SETBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SETBP_HUMAN
• UniProt AC: Q9Y6X0
• Protein Name: SET-binding protein
• Gene Name: SETBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1596
• Subcellular Localization: Nucleus .
• Protein Sequence: MESRETLSSSRQRGGESDFLPVSSAKPPAAPGCAGEPLLSTPGPGKGIPVGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSGDQKVSRAGKNSKATKEEERSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSTLHYDTGLPQDFTGDTLKPKHQQKSSSQNHMDWSTNSDSGPVTQNCFISPESGRETASTSKIPALEPVASFAKAQGKKGSAGNTWSQLSNNNKDLLLGGVAPSPSSHSSPAPPSSSAECNGLQPLVDQDGGGTKEPPEPPTVGSKKKSSKKDVISQTIPNPDLDWVKNAQKAFDNTEGKREGYSADSAQEASPARQNVSSASNPENDSSHVRITIPIKAPSLDPTNHKRKKRQSIKAVVEKIMPEKALASGITMSSEVVNRILSNSEGNKKDPRVPKLSKMIENESPSVGLETGGNAEKVIPGGVSKPRKPPMVMTPPTCTDHSPSRKLPEIQHPKFAAKRRWTCSKPKPSTMLREAVMATSDKLMLEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSVALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNFQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPPPQFHTNSHVKMSGAAKHKAKHGVHLQGPVSMGLGDMQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRILGTHDNLSGLFAGKATGFSSHILSERLSSADKELPLVSEKNKHKEKQKHQHSEAGHKASKNNFEVDTLSTLSLSDAQHWTQAKEKGDLSSEPVDSCTKRYSGSGGDGGSTRSENLDVFSEMNPSNDKWDSDVSGSKRRSYEGFGTYREKDIQAFKMNRKERSSYDSSMSPGMPSPHLKVDQTAVHSKNEGSVPTMMTRKKPAAVDSVTIPPAPVLSLLAASAATSDAVGSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPLPPPPPLPKTPRGGKRKHKPQAPAQPPQQSPPQQPLPQEEEVKAKRQRKSRGSESEVLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESRETLSSS -----CCCHHHHHHH	47.47	24114839
6	Phosphorylation	--MESRETLSSSRQR --CCCHHHHHHHHHC	30.72	24114839
6	O-linked_Glycosylation	--MESRETLSSSRQR --CCCHHHHHHHHHC	30.72	30379171
8	Phosphorylation	MESRETLSSSRQRGG CCCHHHHHHHHHCCC	33.42	24114839
9	Phosphorylation	ESRETLSSSRQRGGE CCHHHHHHHHHCCCC	32.43	24114839
10	Phosphorylation	SRETLSSSRQRGGES CHHHHHHHHHCCCCC	29.11	24043423
92	Phosphorylation	GLEEQEFSIKEANFT CCCCCEEEEEECCCC	31.81	24719451
132	Phosphorylation	CPPEIKITIKQSGDQ CCCCCEEEEEECCCH	19.67	24719451
140	Acetylation	IKQSGDQKVSRAGKN EEECCCHHHHCCCCC	47.09	7364715
146	Acetylation	QKVSRAGKNSKATKE HHHHCCCCCCCCCHH	58.00	7364725
172	Phosphorylation	TASDLAASDLKGFQP HHHHHHHHHCCCCCC	37.56	-
259	Phosphorylation	PALEPVASFAKAQGK CCHHHHHHHHHHCCC	26.43	28060719
273	Phosphorylation	KKGSAGNTWSQLSNN CCCCCCCHHHHHHHC	26.10	-
381	Phosphorylation	ADSAQEASPARQNVS CCHHHHCCCCCCCCC	20.52	28348404
403	Phosphorylation	DSSHVRITIPIKAPS CCCCEEEEEEEECCC	15.33	24719451
439	Phosphorylation	MPEKALASGITMSSE CCHHHHHCCCCCCHH	31.42	-
453	Phosphorylation	EVVNRILSNSEGNKK HHHHHHHHCCCCCCC	35.62	22210691
508	Phosphorylation	PMVMTPPTCTDHSPS CCCCCCCCCCCCCCC	29.28	28348404
