PANK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PANK1_HUMAN
• UniProt AC: Q8TE04
• Protein Name: Pantothenate kinase 1
• Gene Name: PANK1
• Organism: Homo sapiens (Human).
• Sequence Length: 598
• Subcellular Localization: Cytoplasm .
• Protein Description: Plays a role in the physiological regulation of the intracellular CoA concentration..
• Protein Sequence: MLKLVGGGGGQDWACSVAGTSLGGEEAAFEVARPGDQGKAGGGSPGWGCAGIPDSAPGAGVLQAGAVGPARGGQGAEEVGESAGGGEERRVRHPQAPALRLLNRKPQGGSGEIKTPENDLQRGRLSRGPRTAPPAPGMGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPPHVCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	GEEAAFEVARPGDQG CCEEEEEEECCCCCC	4.41	22817900
35	Ubiquitination	AFEVARPGDQGKAGG EEEEECCCCCCCCCC	34.03	22817900
42	Ubiquitination	GDQGKAGGGSPGWGC CCCCCCCCCCCCCCC	37.96	22817900
44	Ubiquitination	QGKAGGGSPGWGCAG CCCCCCCCCCCCCCC	24.42	22817900
46	Ubiquitination	KAGGGSPGWGCAGIP CCCCCCCCCCCCCCC	34.80	22817900
48	Ubiquitination	GGGSPGWGCAGIPDS CCCCCCCCCCCCCCC	9.41	22817900
50	Ubiquitination	GSPGWGCAGIPDSAP CCCCCCCCCCCCCCC	18.27	22817900
61	Ubiquitination	DSAPGAGVLQAGAVG CCCCCCCEECCCCCC	3.38	22817900
65	Ubiquitination	GAGVLQAGAVGPARG CCCEECCCCCCCCCC	14.08	22817900
73	Ubiquitination	AVGPARGGQGAEEVG CCCCCCCCCCHHHHH	19.73	22817900
77	Ubiquitination	ARGGQGAEEVGESAG CCCCCCHHHHHHCCC	61.10	22817900
110	Phosphorylation	NRKPQGGSGEIKTPE CCCCCCCCCCCCCCH	39.83	23532336
152	Phosphorylation	QERSVPHSPGAPVGT CCCCCCCCCCCCCCH	20.96	28348404
211 (in isoform 3)	Phosphorylation	-	36.82	-
215	Phosphorylation	PLLPQHDSPAKKCRL CCCCCCCCHHHHHHH	25.32	23401153
218 (in isoform 3)	Phosphorylation	-	56.65	-
228	Phosphorylation	RLRRRMDSGRKNRPP HHHHCCCCCCCCCCC	31.02	24275569
251	Ubiquitination	GGTLVKLVYFEPKDI CCEEEEEEEECCCCC	4.22	29967540
252	Phosphorylation	GTLVKLVYFEPKDIT CEEEEEEEECCCCCC	16.80	29496907
271	Ubiquitination	QEEVENLKSIRKYLT HHHHHHHHHHHHHHH	56.25	22817900
275	Ubiquitination	ENLKSIRKYLTSNTA HHHHHHHHHHHCCCC	42.83	22817900
276	Phosphorylation	NLKSIRKYLTSNTAY HHHHHHHHHHCCCCC	12.83	19835603
278	Phosphorylation	KSIRKYLTSNTAYGK HHHHHHHHCCCCCCC	19.48	19835603
285	Ubiquitination	TSNTAYGKTGIRDVH HCCCCCCCCCCCEEE	30.79	-
304	Ubiquitination	NLTMCGRKGNLHFIR CCEECCCCCCEEEEE	37.12	-
314	Phosphorylation	LHFIRFPSCAMHRFI EEEEECCHHHHHHHH	16.28	-
420	Phosphorylation	VNMGSGVSILAVYSK EECCCCEEEEEEEEC	18.53	-
425	Phosphorylation	GVSILAVYSKDNYKR CEEEEEEEECCCCEE	12.37	-
430	Phosphorylation	AVYSKDNYKRVTGTS EEEECCCCEECEEEE	15.42	-
451	Phosphorylation	LGLCCLLTGCETFEE HHHHHHHHCCCCHHH	27.17	-
455	Phosphorylation	CLLTGCETFEEALEM HHHHCCCCHHHHHHH	40.18	-
476	Ubiquitination	TNVDKLVKDIYGGDY CCHHHHHHHHHCCCH	49.17	29967540
508	Phosphorylation	MSKEKRDSISKEDLA CCHHHHHCCCHHHHH	32.56	28176443
510	Phosphorylation	KEKRDSISKEDLARA HHHHHCCCHHHHHHH	33.66	28111955
511	Ubiquitination	EKRDSISKEDLARAT HHHHCCCHHHHHHHH	54.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PANK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PANK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PANK1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PANK1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.