NOX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOX5_HUMAN
• UniProt AC: Q96PH1
• Protein Name: NADPH oxidase 5
• Gene Name: NOX5
• Organism: Homo sapiens (Human).
• Sequence Length: 765
• Subcellular Localization: Membrane ; Multi-pass membrane protein .; Isoform v2: Endoplasmic reticulum.; Isoform v5: Endoplasmic reticulum.
• Protein Description: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin..
• Protein Sequence: MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	ARWLRWVTQQFKTIA HHHHHHHHHHHHHHC	15.08	22673903
37	Phosphorylation	WVTQQFKTIAGEDGE HHHHHHHHHCCCCCC	19.83	22673903
46	Phosphorylation	AGEDGEISLQEFKAA CCCCCCEEHHHHHHH	21.50	22673903
441	Phosphorylation	KAIGLAVSRMAAVCI HHHHHHHHHHHHHHH	15.67	21955146
456	Phosphorylation	MEVNLLPSKVTHLLI HHHCCCCHHHHHHHH	39.46	24719451
521	Phosphorylation	WTNRLYESFKASDPL HHHHHHHHHHCCCCC	20.63	-
536	Phosphorylation	GRGSKRLSRSVTMRK CCCCCCCCHHHHCCH	26.92	-
540	Phosphorylation	KRLSRSVTMRKSQRS CCCCHHHHCCHHHCC	16.71	-
544	Phosphorylation	RSVTMRKSQRSSKGS HHHHCCHHHCCCCCC	22.06	-
548	Phosphorylation	MRKSQRSSKGSEILL CCHHHCCCCCCCHHH	43.13	-
651	Phosphorylation	RSFEWFVSLLTKLEM CCHHHHHHHHHHHCC	14.26	24719451
705	Phosphorylation	ANKEKKDSITGLQTR HCCCCCCCCCCCCCC	30.81	-
721	Phosphorylation	QPGRPDWSKVFQKVA CCCCCCHHHHHHHHH	26.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:23023377

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP74_HUMAN	HSPA4	physical	23023377
HS90A_HUMAN	HSP90AA1	physical	23023377
CHIP_HUMAN	STUB1	physical	23023377
MTHR_HUMAN	MTHFR	physical	28514442
GCYB1_HUMAN	GUCY1B3	physical	28514442
PDP2_HUMAN	PDP2	physical	28514442
TTC4_HUMAN	TTC4	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
KAP1_HUMAN	PRKAR1B	physical	28514442
STIP1_HUMAN	STIP1	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.