510	Phosphorylation	VMTPPTCTDHSPSRK CCCCCCCCCCCCCCC	38.94	28348404
513	Phosphorylation	PPTCTDHSPSRKLPE CCCCCCCCCCCCCCC	27.64	28348404
565	Phosphorylation	PPSAYPITPSSPLYT CCCCCCCCCCCCCCC	16.77	28348404
567	Phosphorylation	SAYPITPSSPLYTNT CCCCCCCCCCCCCCC	35.62	28348404
568	Phosphorylation	AYPITPSSPLYTNTD CCCCCCCCCCCCCCC	21.81	28348404
571	Phosphorylation	ITPSSPLYTNTDSLT CCCCCCCCCCCCCEE	11.00	28348404
572	Phosphorylation	TPSSPLYTNTDSLTV CCCCCCCCCCCCEEE	39.05	28348404
574	Phosphorylation	SSPLYTNTDSLTVIT CCCCCCCCCCEEEEE	21.11	28348404
576	Phosphorylation	PLYTNTDSLTVITPV CCCCCCCCEEEEECC	24.73	28348404
581	Phosphorylation	TDSLTVITPVKKKRG CCCEEEEECCCCCCC	20.07	-
611	Phosphorylation	GTSTSPVSPISREFP CCCCCCCCCCCCCCC	21.65	27251275
614	Phosphorylation	TSPVSPISREFPGTK CCCCCCCCCCCCCCH	29.19	17081983
683	Phosphorylation	NILNQILSCSSSVAL HHHHHHHHCCCHHHH	17.37	27174698
685	Phosphorylation	LNQILSCSSSVALKA HHHHHHCCCHHHHHC	23.44	27174698
686	Phosphorylation	NQILSCSSSVALKAK HHHHHCCCHHHHHCC	32.91	27174698
687	Phosphorylation	QILSCSSSVALKAKA HHHHCCCHHHHHCCC	8.63	27174698
720	Phosphorylation	INVSKRGTIYIGKKR EEECCCCEEEECCCC	18.03	-
725	Methylation	RGTIYIGKKRGRKPR CCEEEECCCCCCCCC	29.73	-
817	Acetylation	PISALPTKTQKGIHS CCCCCCCCCCCCCCC	47.20	-
818	Phosphorylation	ISALPTKTQKGIHSG CCCCCCCCCCCCCCC	37.68	26552605
824	Phosphorylation	KTQKGIHSGTWKLSP CCCCCCCCCCCCCCC	35.68	26552605
826	Phosphorylation	QKGIHSGTWKLSPPR CCCCCCCCCCCCCCC	23.57	27251275
830	Phosphorylation	HSGTWKLSPPRLMAN CCCCCCCCCCCHHCC	29.18	26552605
838	Phosphorylation	PPRLMANSPSHLCEI CCCHHCCCHHHEEEE	20.45	28348404
840	Phosphorylation	RLMANSPSHLCEIGS CHHCCCHHHEEEECC	28.98	32142685
893	Phosphorylation	SESRRRYSFDFCSLD HHHHHHHEEEEECCC	19.27	28348404
898	Phosphorylation	RYSFDFCSLDNPEAI HHEEEEECCCCCCCC	38.46	22210691
910	Phosphorylation	EAIPSDTSTKNRHGH CCCCCCCCCCCCCCC	42.23	22210691
911	Phosphorylation	AIPSDTSTKNRHGHR CCCCCCCCCCCCCCC	34.14	22210691
993	Phosphorylation	FRINFDHYYPVPYIQ EEEECCCCCCCCCEE	16.00	26552605
994	Phosphorylation	RINFDHYYPVPYIQY EEECCCCCCCCCEEC	8.37	26552605
998	Phosphorylation	DHYYPVPYIQYDPLL CCCCCCCCEECCCHH	10.82	26552605
1001	Phosphorylation	YPVPYIQYDPLLYLR CCCCCEECCCHHHHH	15.23	26552605
1006	Phosphorylation	IQYDPLLYLRRTSDL EECCCHHHHHCHHHC	13.07	26552605
1024	"N6,N6-dimethyllysine"	KKRGRPAKTNDTMTK HHCCCCCCCCCCCCC	51.01	-
1024	Methylation	KKRGRPAKTNDTMTK HHCCCCCCCCCCCCC	51.01	-
1039	Phosphorylation	VPFLQGFSYPIPSGS CCCCCCCCCCCCCCC	36.50	-
1040	Phosphorylation	PFLQGFSYPIPSGSY CCCCCCCCCCCCCCC	11.70	-
1192	Phosphorylation	ILSERLSSADKELPL HHHHHHHHCCCCCCC	45.11	24719451
1201	Phosphorylation	DKELPLVSEKNKHKE CCCCCCCCCCHHHHH	51.00	24719451
