FOXL2_HUMAN - dbPTM
FOXL2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOXL2_HUMAN
UniProt AC P58012
Protein Name Forkhead box protein L2
Gene Name FOXL2
Organism Homo sapiens (Human).
Sequence Length 376
Subcellular Localization Nucleus .
Protein Description Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2..
Protein Sequence MMASYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MMASYPEPEDA
----CCCCCCCHHHC		24.2722022399
5Phosphorylation---MMASYPEPEDAA
---CCCCCCCHHHCH		11.3222022399
25SumoylationPETGRTVKEPEGPPP
CCCCCCCCCCCCCCC		67.92-
25SumoylationPETGRTVKEPEGPPP
CCCCCCCCCCCCCCC		67.92-
33PhosphorylationEPEGPPPSPGKGGGG
CCCCCCCCCCCCCCC		52.6512529855
76PhosphorylationESAEKRLTLSGIYQY
HHHHHHCCHHHHHHH		23.9427174698
78PhosphorylationAEKRLTLSGIYQYII
HHHHCCHHHHHHHHH		20.2227174698
81PhosphorylationRLTLSGIYQYIIAKF
HCCHHHHHHHHHHHC		9.9727174698
83PhosphorylationTLSGIYQYIIAKFPF
CHHHHHHHHHHHCCC		4.1927174698
91PhosphorylationIIAKFPFYEKNKKGW
HHHHCCCHHCCCCCH		26.65-
96UbiquitinationPFYEKNKKGWQNSIR
CCHHCCCCCHHHHHH		74.83-
96AcetylationPFYEKNKKGWQNSIR
CCHHCCCCCHHHHHH		74.8343395613
101PhosphorylationNKKGWQNSIRHNLSL
CCCCHHHHHHHCCCC		13.1027251275
107PhosphorylationNSIRHNLSLNECFIK
HHHHHCCCCCCEEEE		34.1720873877
114SumoylationSLNECFIKVPREGGG
CCCCEEEEECCCCCC		26.40-
114SumoylationSLNECFIKVPREGGG
CCCCEEEEECCCCCC		26.40-
127PhosphorylationGGERKGNYWTLDPAC
CCCCCCCEEECCHHH		14.4022817900
140AcetylationACEDMFEKGNYRRRR
HHHHHHHCCCHHHHH		40.9943395615
150SumoylationYRRRRRMKRPFRPPP
HHHHHHCCCCCCCCC		55.92-
186PhosphorylationAGAGADGYGYLAPPK
CCCCCCCCCCCCCCH		11.8027642862
211PhosphorylationWPLPQPPSPMPYASC
CCCCCCCCCCCHHHH		40.2822022399
215PhosphorylationQPPSPMPYASCQMAA
CCCCCCCHHHHHHHH		12.6122022399
238PhosphorylationAAAAGPGSPGAAAVV
HHHHCCCCHHHHHHH		24.2422022399
258PhosphorylationPAASYGPYTRVQSMA
CCHHHCCCCCHHCCC		11.6522817900
263PhosphorylationGPYTRVQSMALPPGV
CCCCCHHCCCCCCCC		11.8112560069
323PhosphorylationAPPPGQLSPASPATA
CCCCCCCCCCCCCCC		15.5522022399
326PhosphorylationPGQLSPASPATAAPP
CCCCCCCCCCCCCCC		20.6022022399
329PhosphorylationLSPASPATAAPPAPA
CCCCCCCCCCCCCCC		27.0822022399
366AcetylationSYWDHDSKTGALHSR
CCCCCCCCCCCCCCC		57.9743395617
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
33SPhosphorylationKinaseGSK3BP49841
PSP
263SPhosphorylationKinasePAK1Q13153
PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOXL2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOXL2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMAD3_HUMANSMAD3physical
19106105
UBC9_HUMANUBE2Iphysical
19744555
LATS1_HUMANLATS1physical
20407010
DX39A_HUMANDDX39Aphysical
25609649
HNRL2_HUMANHNRNPUL2physical
25609649
NSMA3_HUMANSMPD4physical
25609649
SYYC_HUMANYARSphysical
