UCP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCP3_HUMAN
• UniProt AC: P55916
• Protein Name: Mitochondrial uncoupling protein 3
• Gene Name: UCP3
• Organism: Homo sapiens (Human).
• Sequence Length: 312
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance..
• Protein Sequence: MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	AGLQRQMSFASIRIG HHHHHHHCCHHEEEE	14.88	30622161
93	Phosphorylation	QRQMSFASIRIGLYD HHHHCCHHEEEECCC	15.47	30622161
99	Phosphorylation	ASIRIGLYDSVKQVY HHEEEECCCCCCEEE	10.85	30622161
101	O-linked_Glycosylation	IRIGLYDSVKQVYTP EEEECCCCCCEEECC	20.05	30379171
101	Phosphorylation	IRIGLYDSVKQVYTP EEEECCCCCCEEECC	20.05	30622161
106	Phosphorylation	YDSVKQVYTPKGADN CCCCCEEECCCCCCC	18.16	30622161
107	Phosphorylation	DSVKQVYTPKGADNS CCCCEEECCCCCCCC	21.48	30622161
166	Phosphorylation	YSGTMDAYRTIAREE CCCCHHHHHHHHHHH	12.20	-
168	Phosphorylation	GTMDAYRTIAREEGV CCHHHHHHHHHHHCC	13.30	-
270	Phosphorylation	MVAQEGPTAFYKGFT HHHCCCCCEECCCCC	40.01	-
310	Phosphorylation	KVQMLRESPF----- HHHHHHCCCC-----	25.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433B_HUMAN	YWHAB	physical	10785390
1433Z_HUMAN	YWHAZ	physical	10785390
1433T_HUMAN	YWHAQ	physical	10785390

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.