BANK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BANK1_HUMAN
• UniProt AC: Q8NDB2
• Protein Name: B-cell scaffold protein with ankyrin repeats
• Gene Name: BANK1
• Organism: Homo sapiens (Human).
• Sequence Length: 785
• Protein Description: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2..
• Protein Sequence: MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	APGKGLGSPDPAPCG CCCCCCCCCCCCCCC	31.04	28060719
25 (in isoform 4)	Phosphorylation	-	50.13	22210691
28 (in isoform 4)	Phosphorylation	-	33.34	22210691
35 (in isoform 4)	Phosphorylation	-	45.62	22210691
66	Phosphorylation	LYRLENFSFRHLELL HHCCCCCCCCHHHHH	32.71	24719451
107	Phosphorylation	FLEKILHSPKSVVTL HHHHHHCCCCHHHHH	30.49	24719451
119	Ubiquitination	VTLLCGVKSSDQLYE HHHHHCCCCHHHHHH	29.53	-
148	Phosphorylation	QEPEDYISVIQSIIF CCCCHHHHHHHHHHC	13.62	-
161	Phosphorylation	IFKDSEDYFEVNIPT HCCCCCCCEEEECCC	9.51	23532336
175	Phosphorylation	TDLRAKHSGEISERK CCHHHHHCCCCCCHH	37.10	28348404
295	Phosphorylation	CLFRMADSGESLCQN HHHHHCCCCCHHHHH	34.62	28270605
298	Phosphorylation	RMADSGESLCQNSIE HHCCCCCHHHHHCHH	37.66	28270605
303	Phosphorylation	GESLCQNSIEELDGV CCHHHHHCHHHHHHH	12.90	28270605
313	Phosphorylation	ELDGVLTSIFKHEIP HHHHHHHHHHCCCCC	23.13	24719451
542	Phosphorylation	VEGQMERSQNWGHPG EEECHHHCCCCCCCC	17.98	28348404
605	Phosphorylation	KKKTGSRSFIINRPP EECCCCCEEEECCCC	23.61	26657352
615	Phosphorylation	INRPPAPTPRPTSIP ECCCCCCCCCCCCCC	33.75	23312004
630	Phosphorylation	PKEETTPYIAQVFQQ CCCCCCHHHHHHHHH	13.54	22817900
663	Phosphorylation	QDRARIESPAFSTLR CCHHHCCCCHHHHHH	21.11	21955146
667	Phosphorylation	RIESPAFSTLRGCLT HCCCCHHHHHHHHCC	28.74	21955146
668	Phosphorylation	IESPAFSTLRGCLTD CCCCHHHHHHHHCCC	17.64	21955146
737	Phosphorylation	RPEEENVYNKLTIVH CCHHHCCCCCEEEEE	20.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BANK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BANK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
66	Phosphorylation	61 (5)	R ⇒ H;L	rs10516487	Systemic lupus erythematosus	18204447 26502338

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LYN_HUMAN	LYN	physical	11782428
ITPR1_HUMAN	ITPR1	physical	11782428

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 152700: Systemic lupus erythematosus (SLE)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.