25609649
BTAF1_HUMANBTAF1physical
25609649
NSDHL_HUMANNSDHLphysical
25609649
PDS5A_HUMANPDS5Aphysical
25609649
SYVC_HUMANVARSphysical
25609649
ACSL4_HUMANACSL4physical
25609649
AN32C_HUMANANP32Cphysical
25609649
DCNL5_HUMANDCUN1D5physical
25609649
FUBP3_HUMANFUBP3physical
25609649
HXK2_HUMANHK2physical
25609649
SYIC_HUMANIARSphysical
25609649
NU205_HUMANNUP205physical
25609649
P4HA1_HUMANP4HA1physical
25609649
SIX1_HUMANSIX1physical
25609649
SMC2_HUMANSMC2physical
25609649
UBE4A_HUMANUBE4Aphysical
25609649
LARP1_HUMANLARP1physical
25609649
CMS1_HUMANCMSS1physical
25609649
MOV10_HUMANMOV10physical
25609649
NKRF_HUMANNKRFphysical
25609649
LARP7_HUMANLARP7physical
25609649
POP1_HUMANPOP1physical
25609649
PMGT2_HUMANPOMGNT2physical
25609649
TAP26_HUMANCCDC59physical
25609649
DDX52_HUMANDDX52physical
25609649
PUF60_HUMANPUF60physical
25609649
TRM2A_HUMANTRMT2Aphysical
25609649
SYDM_HUMANDARS2physical
25609649
DHX16_HUMANDHX16physical
25609649
DNJC9_HUMANDNAJC9physical
25609649
FIP1_HUMANFIP1L1physical
25609649
G45IP_HUMANGADD45GIP1physical
25609649
RM21_HUMANMRPL21physical
25609649
RM24_HUMANMRPL24physical
25609649
RM03_HUMANMRPL3physical
25609649
RT18A_HUMANMRPS18Aphysical
25609649
GLYR1_HUMANGLYR1physical
25609649
NSUN4_HUMANNSUN4physical
25609649
PESC_HUMANPES1physical
25609649
RBMX_HUMANRBMXphysical
25609649
RECQ4_HUMANRECQL4physical
25609649
RTCA_HUMANRTCAphysical
25609649
SUGP2_HUMANSUGP2physical
25609649
SRPK2_HUMANSRPK2physical
25609649
TR150_HUMANTHRAP3physical
25609649
TTF1_HUMANTTF1physical
25609649
TTF2_HUMANTTF2physical
25609649
ZFR_HUMANZFRphysical
25609649
CXXC5_HUMANCXXC5physical
22544055
CREM_HUMANCREMphysical
22544055
GMEB1_HUMANGMEB1physical
22544055
NR2C1_HUMANNR2C1physical
22544055
SP100_HUMANSP100physical
22544055
RLA1_HUMANRPLP1physical
22544055
BAF_HUMANBANF1physical
22544055
XRCC6_HUMANXRCC6physical
22544055
SIR1_HUMANSIRT1physical
22544055
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
110100Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES)
608996Premature ovarian failure 3 (POF3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOXL2_HUMAN

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Related Literatures of Post-Translational Modification
Sumoylation
ReferencePubMed
"Sumoylation of forkhead L2 by Ubc9 is required for its activity as atranscriptional repressor of the Steroidogenic Acute Regulatorygene.";
Kuo F.T., Bentsi-Barnes I.K., Barlow G.M., Bae J., Pisarska M.D.;
Cell. Signal. 21:1935-1944(2009).
Cited for: FUNCTION AS TRANSCRIPTIONAL REPRESSOR OF STAR, INTERACTION WITH UBE2I,SUMOYLATION AT LYS-25, SUBCELLULAR LOCATION, AND MUTAGENESIS OFLYS-25.

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