AN18A_HUMAN - dbPTM
AN18A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AN18A_HUMAN
UniProt AC Q8IVF6
Protein Name Ankyrin repeat domain-containing protein 18A
Gene Name ANKRD18A
Organism Homo sapiens (Human).
Sequence Length 992
Subcellular Localization
Protein Description
Protein Sequence MRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPTSNPQTSNNCKNFLTEVLLC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
169PhosphorylationALNKEGNTPLLFAIN
HHHCCCCCCEEEEEC		26.60-
256UbiquitinationRQQILEHKNKMLKNH
HHHHHHHHHHHHHHH		49.2227667366
261UbiquitinationEHKNKMLKNHLRNDN
HHHHHHHHHHHCCCC		38.5329967540
325PhosphorylationGKKKDAMYGNFMLKK
CCHHHHHHHHHHHHH		15.6169212527
345UbiquitinationKEELYAIKNDSLRKE
HHHHHHHHCCHHHHH		46.6729967540
348PhosphorylationLYAIKNDSLRKEKKY
HHHHHCCHHHHHHHH		39.1926091039
354UbiquitinationDSLRKEKKYIQEIKS
CHHHHHHHHHHHHHH		48.9929967540
371UbiquitinationEINANFEKSVRLNEK
HHCCCHHHHCCCCHH		50.5429967540
395UbiquitinationSQQLNDLKAENARLN
HHHHHHHHHHHHHHH		57.4229967540
403PhosphorylationAENARLNSELEKEKH
HHHHHHHHHHHHHHH		48.4210519007
407UbiquitinationRLNSELEKEKHNKER
HHHHHHHHHHHHHHH		82.0329967540
416UbiquitinationKHNKERLEAEVESLH
HHHHHHHHHHHHHHH		49.3429967540
433UbiquitinationLATAINEYNEIVERK
HHHHHHHHHHHHHHC		17.3829967540
457UbiquitinationDDVSRHEKMGSNISQ
HHHHHHHHHCCCHHH		42.3029967540
468UbiquitinationNISQLTDKNELLTEQ
CHHHHCCHHHHHHHH		47.2729967540
530UbiquitinationQMHPNGEAKESQSIG
HHCCCCCCCHHHCCC		23.4729967540
538UbiquitinationKESQSIGKQNSLEER
CHHHCCCCCCCHHHH		44.6421906983
541PhosphorylationQSIGKQNSLEERIRQ
HCCCCCCCHHHHHHH		34.3628122231
585UbiquitinationRDCLENGKEDLLEER
HHHHHCCCHHHHHHH		60.6929967540
600UbiquitinationNKELMKEYNYLKEKL
HHHHHHHHHHHHHHH		12.0029967540
645PhosphorylationSESPLEGTSHCHINL
CCCCCCCCCCCEEEC		13.11-
645UbiquitinationSESPLEGTSHCHINL
CCCCCCCCCCCEEEC		13.1121906983
647UbiquitinationSPLEGTSHCHINLNE
CCCCCCCCCEEECCC		13.6529967540
689PhosphorylationLISLLNYTADQIRKK
HHHHHHHCHHHHHHH		23.7646163983
757UbiquitinationFNDLVAEKEAVSSEC
HHHHHHHHHHHCHHH		41.0329967540
819UbiquitinationDMVELGKLQEYKSEL
HHHHHHHHHHHHHHC		4.4329967540
823UbiquitinationLGKLQEYKSELDERA
HHHHHHHHHHCHHHH		36.382190698
844UbiquitinationLEEIHLQKQAEYEKQ
HHHHHHHHHHHHHHH		58.8129967540
869PhosphorylationSLKKKELTLKDVECK
HHHHHCCCHHHHHHH		32.62772371001
871UbiquitinationKKKELTLKDVECKFS
HHHCCCHHHHHHHHH		55.2629967540
906UbiquitinationAGAVKANNSMSKKLM
HHHHHCCCHHHHHHH		43.9029967540
915PhosphorylationMSKKLMKSDKKIAVI
HHHHHHCCCCCEEEE		40.4723403867
930UbiquitinationSTKLFTEKQRMKYFL
EECCCCHHHHHHHHH		39.9021906983
933UbiquitinationLFTEKQRMKYFLSTL
CCCHHHHHHHHHHCC		3.7029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AN18A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AN18A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AN18A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TTC33_HUMANTTC33physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AN18A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-869, AND MASSSPECTROMETRY.

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