1263	Phosphorylation	VDSCTKRYSGSGGDG CCCCCCCCCCCCCCC	20.95	19690332
1264	Phosphorylation	DSCTKRYSGSGGDGG CCCCCCCCCCCCCCC	30.43	19690332
1266	Phosphorylation	CTKRYSGSGGDGGST CCCCCCCCCCCCCCC	33.39	19690332
1272	Phosphorylation	GSGGDGGSTRSENLD CCCCCCCCCCCCCCC	26.61	19690332
1273	Phosphorylation	SGGDGGSTRSENLDV CCCCCCCCCCCCCCC	41.30	-
1298	Phosphorylation	WDSDVSGSKRRSYEG CCCCCCCCCCCCCCC	18.58	-
1354	Phosphorylation	VHSKNEGSVPTMMTR ECCCCCCCCCCCCCC	20.81	22210691
1379	Phosphorylation	IPPAPVLSLLAASAA CCCHHHHHHHHHHHH	22.90	25332170
1384	Phosphorylation	VLSLLAASAATSDAV HHHHHHHHHHCCHHH	16.90	25332170
1387	Phosphorylation	LLAASAATSDAVGSS HHHHHHHCCHHHHHH	27.19	25332170
1394	Phosphorylation	TSDAVGSSLKKRFKR CCHHHHHHHHHHHHH	37.98	-
1417	Phosphorylation	EVRKMCNYTKILSTK HHHHHHCHHHHHCCC	12.41	28060719
1418	Phosphorylation	VRKMCNYTKILSTKK HHHHHCHHHHHCCCC	9.53	28060719
1422	Phosphorylation	CNYTKILSTKKNLDH HCHHHHHCCCCCHHH	41.47	24719451
1432	Ubiquitination	KNLDHVNKILKAKRL CCHHHHHHHHHHHHH	48.61	-
1445	Phosphorylation	RLQRQSKTGNNFVKK HHHHHCCCCCCHHHH	50.84	-
1451	Acetylation	KTGNNFVKKRRGRPR CCCCCHHHHHCCCCC	36.10	30585821
1452	Acetylation	TGNNFVKKRRGRPRK CCCCHHHHHCCCCCC	41.86	30585827
1483	Phosphorylation	EKCIDLPSKRGQKPS HHHHCCCCCCCCCCC	42.13	24719451
1484	Acetylation	KCIDLPSKRGQKPSL HHHCCCCCCCCCCCC	59.62	7823431
1587	Phosphorylation	KAKRQRKSRGSESEV HHHHHHHHCCCCCCC	44.02	27251275
1590	Phosphorylation	RQRKSRGSESEVLP- HHHHHCCCCCCCCC-	36.52	27251275
1592	Phosphorylation	RKSRGSESEVLP--- HHHCCCCCCCCC---	34.40	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SETBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SETBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SETBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SET_HUMAN	SET	physical	11231286
A4_HUMAN	APP	physical	21832049
PP2AA_HUMAN	PPP2CA	physical	25306901
SETBP_HUMAN	SETBP1	physical	25416956
SPNXA_HUMAN	SPANXA1	physical	25416956
LCHN_HUMAN	KIAA1147	physical	25416956
SPNXD_HUMAN	SPANXD	physical	25416956
SPNXC_HUMAN	SPANXC	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 269150: Schinzel-Giedion midface retraction syndrome (SGMFS)
• 23832012). Myeloid malignancies are separated into three main categories: Note=SETBP1 somatic mutations are frequently found in myeloid malignancies. They cause gain of function associated with myeloid leukemic transformation (PubMed
• 614286:
• 616078: Mental retardation, autosomal dominant 29 (MRD29)
• 601626: Leukemia, acute myelogenous (AML)
• 608232: Leukemia, chronic myeloid, atypical (ACML)
• 607785: Leukemia, juvenile myelomonocytic (JMML)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-687, AND MASSSPECTROMETRY.
PubMed: 18187866