQKSLARLMF HHHHHHHHHHHHHHH	35.71	-
310	Acetylation	PFCKMVQKSLARLMF HHHHHHHHHHHHHHH	35.71	2401891
310	Succinylation	PFCKMVQKSLARLMF HHHHHHHHHHHHHHH	35.71	-
322	Phosphorylation	LMFNDFLSASSDTQT HHHHHHHCCCCCCHH	26.54	21406692
324	Phosphorylation	FNDFLSASSDTQTSL HHHHHCCCCCCHHHH	25.93	21406692
325	Phosphorylation	NDFLSASSDTQTSLY HHHHCCCCCCHHHHH	44.38	21406692
327	Phosphorylation	FLSASSDTQTSLYKG HHCCCCCCHHHHHHH	35.38	21406692
329	Phosphorylation	SASSDTQTSLYKGLE CCCCCCHHHHHHHHH	23.85	21406692
330	Phosphorylation	ASSDTQTSLYKGLEA CCCCCHHHHHHHHHH	21.64	21406692
332	Phosphorylation	SDTQTSLYKGLEAFG CCCHHHHHHHHHHCC	11.63	21406692
333	Succinylation	DTQTSLYKGLEAFGG CCHHHHHHHHHHCCC	63.41	-
333	Succinylation	DTQTSLYKGLEAFGG CCHHHHHHHHHHCCC	63.41	-
342	Succinylation	LEAFGGLKLEDTYTN HHHCCCCCCEECCCC	53.78	-
342	Succinylation	LEAFGGLKLEDTYTN HHHCCCCCCEECCCC	53.78	-
342	Acetylation	LEAFGGLKLEDTYTN HHHCCCCCCEECCCC	53.78	-
346	Phosphorylation	GGLKLEDTYTNKDLD CCCCCEECCCCCHHH	23.91	23312004
347	Phosphorylation	GLKLEDTYTNKDLDK CCCCEECCCCCHHHH	22.19	23312004
348	Phosphorylation	LKLEDTYTNKDLDKA CCCEECCCCCHHHHH	37.57	23312004
350	Acetylation	LEDTYTNKDLDKALL CEECCCCCHHHHHHH	52.44	27178108
350	Succinylation	LEDTYTNKDLDKALL CEECCCCCHHHHHHH	52.44	-
350	Succinylation	LEDTYTNKDLDKALL CEECCCCCHHHHHHH	52.44	-
354	Succinylation	YTNKDLDKALLKASQ CCCCHHHHHHHHHCH	48.51	-
354	Succinylation	YTNKDLDKALLKASQ CCCCHHHHHHHHHCH	48.51	-
354	Acetylation	YTNKDLDKALLKASQ CCCCHHHHHHHHHCH	48.51	27178108
358	Succinylation	DLDKALLKASQDMFD HHHHHHHHHCHHHHC	47.01	-
358	Succinylation	DLDKALLKASQDMFD HHHHHHHHHCHHHHC	47.01	-
358	Acetylation	DLDKALLKASQDMFD HHHHHHHHHCHHHHC	47.01	27178108
366	Acetylation	ASQDMFDKKTKASLY HCHHHHCHHHCEEEE	51.59	27178108
367	Acetylation	SQDMFDKKTKASLYL CHHHHCHHHCEEEEE	58.04	7666167
398	Phosphorylation	ASLLSHHSAQELAGS HHHHCCCCHHHHCCC	26.65	-
414	Phosphorylation	IGAFSYGSGLAASFF CCEEECCCCCHHHHH	23.54	-
419	Phosphorylation	YGSGLAASFFSFRVS CCCCCHHHHHEEEEC	22.63	-
422	Phosphorylation	GLAASFFSFRVSQDA CCHHHHHEEEECCCC	15.33	24719451
426	Phosphorylation	SFFSFRVSQDAAPGS HHHEEEECCCCCCCC	20.34	22798277
433	Phosphorylation	SQDAAPGSPLDKLVS CCCCCCCCCHHHHHH	22.64	26657352
437	Acetylation	APGSPLDKLVSSTSD CCCCCHHHHHHCCCC	59.48	-
440	Phosphorylation	SPLDKLVSSTSDLPK CCHHHHHHCCCCCCH	38.03	22798277
441	Phosphorylation	PLDKLVSSTSDLPKR CHHHHHHCCCCCCHH	25.17	25072903
442	Phosphorylation	LDKLVSSTSDLPKRL HHHHHHCCCCCCHHH	20.82	25072903
443	Phosphorylation	DKLVSSTSDLPKRLA HHHHHCCCCCCHHHH	38.81	25072903
447	Succinylation	SSTSDLPKRLASRKC HCCCCCCHHHHCCCC	68.30	-
447	Succinylation	SSTSDLPKRLASRKC HCCCCCCHHHHCCCC	68.30	-
447	Acetylation	SSTSDLPKRLASRKC HCCCCCCHHHHCCCC	68.30	2380825
456	Phosphorylation	LASRKCVSPEEFTEI HHCCCCCCHHHHHHH	35.74	28348404
473	Succinylation	QREQFYHKVNFSPPG HHHHHHHHCCCCCCC	27.74	-
473	Succinylation	QREQFYHKVNFSPPG HHHHHHHHCCCCCCC	27.74	-
473	Acetylation	QREQFYHKVNFSPPG HHHHHHHHCCCCCCC	27.74	2380229
477	Phosphorylation	FYHKVNFSPPGDTNS HHHHCCCCCCCCCCC	25.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMCS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
83	K	Succinylation	Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.	-
310	K	Succinylation	Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMCS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605911: HMG-CoA synthase deficiency (HMGCS deficiency)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.