UNC79_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNC79_HUMAN
• UniProt AC: Q9P2D8
• Protein Name: Protein unc-79 homolog
• Gene Name: UNC79
• Organism: Homo sapiens (Human).
• Sequence Length: 2635
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability..
• Protein Sequence: MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDILSTLPYTMISTLATFPPFLHKDIIEYLSTSFLPMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERIAGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGAAAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNADFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVINQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSSVQEQALLWLHVLSELDIMVPLQLLISMFSDGVNSVKELANQRKSRVSELAGNLASRRVSVASDPGRRVQHNMLSPFHSPFQSPFRSPLRSPFRSPFKNFGHPGGRTIDFDCEDDEMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHTCQKDEKAIECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSSRPEFIIGPEGEEEENPASKHGENPGNCTEPVEHAAVKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYIARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPVESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMAKDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDISKILLHLIHITVNTLNAQYHSCKPHATAGPLYSDNSNISRYSEKEKGEIELAEYRETGALQDSLLHCVREESIPKKKLRSFKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIEKPPTQAAYIAQRPNDPGRSRQNSATRPDNSEIPENPAMEGFPDARRPVIPEVRLNCMETFEVKVDSPVKPAPKEDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEEETMNQGDDGPSGKNAASSPSVPSHPSVLSLSTAPLVQVSVEDCSKDFSSKDSGNNQSAGNTDSALITLEDPMDAEGSSKPEELPEFSCGSPLTLKQKRDLLQKSFALPEMSLDDHPDPGTEGEKPGELMPSSGAKTVLLKVPEDAENPTESEKPDTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPDPSTKGLSTLEMPRESSSAPTLDAGVPETSSHSSISTQYRQMKRGSLGVLTMSQLMKRQLEHQSSAPHNISNWDTEQIQPGKRQCNVPTCLNPDLEGQPLRMRGATKSSLLSAPSIVSMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSTIKDGTFLRTLASSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECVRQYINEVLDFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMDISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHVADHLIVILIGFPEQSKTSVLHMCSLFHAFIFAQLWTVYCEQSAVATNLQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNIKHLSAGLQLRLQAIQNHVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	DIANTLKYFSQTLLS HHHHHHHHHHHHHHH	16.15	-
43	Phosphorylation	ANTLKYFSQTLLSIL HHHHHHHHHHHHHHH	21.11	-
48	Phosphorylation	YFSQTLLSILSRTGK HHHHHHHHHHHHHCC	25.29	24719451
51	Phosphorylation	QTLLSILSRTGKKEN HHHHHHHHHHCCCCC	26.57	24719451
82	Phosphorylation	VPFPLTPSLRPQVSS CCCCCCHHHCCCHHC	31.60	24719451
257	Phosphorylation	YKQEVWKDLLYVIAY HCHHHHHHHCHHHHH	26.62	27251275
434	Phosphorylation	TSPPPINTRECGAEE CCCCCCCCCCCCHHH	28.68	27251275
451	Phosphorylation	CAVEAVISLLKEAEF HHHHHHHHHHHHHHH	22.50	24719451
476	Phosphorylation	RRRQLGLSSSHHSLD HHHHHCCCCCCCCCC	28.17	24706070
478	Phosphorylation	RQLGLSSSHHSLDNA HHHCCCCCCCCCCCC	23.11	24706070
513	Phosphorylation	WFLVSLCTPSENTPT HHHHHCCCCCCCCCH	34.83	22210691
