dbPTM

CSEN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSEN_HUMAN
UniProt AC	Q9Y2W7
Protein Name	Calsenilin
Gene Name	KCNIP3
Organism	Homo sapiens (Human).
Sequence Length	256
Subcellular Localization	Cytoplasm . Cell membrane Lipid-anchor. Endoplasmic reticulum . Golgi apparatus . Nucleus . Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. Th
Protein Description	Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation..
Protein Sequence	MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MQPAKEVTKASDGSL CCCCHHCCCCCCCCC	23.22	22115753
11	Phosphorylation	AKEVTKASDGSLLGD CHHCCCCCCCCCCCC	44.02	22115753
14	Phosphorylation	VTKASDGSLLGDLGH CCCCCCCCCCCCCCC	25.97	22115753
22	Phosphorylation	LLGDLGHTPLSKKEG CCCCCCCCCCCHHCC	24.91	26091039
25	Phosphorylation	DLGHTPLSKKEGIKW CCCCCCCCHHCCCCC	42.77	22115753
26	Sumoylation	LGHTPLSKKEGIKWQ CCCCCCCHHCCCCCC	63.63	-
26	Sumoylation	LGHTPLSKKEGIKWQ CCCCCCCHHCCCCCC	63.63	21070824
45	S-palmitoylation	SRQALMRCCLVKWIL HHHHHHHHHHHHHHH	1.00	-
46	S-palmitoylation	RQALMRCCLVKWILS HHHHHHHHHHHHHHH	3.27	-
60	Phosphorylation	SSTAPQGSDSSDSEL HCCCCCCCCCCCCCE	29.13	-
63	Phosphorylation	APQGSDSSDSELELS CCCCCCCCCCCEEHH	50.58	16112838
86	Phosphorylation	LDQLQAQTKFTKKEL HHHHHHHCCCCHHHH	31.01	29083192
89	Phosphorylation	LQAQTKFTKKELQSL HHHHCCCCHHHHHHH	42.64	29083192
90	Sumoylation	QAQTKFTKKELQSLY HHHCCCCHHHHHHHH	47.59	21070824
90	Sumoylation	QAQTKFTKKELQSLY HHHCCCCHHHHHHHH	47.59	-
95	Phosphorylation	FTKKELQSLYRGFKN CCHHHHHHHHHHHCC	39.74	17102134
156	Phosphorylation	EDFVVGLSILLRGTV HHHHHHHHHHHHCCH	12.78	24719451
174	Phosphorylation	LKWAFNLYDINKDGY HHHHHHHCCCCCCCC	18.84	-
241	Sumoylation	EFLEACQKDENIMSS HHHHHHHCCCCHHHH	67.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
63	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
63	S	Phosphorylation	Kinase	CK1-FAMILY	-	GPS
63	S	Phosphorylation	Kinase	CK1	-	Uniprot
95	S	Phosphorylation	Kinase	GRK2	P25098	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
63	S	Phosphorylation		12837631
Phosphorylation at Ser-63 inhibits cleavage by CASP3.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSEN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD177_HUMAN	CD177	physical	16189514
PSN2_HUMAN	PSEN2	physical	9771752
PSN1_HUMAN	PSEN1	physical	9771752
CREM_HUMAN	CREM	physical	11094064
PSN1_HUMAN	PSEN1	physical	10854253
CREB1_HUMAN	CREB1	physical	12198160
PHS2_HUMAN	PCBD2	physical	20211142
UBC9_HUMAN	UBE2I	physical	21070824
GRK6_HUMAN	GRK6	physical	17102134
ARBK1_HUMAN	ADRBK1	physical	17102134
CSEN_HUMAN	KCNIP3	physical	17102134
CLN3_HUMAN	CLN3	physical	17189291
KCND2_HUMAN	KCND2	physical	23692269
CD177_HUMAN	CD177	physical	25416956
MAVS_HUMAN	MAVS	physical	25416956
CTBP1_HUMAN	CTBP1	physical	16787403
CTBP2_HUMAN	CTBP2	physical	16787403

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSEN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation of calsenilin at Ser63 regulates its cleavage bycaspase-3."; Choi E.K., Miller J.S., Zaidi N.F., Salih E., Buxbaum J.D., Wasco W.; Mol. Cell. Neurosci. 23:495-506(2003). Cited for: PHOSPHORYLATION AT SER-63.	12837631 [Abstract]