515	Phosphorylation	LVSLCTPSENTPTES HHHCCCCCCCCCHHH	25.89	22210691
518	Phosphorylation	LCTPSENTPTESLAR CCCCCCCCCHHHHHH	27.77	22210691
550	Phosphorylation	DEVGSLVEKLKPQFV HHHHHHHHHHCHHHH	58.95	20068231
724	Phosphorylation	ELANQRKSRVSELAG HHHHHHHHHHHHHHH	39.85	23403867
727	Phosphorylation	NQRKSRVSELAGNLA HHHHHHHHHHHHHHH	26.28	20068231
735	Phosphorylation	ELAGNLASRRVSVAS HHHHHHHHCCEECCC	24.64	20068231
754	Phosphorylation	RVQHNMLSPFHSPFQ CCCCCCCCCCCCCCC	18.10	-
758	Phosphorylation	NMLSPFHSPFQSPFR CCCCCCCCCCCCCCC	27.99	-
820	Phosphorylation	ELQDDGITMGLEHSL CCCCCCCCCCCHHHC	15.66	22210691
826	Phosphorylation	ITMGLEHSLSKDIIS CCCCCHHHCCHHHHH	25.59	22210691
833	Phosphorylation	SLSKDIISIINNVFQ HCCHHHHHHHHHHHC	20.11	22210691
899	Phosphorylation	SLEDSLLSSRPEFII CHHHHHHHCCCCEEE	29.60	24719451
900	Phosphorylation	LEDSLLSSRPEFIIG HHHHHHHCCCCEEEC	52.39	24719451
1011	Phosphorylation	QDHMLIASLWRVVKS HHHHHHHHHHHHHHH	22.82	24719451
1223	Phosphorylation	FARNRQKSVRSLRDS HHHHHHHHHHHHHHH	17.90	-
1230	Phosphorylation	SVRSLRDSVKGPVES HHHHHHHHCCCCHHC	21.21	-
1242	Phosphorylation	VESKRALSLPETLTS HHCHHHHCCCHHHHH	40.67	24076635
1248 (in isoform 3)	Phosphorylation	-	35.08	22210691
1249 (in isoform 3)	Phosphorylation	-	29.24	22210691
1256 (in isoform 3)	Phosphorylation	-	39.82	22210691
1294	Phosphorylation	FMAKDESSAESDISS HHHCCCCCCCCCHHH	33.73	-
1301	Phosphorylation	SAESDISSAKAFNTV CCCCCHHHHHHHHHH	33.84	28555341
1307	Phosphorylation	SSAKAFNTVKRHLYV HHHHHHHHHHHHHHH	22.43	-
1877	Phosphorylation	DPSTKGLSTLEMPRE CCCCCCCCCCCCCCC	39.35	29396449
1915	Phosphorylation	YRQMKRGSLGVLTMS HHHHHCCCHHHHHHH	26.44	-
1922	Phosphorylation	SLGVLTMSQLMKRQL CHHHHHHHHHHHHHH	18.22	-
2261	Phosphorylation	DKFYLSRSVVLELLQ CCHHHCHHHHHHHHH	17.13	-
2299	Phosphorylation	AGTKLAESTILSKQM CCCHHHHHHHHCHHH	18.36	22210691
2300	Phosphorylation	GTKLAESTILSKQMI CCHHHHHHHHCHHHH	19.90	22210691
2324	Phosphorylation	AMECVRQYINEVLDF HHHHHHHHHHHHHHH	8.64	24043423
2337	Phosphorylation	DFMADMHTLTKLKSH HHHHHHHHHHHHHHH	29.50	22210691
2339	Phosphorylation	MADMHTLTKLKSHMK HHHHHHHHHHHHHHC	35.17	22210691
2423	Phosphorylation	SWLLLGSLTHNAVCP HHHHHCCCCCCCCCC	5.54	20068231
2540	Phosphorylation	MVCLHVISLMEALQE HHHHHHHHHHHHHHH	22.15	22468782
2593	Phosphorylation	VNHHSLRTLPGSGQS CCCCCCCCCCCCCCC	42.47	20068231
2597	Phosphorylation	SLRTLPGSGQSSAGL CCCCCCCCCCCHHHH	31.55	20068231
2600	Phosphorylation	TLPGSGQSSAGLAAL CCCCCCCCHHHHHHH	26.19	20068231
2601	Phosphorylation	LPGSGQSSAGLAALR CCCCCCCHHHHHHHH	20.61	24667141
2614	Phosphorylation	LRKWLQCTQFKMAQV HHHHHHCCCCEEEEE	24.87	-
2625	Phosphorylation	MAQVEIQSSEAASQF EEEEEECCCHHHHHC	35.49	22210691
2626	Phosphorylation	AQVEIQSSEAASQFY EEEEECCCHHHHHCC	18.19	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNC79_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNC79_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNC79_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of UNC79_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.